Making gummies for orals: How long do they last?

[ThiccManJack]

Planning on making gummies for orals, how long do they last? Like will the drug "go bad" so to speak or degrade in quality after a certain amount of time because it's sitting in a not-perfectly-dry environment? Decided to switch from capping to gummies because it's way faster to get even concentrations. I hate the process of geometric dilution and I'm only making personal batches so I'm not planning on investing in any fancy machines.

 

[baxter0312]

You still have to levigate the compound to form a uniform "base". I hope you're not just throwing everything in a bowl like your making pancakes

 

[ThiccManJack]

You still have to levigate the compound to form a uniform "base". I hope you're not just throwing everything in a bowl like your making pancakes

Yeah I know, it's way easier though to ground small dosages. Way less powder I have to ground to make 100 10mg gummies than 100 10mg capsules with about 200mg of sugar/capsule lol.

 

[baxter0312]

not sure what you're making , are you talking about fast dissolving tabs?

you're diluting the compound with a sweetener which takes the place of the geometric dilution, to do that you need to grind everything so its uniform or else they will settle out from each other. you then blend with the carrier

 

[AlexDavis43]

Testing testing testing

I was surprised by seeing highly differential rates of melatonin deterioration in various melatonin gummy preparations (unpublished).

Only way to know is to have them tested.

 

[Cohiba]

Anavar gummies? Sign me up

 

[ThiccManJack]

not sure what you're making , are you talking about fast dissolving tabs?

you're diluting the compound with a sweetener which takes the place of the geometric dilution, to do that you need to grind everything so its uniform or else they will settle out from each other. you then blend with the carrier

Gummy bear dbol, adrol, tadalafil, cardarine, etc. lol. For swallowing. But I saw a formulation from some compounding pharmacy publication that gave a formula with cyclodextrin for sublingual. I'll probably use cyclodextrin anyways. I wouldn't need to grind anything other than the active ingredient because it'll be melted into a liquid before you pour it over the mould and it's cooled.

 

[ThiccManJack]

Testing testing testing

I was surprised by seeing highly differential rates of melatonin deterioration in various melatonin gummy preparations (unpublished).

Only way to know is to have them tested.

Can you give away the range and average of what you saw? I'm not a source so I'm trying my best not to spend insane amounts of money on testing.

 

[Spaceman Spiff]

Can you give away the range and average of what you saw? I'm not a source so I'm trying my best not to spend insane amounts of money on testing.

Don't make gummies. It sounds like you dont even have enough money to ensure safety not if sounds like you have much experience making orals...

 

[narta]

But I saw a formulation from some compounding pharmacy publication that gave a formula with cyclodextrin for sublingual.

Can you provide a link?

 

[ThiccManJack]

Don't make gummies. It sounds like you dont even have enough money to ensure safety

What do you mean ensure safety? Like making sure that it's evenly dispersed? If you're referring to that, I imagine a hotplate and magnetic stirrer sitting however long I want it to stir is gonna be way more accurately dosed than manually grinding powder. That would be like saying I don't have enough money to ensure my brews are evenly mixed just because I don't send a batch to jano every time I brew. I'm not sure if everyone on this thread is confused on what I mean by gummies but I mean making them like this. Not with all the sugar, but the general principle. And instead of hand stirring just making it in a beaker with a magnetic hot plate and stirrer.

 

[AlexDavis43]

I'm not a source so I'm trying my best not to spend insane amounts of money on testing.

Maybe your source or someone else can help off-set the cost of testing.

Melatonin is a fat soluble hormone with some some structural similarities to other hormones but I wouldn't apply this across the board.

Can you give away the range and average of what you saw?

No, but what is it worth to you? Do you have pre-set limits for cost? (eg, X grams of Y purity for Z dollars)

I doubt you'd need to spend "insane amounts of money on testing" to get a good ballpark estimate

 

[baxter0312]

What do you mean ensure safety? Like making sure that it's evenly dispersed? If you're referring to that, I imagine a hotplate and magnetic stirrer sitting however long I want it to stir is gonna be way more accurately dosed than manually grinding powder. That would be like saying I don't have enough money to ensure my brews are evenly mixed just because I don't send a batch to jano every time I brew. I'm not sure if everyone on this thread is confused on what I mean by gummies but I mean making them like this. Not with all the sugar, but the general principle. And instead of hand stirring just making it in a beaker with a magnetic hot plate and stirrer.

