HYB (Best Service and Product - International Shipping)

[carbon adams]

Yeah, why would you want a bile acid in your digestive tract? Makes much more sense to put it in your skin.

Tudca can be injected or taken orally

What is the point you are making here pal ?

 

[MyNameIsJeff]

Tudca can be injected or taken orally

What is the point you are making here pal ?

From a pharmacological perspective, administering ursodeoxycholic acid (UDCA) or tauroursodeoxycholic acid (TUDCA) via subcutaneous injection would not be advisable or effective. Here's why:

1. Mechanism of Action and Site of Activity:
   
   • UDCA and TUDCA are bile acids that exert their therapeutic effects primarily within the hepatobiliary system and gastrointestinal tract.
   • They work by modifying bile composition, promoting bile flow, and protecting liver cells from toxic bile acids.
2. Pharmacokinetics:
   
   • When administered orally, UDCA and TUDCA are absorbed in the small intestine, taken up by hepatocytes in the liver, conjugated (if not already), and excreted into the bile.
   • They undergo enterohepatic circulation, meaning they are secreted into the bile, reach the intestine, and are reabsorbed back into the bloodstream, which prolongs their presence in the body and enhances their therapeutic effect.
3. Ineffectiveness of Subcutaneous Route:
   
   • Subcutaneous injection bypasses the gastrointestinal tract, disrupting the normal absorption and enterohepatic circulation of these bile acids.
   • Without entering the digestive system, they cannot effectively reach the bile ducts or influence bile composition.
   • Additionally, the liver's uptake mechanisms for these substances are optimized for compounds arriving via the portal vein from the gut, not the systemic circulation.
4. Potential Adverse Effects:
   
   • Injecting bile acids subcutaneously could cause local irritation or inflammation, as these acids may be irritating to tissues outside the gastrointestinal tract.
   • There's also a risk of systemic side effects due to altered pharmacodynamics when bypassing the natural metabolic pathways.
5. Lack of Clinical Evidence:
   
   • As of my knowledge cutoff in October 2023, there is no clinical evidence or approved formulations supporting the subcutaneous administration of UDCA or TUDCA.
   • Standard practice relies on oral administration, which has been proven effective and safe for patients.
6. Alternative Routes in Special Cases:
   
   • In patients who cannot take oral medications (e.g., due to severe malabsorption or gastrointestinal surgery), alternative treatments are usually considered rather than changing the administration route of bile acids.
   • In such cases, other medications or therapeutic interventions are typically preferred.

Conclusion:

Administering UDCA or TUDCA via subcutaneous injection does not align with their pharmacological properties and therapeutic mechanisms. The oral route remains the most effective and appropriate method for delivering these medications to achieve their intended effects within the hepatobiliary system.

 

[carbon adams]

From a pharmacological perspective, administering ursodeoxycholic acid (UDCA) or tauroursodeoxycholic acid (TUDCA) via subcutaneous injection would not be advisable or effective. Here's why:

1. Mechanism of Action and Site of Activity:
   • UDCA and TUDCA are bile acids that exert their therapeutic effects primarily within the hepatobiliary system and gastrointestinal tract.
   • They work by modifying bile composition, promoting bile flow, and protecting liver cells from toxic bile acids.
2. Pharmacokinetics:
   • When administered orally, UDCA and TUDCA are absorbed in the small intestine, taken up by hepatocytes in the liver, conjugated (if not already), and excreted into the bile.
   • They undergo enterohepatic circulation, meaning they are secreted into the bile, reach the intestine, and are reabsorbed back into the bloodstream, which prolongs their presence in the body and enhances their therapeutic effect.
3. Ineffectiveness of Subcutaneous Route:
   • Subcutaneous injection bypasses the gastrointestinal tract, disrupting the normal absorption and enterohepatic circulation of these bile acids.
   • Without entering the digestive system, they cannot effectively reach the bile ducts or influence bile composition.
   • Additionally, the liver's uptake mechanisms for these substances are optimized for compounds arriving via the portal vein from the gut, not the systemic circulation.
4. Potential Adverse Effects:
   • Injecting bile acids subcutaneously could cause local irritation or inflammation, as these acids may be irritating to tissues outside the gastrointestinal tract.
   • There's also a risk of systemic side effects due to altered pharmacodynamics when bypassing the natural metabolic pathways.
5. Lack of Clinical Evidence:
   • As of my knowledge cutoff in October 2023, there is no clinical evidence or approved formulations supporting the subcutaneous administration of UDCA or TUDCA.
   • Standard practice relies on oral administration, which has been proven effective and safe for patients.
6. Alternative Routes in Special Cases:
   • In patients who cannot take oral medications (e.g., due to severe malabsorption or gastrointestinal surgery), alternative treatments are usually considered rather than changing the administration route of bile acids.
   • In such cases, other medications or therapeutic interventions are typically preferred.

Conclusion:

Administering UDCA or TUDCA via subcutaneous injection does not align with their pharmacological properties and therapeutic mechanisms. The oral route remains the most effective and appropriate method for delivering these medications to achieve their intended effects within the hepatobiliary system.

