It's not that you have to use "per dose filtration" to benefit from filtering peptides. Reconstituting, pulling the whole thing into a syringe, attaching a filter, and injecting into a certified particle free vial is a huge improvement over current practice. Injecting back into the same vial is less desirable, but still a major improvement over nothing. Even just using pharma BAC or UGL BAC and the correct dilution ratio all help make the peptide safer, and likely more effective over the long term.
Like so many things there's the theoretical ideal, and a million steps short of that which are still worth doing and providing a benefit.
I like to define the theoretical "ideal", knowing what matters is what you can and are willing to actually do. Something determined by each individual.
I certainly make compromises as to how far I'm willing to go.
I try to translate known risks (often impossible to quantify with UGL compounds but real nonetheless) into "actionable" steps to reduce them, (
@Dirthand).
Never let the perfect be the enemy of the good, as they say.
Protein immunogenicity is intensively researched by academics, biopharmaceutical companies, and authorities as it can compromise the safety and efficacy of a biopharmaceutical drug. So far, the exact protein aggregate properties inducing immune responses are not known. Possible protein-related...
pubmed.ncbi.nlm.nih.gov
