You guys always ask "where's the science"? When we post the science (BioSimilar is not a Generic) there's no discussion about Protein Immunogenicity with (GENERIC GH) Elevated Impurities causing Low IGF1 results. Why is that? That's why I don't want to even bother sharing some of my Lab Test, Blood Work results, etc. You guys fight everything tooth n nail
Why is that?!
Now BUCK is posting about eRoids being a scam or whatever.....but he sure doesn't mind ripping off my SIMEC GH Results and posting them on PM.
It's weird how BUCK does his GH Serum testing down to the minutes/seconds yet this test he says it was an hour and 1/2. Why is that? It's like you guys don't want to accept that GH Testing Protocol is BroScience. My posting about BioSimilars show how the product must be tested. You can't determine if these Color Tops are "quality" by Blood Serums....PERIOD
YOU GUYS ARE REALLY NICE VIA PM WHEN YOU WANT INFO ABOUT LAB TESTING
I've just got to shake my head in disappointment
I'm about learning.....I'm not pushing any Color Tops
pharmacokinetics
[fahr″mah-ko-kĭ-net´iks]
the study of the movement of drugs in the body, includingthe processes of absorption, distribution, localization intissues, biotransformation, and excretion. adj., adjpharmacokinet´ic.
In
statistics, the
standard deviation (
SD, also represented by the Greek letter sigma
σ or
s) is a measure that is used to quantify the amount of variation or
dispersion of a set of data values.
[1] A standard deviation close to 0 indicates that the data points tend to be very close to the
mean (also called the expected value) of the set, while a high standard deviation indicates that the data points are spread out over a wider range of values.
View attachment 34330
The Cmax is often measured in an effort to show
bioequivalence between a generic and innovator drug product.
[4] According to FDA, drug quality BA (
bioavailability) and BE (
bioequivalence) rely on pharmacokinetic measures such as
AUC and Cmax that are reflective of systemic exposure.
[5]
In
pharmacology (and more specifically
pharmacokinetics),
absorption is the movement of a drug into the bloodstream.
In other situations, such as
intravenous therapy,
intramuscular injection,
enteral nutrition and others, absorption is even more straightforward and there is less variability in absorption and
bioavailability is often near 100%.
Bioavailability: It describes the amount of drug that is available to the body to produce a therapeutic effect.
In
medicine, the
clearance is a
pharmacokinetic measurement of the volume of plasma that is completely cleared off of a substance per unit time. The usual units are ml/min
[1]
PHARMACOKINETICS: Elimination (p.1)
Concept of (plasma) “half-life”
A time measurement, which starts when the drug reaches equilibrium
(“equilibrium” = “fully absorbed” = when equal amounts of drug are in circulation and at point of administration)
Drug metabolism/biotransformation
This mainly occurs in the liver, via liver enzymes
But it can also occur in the blood plasma or at various other places
(stomach, intestines, lungs, skin, or kidneys) directly by various
enzymes at those locations
In any case, these metabolites are then excreted/eliminated (more
easily than would the parent molecule have been) metabolites are often smaller in size, ionized
Pharmacokinetics24,25,26,27,28,29,30,31,32,33
Growth hormone is administered by IM or SC injection. Peak plasma concentrations of somatropin are reached two to six hours following administration. Approximately 20 percent of the circulating somatropin is bound to growth hormone-binding protein (IGFBP3). The plasma elimination half-life is approximately 20 to 30 minutes. Clearance of somatropin is via kidney and liver, the half-life of clearance is approximately 2 to 3 hours, the un-metabolized growth hormone excreted in urea is almost immeasurable. The absorption (CMax) of somatropin occurs 3 to 5 hours after injection metabolizing into a metabolite called insulin-like growth factor type 1 (IGF-1). Because of continued release of somatropin from the injection site, serum concentrations decline with a half-life of about three to five hours. Peak plasma concentrations of IGF-1 occur about 20 hours after administration of somatropin. Because of the slow induction and clearance of IGF-1, the effects of somatropin last much longer than its elimination half-life.
Pharmacokinetics of human growth hormone administered subcutaneously with two different injection systems.
Abstract
The bioavailability of recombinant human growth hormone (somatropin, CAS 12629-01-5) was compared between a transcutaneous jet injection device and subcutaneous cannula injection. Thirteen healthy male subjects received 8.64 IU somatropin once with jet and once with cannula injection in a randomized cross-over study. Baseline-corrected somatropin serum concentrations were evaluated with non-compartmental and compartmental methods. The 90% confidence intervals with two one-sided t-tests around the ratios of injection devices were 91-120% for maximum concentration, 94-110% for area-under-curve until 14 h, and 92-103% for area-under-curve to infinity. Somatropin has a known metabolic half-life of ca. 20-30 min while the observed terminal half-lives were 2-4 h. Absorption and elimination rate constants were similar. Times of maximum concentrations, terminal half-lives and lag times to start of absorption appeared to be shorter and the absorption rate constant appeared to be larger for jet than for cannula injection. In conclusion, the kinetics of somatropin from subcutaneous tissue had a "flip-flop" characteristic. Bioavailability of somatropin after jet injection was equivalent to cannula injection.
IGF-1 test
The level of IGF-1 hormone and HGH in the body are tightly correlated. Injecting growth hormone will raise a person's IGF-1 levels as well. Elevated IGF-1 levels are thus a good indicator of authentic HGH. The IGF-1 test is performed by having your blood tested for IGF1 prior to injecting growth hormone. Afterwards, take 4IU of HGH and 3 hours later have the same IGF1 blood serum test repeated. If your product is real the 2nd result should show a drastic increase in serum level.
THE POINT OF THE FOLLOWING BLOOD WORK WAS TO SHOW THAT THESE GENERIC GH SOURCES WERE SPEWING BROSCIENCE ABOUT THE ELEVATION OF IGF1
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6IUS SubQ...Blood taken approx. 3HRs after Inject
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540 ng/mL after 3 SubQ injects of 6IUs
All of the blood work was done using Pharma products or "Generics" that were tested at an accredited lab first.
There's no agenda.....just showing that IGF1 DOESNT TAKE FOUR WEEKS TO ELEVATE
)
