MALDI-TOF-MS/HPLC-UV-VIS rHGH results

from what little I know and read, one of the things it could be is leftover proteins that can cause antibody reactions which can make you allergic to your own hgh. it's pretty scary stuff

Scary stuff? Where is the science? Show me the studies or what you read.
 
Show me the science. These so called impurities are simply part of the purification process. The same impurities are in pharm grade just in smaller amount. As I pointed out in the thread, someone taking 20iu of 98% pure Serostim is getting the same impurities as someone taking 4iu 90% pure generic GH. If those impurities taken at those dosages were dangerous then the product would never have reached FDA approval considering AIDS patients are told to take 1 vial a day of Serostim.

So talk about broscience, where is the real science showing 88% purity Rips causes autoimmune response?
you show me the science where it's been proven that injecting impure hgh is ok. one single link would be fine. how about all the reports that peoples side effects disappeared when switching to pharma. or the fact that impure hgh can cause an autoimmune response. not to mention that serostim has underwent extensive testing by the fda and has been approved for human use. I must have missed the part where the chinese generics received fda approval. I don't mind having scientific debates, but you're making stuff up now, and saying injecting lower purity hgh is ok because you think it is, is wrong
 
Scary stuff? Where is the science? Show me the studies or what you read.
this guys seems pretty knowledgeable, hanging your hat on an argument that there is no problem with lower purity hgh is just wrong

http://drcranton.com/hrt/cautions_generic_HGH.htm
 
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Dimmer and related substances of higher molecular mass: rhGh aggregates that coexist with normal rhGh. They don't have biological activity and cause antibody of rhGh. The antibody combines to rhGh molecule. The antibody prevents the rhGh from combining to it's receptor to stimulate growth, cause the biological activity of rhGh to decrease .
Standard:
According to European Pharmacopoeia 5.0, the content of dimer and related substances of higher molecular mass of Somatropin should be no more than 4.0%

The Generic tested was underdosed and 18% "impurities"

This would not be prescribed for Therapeutic means

18.8% is actually not bad compared to some Generic test results I've seen

I've seen some Generics test very "pure"

But, you gotta test it and not over analyze a $45 Lab Corp GH Serum score

So what GH Serum "score" would be equivalent to the "Pharma" standards ?
 
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Dimmer and related substances of higher molecular mass: rhGh aggregates that coexist with normal rhGh. They don't have biological activity and cause antibody of rhGh. The antibody combines to rhGh molecule. The antibody prevents the rhGh from combining to it's receptor to stimulate growth, cause the biological activity of rhGh to decrease .
Standard:
According to European Pharmacopoeia 5.0, the content of dimer and related substances of higher molecular mass of Somatropin should be no more than 4.0%

The Generic tested was underdosed and 18% "impurities"

This would not be prescribed for Therapeutic means

18.8% is actually not bad compared to some Generic test results I've seen

I've seen some Generics test very "pure"

But, you gotta test it and not over analyze a $45 Lab Corp GH Serum score

So what GH Serum "score" would be equivalent to the "Pharma" standards ?
I guess what confuses me the most is they've had years to get hplc testing on gear (that even the sponsors volunteered to pay for the tests), to run igf tests and logs of side effects, yet they keep hanging their hat on serum tests, and yell yippee when they come out high. it seems to me that if they want their bros to get the best, safest hgh, that they would cover all the bases.
 
you show me the science where it's been proven that injecting impure hgh is ok. one single link would be fine. how about all the reports that peoples side effects disappeared when switching to pharma. or the fact that impure hgh can cause an autoimmune response. not to mention that serostim has underwent extensive testing by the fda and has been approved for human use. I must have missed the part where the chinese generics received fda approval. I don't mind having scientific debates, but you're making stuff up now, and saying injecting lower purity hgh is ok because you think it is, is wrong

You are misinterpreting what I am saying. What I am saying is that I have no idea what the impurities are in terms of their actual content and their effect on the body. So how can you say taking 1 vial of Serostim per day at with 2% impurities is safe but taking 4iu of generic GH with 10 or 12% impurities is not safe. Where is the cutoff? At what point or percentage do the impurities become a factor? We have absolutely no idea. So all that I am saying is that from a mathematical point of view, someone injecting 1 vial of Serostim per day is probably injecting the same amount of impurities in their body as someone injecting 4iu of 90% pure GH. So if the same amount of impurities are being injected, I would expect the same reactions. Thats all I am saying.
 
You are misinterpreting what I am saying. What I am saying is that I have no idea what the impurities are in terms of their actual content and their effect on the body. So how can you say taking 1 vial of Serostim per day at with 2% impurities is safe but taking 4iu of generic GH with 10 or 12% impurities is not safe. Where is the cutoff? At what point or percentage do the impurities become a factor? We have absolutely no idea. So all that I am saying is that from a mathematical point of view, someone injecting 1 vial of Serostim per day is probably injecting the same amount of impurities in their body as someone injecting 4iu of 90% pure GH. So if the same amount of impurities are being injected, I would expect the same reactions. Thats all I am saying.
muscle, one thing I can I am dead right about, is that you can't use mathematical equations when it comes to the human body and safety of a substance that you are injecting. by the way, I am an electrical engineer and an expert in statistics, so I'll go toe to toe with math on anyone
 
muscle, one thing I can I am dead right about, is that you can't use mathematical equations when it comes to the human body and safety of a substance that you are injecting. by the way, I am an electrical engineer and an expert in statistics, so I'll go toe to toe with math on anyone

But what is he saying?