I already answered you in the other thread you made as well. I don’t think you’re following the recipes correctly

 

[ThiccManJack]

Can you provide a link?

Searching it up again I just see a bunch of studies some-what related to it but not what I found.
Gelatin-based hydrogels with β-cyclodextrin as a dual functional component for enhanced drug loading and controlled release

Fast-dissolving sublingual solid dispersion and cyclodextrin complex increase the absorption of perphenazine in rabbits

Cyclodextrin-Containing Hydrogels: A Review of Preparation Method, Drug Delivery, and Degradation Behavior

Pharmaceutical applications of cyclodextrins and their derivatives - Journal of Inclusion Phenomena and Macrocyclic Chemistry

I was looking a lot on Uspharmacist so perhaps it was there? But it doesn't look like I have it bookmarked. Or perhaps I dreamt it and I'm wrong.

 

[Spaceman Spiff]

What do you mean ensure safety? Like making sure that it's evenly dispersed? If you're referring to that, I imagine a hotplate and magnetic stirrer sitting however long I want it to stir is gonna be way more accurately dosed than manually grinding powder. That would be like saying I don't have enough money to ensure my brews are evenly mixed just because I don't send a batch to jano every time I brew. I'm not sure if everyone on this thread is confused on what I mean by gummies but I mean making them like this. Not with all the sugar, but the general principle. And instead of hand stirring just making it in a beaker with a magnetic hot plate and stirrer.

It doesn't dissolve like a solution in that type of liquid. It won't evenly disperse.

If it did, then we wouldn't be making suspensions, if would all be solution.

 

[ThiccManJack]

I already answered you in the other thread you made as well. I don’t think you’re following the recipes correctly

You replied with a recipe from Uspharmacist about tablets, I am talking about gummies. Like gummy bears. Like haribo. Like the candy. I'm not trying to follow that recipe for tablets. Or are you referring to something else?

 

[ThiccManJack]

It doesn't dissolve like a solution in that type of liquid. It won't evenly disperse.

If it did, then we wouldn't be making suspensions, if would all be solution.

Narta posted on a separate thread I made asking about sublingual tablets, he said he made sublingual cialis gummies using cyclodextrin. I asked him for the recipe and he said it's proprietary. Since then I'd been researching on how to make such a preparation. If you're correct, this is all in vain. I just assumed what Narta said was legit lol.

 

[baxter0312]

You replied with a recipe from Uspharmacist about tablets, I am talking about gummies. Like gummy bears. Like haribo. Like the candy. I'm not trying to follow that recipe for tablets. Or are you referring to something else?

You aren’t getting the core principle here. It doesn’t matter what you’re making you do the same thing first. Take these examples:

Bupropion 30 mg/mL Oral Suspension

www.uspharmacist.com

“Combine the bupropion HCl with a small volume of propylene glycol (PG) to achieve a homogeneous paste.”

Fentanyl 10 mcg Rapidly Dissolving Tablets

www.uspharmacist.com

“Blend the fentanyl citrate, mannitol, lactose, and dry flavor until fine and uniformly mixed. ”

You are trying to take shortcuts and not doing that.

 

[Spaceman Spiff]

Narta posted on a separate thread I made asking about sublingual tablets, he said he made sublingual cialis gummies using cyclodextrin. I asked him for the recipe and he said it's proprietary. Since then I'd been researching on how to make such a preparation. If you're correct, this is all in vain. I just assumed what Narta said was legit lol.

I just wanna see testing from anyone who makes their own unique preparations.

 

[baxter0312]

Another:

Citalopram 20 mg Troches

www.uspharmacist.com

Method of Preparation: Calculate the required quantity of each ingredient for the total amount to be prepared. Accurately weigh and/or measure each ingredient. Citalopram hydrobromide (HBr) 1.25 mg is equivalent to citalopram 1 mg. Melt the polyethylene glycol (PEG) troche base at 50°C to 55°C until just melted. Separately, mix the citalopram HBr powder with the glycerin to form a smooth paste. Add the mixture to the melted PEG troche base while mixing constantly. Cool the mixture slightly and pour it into molds. Package and label.