I started with the low dose protocol, given the potentially horrible side effects.
Titrated 10mg/day, 20 (splitdose), 30, 40, 60, 80, 90, 100, now 120mg/day at 90kg. Splitting the dose seems to be key to reducing sides. At each increase, I had some minor back/joint pain that resolved in a few days.
Now all I have at 120mg/day is chapped lips, slightly dry eyes, and "fragile" skin, all typical and easily manageable. I plan to hit 150mg/kg cumulative dose after 20 weeks treatment.
I hadn't planned on deviating from the low dose, but given the better long term outcomes, ie, no need for retreatment, associated with courses at least 5 months, and at higher cumulative doses, and the tolerable sides, I figured I may as well cover all the bases and get it over with.
I *love" how much less sebum I produce, I've never been able to avoid washing my hair once or twice a day without it becoming really greasy, and the shrunken pores have made my skin look incredible.