90%
80%
76.677776%

How does he even know? From those GH Serums?

The Source Told em?

Oh that's right.....they haven't actually tested the products themselves....so he can't possibly know
 
Guys, I'll be back in a few. I am just going out back to grab some 100's off my money tree and then go next door to the lab and drop off some samples. I should have the results back by this afternoon.
 
i don't think he was out of line, and i thought his arguments were presented calmly without attacking anyone. And I don't think he had a problem catching any heat, that thread shut him down, and lost a tremendous amount of credibility as a result

Let me repeat something I mentioned before. You are coming into 1 point of a huge/long conversation without prior knowledge of the rest of the conversation or the history of the participants. You really need to read the whole thread from page 1 rather than skimming it to fully understand things. Both Karl and TP are very well liked and thought to have quality products by most of the participants in that thread. In fact, I have taken on the entire board here at Meso a year or two ago when I thought that Karl was being treated unfairly; just ask CBS. It was a huge, long, drawn out affair; but I stood up for what I feel is right. So for you to say that the thread lacks credibility, clearly demonstrates a lack of knowledge on your part of what has all transpired.
 
Relax!

I was kiddn to my brutha :)

Trust me, we are doing the lab testing over at PM. The only holdup is that Matthias is out of the office until the 5th and Dr. A and Julian are not being very responsive. Hopefully Matthias has a higher level of communication ro we will have to find a different lab.
 
By the way, TP destroyed himself in my eyes with his arguing yesterday, he looked like an idiot. I thought Karl made a pretty good case and attacked no one. And to remind everyone, I could give a rats ass about karl, the only thing that thread is doing for me is telling me to stick with pharma.

See, here is where you are missing the history. Karl DID attack TP and has done so on several prior occasions. TP is very calm, laid back, and a man of few words on most occasions. He tries to stay out of all the drama and shit. I applaud him for saying what he did and wish he would speak more often.
 
Trust me, we are doing the lab testing over at PM. The only holdup is that Matthias is out of the office until the 5th and Dr. A and Julian are not being very responsive. Hopefully Matthias has a higher level of communication ro we will have to find a different lab.

Welcome to my world. I've been dealing with them since 2014. Its not as easy as you'd think. It takes time. I've got samples out now....waiting a month I think.

But......testing is the way to go if the main subject is learning

At the end of the day....we all just want a good product...especially one that gets pinned ED for months
 
You are misinterpreting what I am saying. What I am saying is that I have no idea what the impurities are in terms of their actual content and their effect on the body. So how can you say taking 1 vial of Serostim per day at with 2% impurities is safe but taking 4iu of generic GH with 10 or 12% impurities is not safe. Where is the cutoff? At what point or percentage do the impurities become a factor? We have absolutely no idea. So all that I am saying is that from a mathematical point of view, someone injecting 1 vial of Serostim per day is probably injecting the same amount of impurities in their body as someone injecting 4iu of 90% pure GH. So if the same amount of impurities are being injected, I would expect the same reactions. Thats all I am saying.

According to European Pharmacopoeia 5.0, the content of dimer and related substances of higher molecular mass of Somatropin should be no more than 4.0%

I had an Authentic GenLei Jintropin tested for % purity. It's was <2.0% (apprx 1.8%)

Generic tested 18.8%

The higher "impurities" is what gets mentioned about (Tolerance/Protein Immunogenicity - diminishing IGF1)
 
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According to European Pharmacopoeia 5.0, the content of dimer and related substances of higher molecular mass of Somatropin should be no more than 4.0%

I had an Authentic GenLei Jintropin tested for % purity. It's was <2.0% (apprx 1.8%)

Generic tested 18.8%

Yes, that is the general standard, but what is its scientific basis? For example, there is also a standard for expiration dates of drugs. But that doesn't mean that the drug is not safe or is degraded after the expiration date.
 
Yes, that is the general standard, but what is its scientific basis? For example, there is also a standard for expiration dates of drugs. But that doesn't mean that the drug is not safe or is degraded after the expiration date.

European Pharmacopoeia 5.0 (page 2464)

Maybe try there?

Pfizer vs Omnitrope
Product Tested/Bioassays

Molecular variants have the potential to induce an immune response

A Generic source mentioned IGF1 was diminishing after a couple months of use of a generic product . That would be a sign of a product with high % impurities
 
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European Pharmacopoeia 5.0 (page 2464)

Maybe try there?

Pfizer vs Omnitrope
Product Tested/Bioassays

Molecular variants have the potential to induce an immune response

Here we go again. How about posting the links? You can make any claim you want, and you can claim that its backed up in any piece of literature that you want. But its meaningless if you don't post the actual literature. I apologize for not having my European Pharmacopoeia 5.0 handy to turn to page 2464; so perhaps you could copy and paste or post a link to the verbiage on that page.
 
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