Where’s that info from spanky ?

Link it

 

[Yura(HYB)]

Fucking hell you should teach the other sources how to do orals.

Btw have you started the production of this tudca pills? When in another thread I suggested it many ppl were agreeing that it's something we all would buy

Yes, I am planning to announce this news! We just made 100 bottles of TUDCA 250mg x 50 capsules to check whether customers welcome this product! Because the quantity is relatively small, the cost will be slightly higher. The tentative price is: 1bottle (TUDCA 200mg x 50) 13usd
I am not sure if the price is expensive! Can you guys give me suggestions?

 

[dontletheoldmanin]

Thread 'HYB Product Janoshik test result'

Sep 13, 2024

tirzepatide 30mg:

Chromate | Analytical Services

We are committed to providing affordable analytical services for dietary supplements — protecting the health & fitness community and keeping manufacturers honest.

chromate.org

tirzepatide 20mg

Janoshik Analytical

anavar25mg

Janoshik Analytical

dbol 10mg

Janoshik Analytical

Deca 300mg

Janoshik Analytical

Test Base 100mg

Janoshik Analytical

TE250mg...

• Yura(HYB)
• Replies: 34
• Forum: Analytical Lab Testing

• 

Very cheap indeed, can anyone vouche for them or used the items?

 

[carbon adams]

The tentative price is: 1bottle (TUDCA 200mg x 50) 13usd
I am not sure if the price is expensive! Can you guys give me suggestions?

thats booty bro.

No bueno

 

[MyNameIsJeff]

Where’s that info from spanky ?

Link it

low IQ boomer

 

[carbon adams]

low IQ boomer

Sheesh that was a really mean insult. I’m upset.

 

[Sampei]

Yes, I am planning to announce this news! We just made 100 bottles of TUDCA 250mg x 50 capsules to check whether customers welcome this product! Because the quantity is relatively small, the cost will be slightly higher. The tentative price is: 1bottle (TUDCA 200mg x 50) 13usd
I am not sure if the price is expensive! Can you guys give me suggestions?
[/K]

Price is not very cheap neither expensive, let's say that as it's coming from china and not a certified supplements company I would expect a lower price.

Now I don't know the cost of production but If I was you I would sell this first batch without thinking of profit but just to gather interest in the product and just to repay yourself or the basic cost of making the batch. Next batch make a bigger one (you will have higher margin) and keep a competitive price, enjoy profit.


Have you sent those pills to test? A nice lab test showing properly dosing will seal the deal.

 

[dontletheoldmanin]

any plans to ever carry IGF-DES?

They have it.

 

[dontletheoldmanin]

Great product line up , but I'm not finding much about how geniune the stuff is.
Any feed back?

 

[17SS]

Yes, I am planning to announce this news! We just made 100 bottles of TUDCA 250mg x 50 capsules to check whether customers welcome this product! Because the quantity is relatively small, the cost will be slightly higher. The tentative price is: 1bottle (TUDCA 200mg x 50) 13usd
I am not sure if the price is expensive! Can you guys give me suggestions?

Available in the US just to give you an idea.

 

[bjjgear]

Yes, I am planning to announce this news! We just made 100 bottles of TUDCA 250mg x 50 capsules to check whether customers welcome this product! Because the quantity is relatively small, the cost will be slightly higher. The tentative price is: 1bottle (TUDCA 200mg x 50) 13usd
I am not sure if the price is expensive! Can you guys give me suggestions?

Go 500mg x 100 for $10

 

[Yura(HYB)]

I need to rethink my pricing

 

[Sampei]

Go 500mg x 100 for $10

No he should stay at 250mg, 500mg is too much for ppl that wants to take it yearly even when not doing orals.

He should do 250mgx100 for 6-7$ dollars.
That would be a great price.


This batch of 250mgx50 should be sold for far less than 13$ that's for sure.

 

[Sampei]

I need to rethink my pricing

You need to think of this batch as a promo to gather interest and then just have a bigger batch priced well.

 

[Megachocotone]

I need to rethink my pricing

I wouldn’t mind a higher dose, but maybe alternatively this can be sold in larger quantities or multiple bottles made into a better deal. I think most wouldn’t mind getting a lot more quantity if the price is low.

 

[narta]

I would go for something like $8-$9 for 250mg*100. If it cost higher, raw powder into capsules is easy to make for 1/3rd the cost so it wont be worth it to get it ready made.

And opt for $7 for a 10 bottle deal

 

[Sampei]

I would go for something like $8-$9 for 250mg*100. If it cost higher, raw powder into capsules is easy to make for 1/3rd the cost so it wont be worth it to get it ready made.

And opt for $7 for a 10 bottle deal

That's very well said Mr Narta

 

[max187]

I would go for something like $8-$9 for 250mg*100. If it cost higher, raw powder into capsules is easy to make for 1/3rd the cost so it wont be worth it to get it ready made.

And opt for $7 for a 10 bottle deal

Agreed