Intramuscular Glutathione Homebrew

[Croce73]

Wow. This is such a valuable resource. Thanks for sharing. I just need to find a good source for Sodium Hydroxide in my country and when I do I will brew my perfect batch.

I may even go with 6.0 pH since this paper shows that at 5 degrees C and 6.4 pH it stays stable for at least 3 months.
US6835811B1 - Extended storage of reduced glutathione solutions - Google Patents

Yes I wish I could help you with source. Here in the US it’s as easy as ordering from Amazon.

 

[Luka.Halotestin]

So I did this process and this time I managed to dissolve it completely.

1) I added 6 grams of Glutathione Reduced powder into my beaker.
2) Added Bacteriostatic Water while mixing on a magnetic stirrer until it reached 30 ml.
3) Got a milky subrance.
4) Checked the pH and it was around 2.3.
5) Started adding NaOH slowly while checking the pH and mixing.
6) Solution started clearing up completely at about 4.0 pH.
7) Added NaOH until pH was 5.0.
8) Filtered everything in 3 vials of 10 ml through a 0.22 nylon66 filter.
9) The end result is a crystal clear solution at 200 mg/ml that holds perfectly at low temperatures (I keep it in the fridge).

My only concern is- I tried it 2 times. First time 200 mg and it was ok. Second time I did 360 mg and my nose and ears feel a bit clogged after that. Does anyone else have the same experience?

 

[Croce73]

So I did this process and this time I managed to dissolve it completely.

1) I added 6 grams of Glutathione Reduced powder into my beaker.
2) Added Bacteriostatic Water while mixing on a magnetic stirrer until it reached 30 ml.
3) Got a milky subrance.
4) Checked the pH and it was around 2.3.
5) Started adding NaOH slowly while checking the pH and mixing.
6) Solution started clearing up completely at about 4.0 pH.
7) Added NaOH until pH was 5.0.
8) Filtered everything in 3 vials of 10 ml through a 0.22 nylon66 filter.
9) The end result is a crystal clear solution at 200 mg/ml that holds perfectly at low temperatures (I keep it in the fridge).

My only concern is- I tried it 2 times. First time 200 mg and it was ok. Second time I did 360 mg and my nose and ears feel a bit clogged after that. Does anyone else have the same experience?

Luka,

Sounds good bro. As you can see- pretty acidic substance. What I know is that most (maybe all) compounding pharmacies tap out at 200mg/ml. So perhaps the 360 mg, even though it dissolved, is giving you unwanted side effects - hence why the pharmacies don't go that high....

Any PIP, any other sides? I noticed tiredness after doing 200mg.

And what concentration NaOH did you use? I used 10%.

 

[Luka.Halotestin]

Luka,

Sounds good bro. As you can see- pretty acidic substance. What I know is that most (maybe all) compounding pharmacies tap out at 200mg/ml. So perhaps the 360 mg, even though it dissolved, is giving you unwanted side effects - hence why the pharmacies don't go that high....

Any PIP, any other sides? I noticed tiredness after doing 200mg.

And what concentration NaOH did you use? I used 10%.

No no. I went 1.8 ml of 200 mg/ml so total was 360 mg.
I used raw NaOH. PIP was considerable but nothing unbearable.

 

[edjohn88]

If anyone is still here... could you use this stuff? Inositol has its own benefits...

Glutathione Supplement, Pure Glutathione Reduced Powder with Inositol​

Amazon.com

 

[cosmoxero]

I know it's an old thread but can this recipe be injected intravenously?

 

[Tgf]

I know it's an old thread but can this recipe be injected intravenously?

You'll want to use a buffer it and use it as a drip alongside something like Meyers solution. Something like 100mg over 30+mins should be adequate dilution.

If you try to IV 1mL of say 100mg/mL, unbuffered, you're going to be in for a wild ride that's probably doing more harm than good.

In otherwords, there's zero reason to do this because the bioavailability of IM is that of IV unless you just like practicing being a junkie.

Or you want to hero dose through an IV bag and turn into pink Sammy Sosa.

 

[Tkjo]

For US based folks, where are you ordering your sterile NaOH? I found this at Teknova, but it’s 5M and a little stronger than what was mentioned here(10% NaOH solution). They also sell 1M but I’m not sure if adding that would raise the pH quick enough considering it’s also adding more water.

 

[mochul]

For US based folks, where are you ordering your sterile NaOH? I found this at Teknova, but it’s 5M and a little stronger than what was mentioned here(10% NaOH solution). They also sell 1M but I’m not sure if adding that would raise the pH quick enough considering it’s also adding more water.

What do you mean by quick? You just need to add less water since you will be using more 1M naoh to raise the ph. Is your glutathione ready to inject and you just want to increase the ph?

 

[sinistral]

For US based folks, where are you ordering your sterile NaOH? I found this at Teknova, but it’s 5M and a little stronger than what was mentioned here(10% NaOH solution). They also sell 1M but I’m not sure if adding that would raise the pH quick enough considering it’s also adding more water.

I use this and make my own 10% solution and add it prior to filtering so it doesn't need to be sterile.

https://www.amazon.com/gp/product/B0875LR274

 

[Tkjo]

I use this and make my own 10% solution and add it prior to filtering so it doesn't need to be sterile.

https://www.amazon.com/gp/product/B0875LR274

That is way simpler than what I was thinking. Thank you

What do you mean by quick? You just need to add less water since you will be using more 1M naoh to raise the ph. Is your glutathione ready to inject and you just want to increase the ph?

I could’ve used a better word choice. I meant not being able to adjust the pH per drop as easily. I’m not familiar with the molar concentration scale or brewing.

Appreciate the help, as well as previous experiences and knowledge share.

 

[mochul]

That is way simpler than what I was thinking. Thank you

I could’ve used a better word choice. I meant not being able to adjust the pH per drop as easily. I’m not familiar with the molar concentration scale or brewing.

Appreciate the help, as well as previous experiences and knowledge share.

Every mol of naoh is 40 grams. 1M means one molar per liter