So these decades of evidence have to do with isotret in conjuction with.. whatever youre putting in your body?
Everyones iso usage on here is very much off label and in no way recommended by doctors. If youre sticking to the medical industry's opinion, you wouldn't be ordering drugs from sketch overseas parmacies.
Also Ive been scribed full 6 month courses of the stuff twice in my twenties, and it always comes back on cycle. I'll stick to the smallest dose of this powerful and side effect -ridden drug while on.
I always debate whether it's worth tearing down "feels" arguments since it never gets anywhere with a Tren jacked poster, but for the benefit of everyone else I will.
Those "sketch" pharmacies are usually the same sources, Sun Pharma, Intas, and the same FDA approved oil filled gel capped Accutane generics you get from your local pharmacy.
Not the dry tabs of isotretinoin you get from your drug dealer, a form that's never been approved, for good reasons.
Crying about the sides and suggesting a relapse free outcome isn't possible sounds like you're pretty bitter from an acne scarred youth, and you're belligerent enough you probobly fall into the large group who didn't comply very well with the initial prescribed treatment.
After forty fucking years we have a "little" data to work with.
The TLDR is:
~Sides are predictable, manageable, and reversible, with very rare exceptions. Not the nightmare inducing shit pussy's would have us believe from their memories as a traumatized 13 year old.
~High cumulative dose = Much lower chance of relapse.
-Lower, "standard" dose from decades ago=much higher rate of relapse.
Almost all problematic acne is rooted in shifting hormone levels. Everyone *is* different, but this, more than almost any other medical treatment happens to be better suited to dealing with an AAS induced condition, hormones fluctuating like going through puberty, than almost any other.
There aren't any doctors advising the high dose protocol we're discussing, you're right there.
Except for all these doctors.
The dosing regimen used in the present study is considerably higher than that used in previous studies of isotretinoin. At 1 year after completion of isotretinoin treatment, we found that patients receiving 220 mg/kg or more had a significantly decreased risk of relapse. Rash was the only...
pubmed.ncbi.nlm.nih.gov
www.consultant360.com
Isotretinoin prescribed at 1.5 mg/kg/day or greater for 5-6 months [cumulative total dose of 290 mg/kg] is safe and effective compared to current standard dosing practices. We propose the use of high-dose isotretinoin (>1.3 mg/kg/day) as a treatment option in severe nodulocystic acne and encourag …
pubmed.ncbi.nlm.nih.gov
I think you meant no one's advocating YOUR protocol, except for some guys at the gym.
The only point you're right about is none of this is applicable to those using extrogenous hormones to reach supraphysiological levels.....except these girls bringing their Testosterone up 15,000% from physiologic:
(where, once again it's clear large cumulative dose=much lower chance of relapse, even as they keep pinning steroids)
Among transgender and gender-diverse individuals with acne receiving masculinizing gender-affirming hormonal therapy, isotretinoin may likely improve acne symptoms.
www.dermatologyadvisor.com
