low COMT function

[Amgiji]

I have low comt (Catechol-O-methyltransferase) function

is there any way (food, supplements, drugs prescription or other wise)

to increase my clearance rate of catechol / catecholamines?

I can only find comt inhibiters.

 

[AlexDavis43]

I have low comt (Catechol-O-methyltransferase) function

is there any way (food, supplements, drugs prescription or other wise)

to increase my clearance rate of catechol / catecholamines?

I can only find comt inhibiters.

Depending on what service you had that assessed, they have a recommendation section. Probably have to pay for it.

There are also some other people/services who will analyze your results and provide recs, but you have to pay for them too. LifeDNA, MasterPass, and a few others, etc.

 

[Kralteramon]

I have the same mutation "worrier". Also wondering the same. There barely is any information out there. However I did find that homovanilic acid plays a crucial role in the breakdown of dopamine and worrier met/met type carriers have less of it. I'm currently experimenting with low dose Nandrolone (150mg wk) as Nand increases homovanilic acid and enhances the dopamine breakdown mechanism resulting in more motivation and cognitive enhancement. However chronic and or high dose nand actually downregulates dopamine receptors and is directly toxic to the dopamine system so it's not just a boon. I'm not advocating for using nand at all but it might help as I'm also trying to find out how to deal with the downsides of the SNP. It truly has a lot of downsides.. upside is good memory and recall. There are a few more but for me it's mostly downsides.. ADHD symptoms, anxiety etc. I believe it all comes from the cathecholamine alterations that this gene emposes. Would love to have a bigger discussion around this topic!

 

[Kralteramon]

I wanted to add. COMT uses methylation to break down dopamine into homovanilic acid so anything that supports methylation or acts as a methyl donar can help too. I'm using TMG for this.