melatonin

[CenDS]

Yes, Valerian and Melatonin work for me too. I used them pretty extensively when I was using Tren about 7 years ago on a heavy cycle and it helped a lot. Trazadone is good but it's a pharm and I feel the naturally occuring is better than Valium or a drug like Trazadone.

trazadone should never be used by men...........its major side effect is ED. It works well in women but even they report decreased orgasm........due to effect of nitric oxide release on the endothelium.

 

[BBC3]

I find that statement troubling to say the least. Trazadone is a failed SSRI gone sleep aid. The SSRI dose is 4-600mgs/day. The Sleep aid does is 50ms/night.

One of the major warnings on this drug is the increased chance of Priapsim!!! Even at small doses such as these they can occur. While the risk must always outweight. The drug is used these days primarily to get withdrawing substance abuse patients to sleep. I find it disturbing that you could post such a thing.

I have never had a fatter loafer, and ready to get hard, as when I took Trazadone.

So pull the other one. What are you saying? That the use of Cialis long term will result in ED?? Are you stating that the constant, or exagerrated expansion of blood flow to these areas is a long term deficit?? Really, I want to know.. Because I find it funny that you could make a statement like that and NOT reference the PATIENT PRESCRING INFO.... So no tricks.

You may be the best trained MONKEY I have ever seen....

trazadone should never be used by men...........its major side effect is ED. It works well in women but even they report decreased orgasm........due to effect of nitric oxide release on the endothelium.

 

[Michael Scally MD]

trazadone should never be used by men...........its major side effect is ED. It works well in women but even they report decreased orgasm........due to effect of nitric oxide release on the endothelium.

This is exactly the opposite of the published literature. Further, I found it is useful as a sleep aid due to its nonaddictive nature. In fact, one of the cited effects of Trazodone is Priapism. As it seems like you need the "Librarian's" help, I have attached articles for you to read and include the abstracts following. Why there is even a link!!! [How about that cite on DHT & ED?]


TRAZODONE HAS BEEN ASSOCIATED WITH THE OCCURRENCE OF PRIAPISM. IN MANY OF THE CASES REPORTED, SURGICAL INTERVENTION WAS REQUIRED AND, IN A SOME OF THESE CASES, PERMANENT IMPAIRMENT OF ERECTILE FUNCTION OR IMPOTENCE RESULTED. MALE PATIENTS WITH PROLONGED OR INAPPROPRIATE ERECTIONS SHOULD IMMEDIATELY DISCONTINUE THE DRUG AND CONSULT THEIR PHYSICIAN.
DailyMed: About DailyMed


Stryjer R, Spivak B, Strous RD, et al. Trazodone for the treatment of sexual dysfunction induced by serotonin reuptake inhibitors: a preliminary open-label study. Clin Neuropharmacol 2009;32(2):82-4.

INTRODUCTION: Treatment with selective serotonin reuptake inhibitors (SSRIs) may lead to sexual dysfunction in up to 70% of patients. Because the SSRIs are widely used antidepressants, their propensity to cause sexual dysfunction may affect compliance with therapy and ultimately treatment success. To date, the pathophysiological mechanism of sexual dysfunction caused by SSRIs remains incompletely understood, and the management of SSRIs-induced sexual dysfunction remains unsatisfactory. We suggest that medications that antagonize serotonin receptors such as trazodone may improve sexual dysfunction reverting the stimulation of serotonin receptors by SSRIs.

OBJECTIVE: The aim of this study was to investigate the efficacy of trazodone administration in the management of SSRI-induced sexual dysfunction. METHODS: Twenty patients (11 men/9 women) with SSRIs-induced sexual dysfunction were recruited for the study. Trazodone was added to the existing SSRI regimen in open-label fashion for 4 weeks (50 mg for the first week increased to 100 mg until the completion of the study). The improvement in the 4 dimensions of sexual function (desire, erection or lubrication problems in women, ejaculation or orgasm in women, and overall satisfaction by both sexes) was the primary outcome measure of the study.

RESULTS: Fifteen subjects completed the study. Results indicated improvement in sexual function and overall clinical improvement (depression, anxiety) as well. Specific gender differences indicated improvement in erectile performance in men and lubrication in women. No correlations were noted between clinical improvement of depression or anxiety and improvement in sexual dysfunction.

CONCLUSIONS: The 5-HT2 antagonist, trazodone, may be beneficial in the management of SSRI-induced sexual dysfunction. Large-scale, placebo-controlled, double-blind studies with 5-HT2 antagonists are required to substantiate these preliminary observations.


Thomas JA. Pharmacological aspects of erectile dysfunction. Jpn J Pharmacol 2002;89(2):101-12.

Erectile dysfunction (ED) is a common problem with a prevalence of approximately 50% in men aged 40 to 70. There are several etiologies for ED including vasculogenic, neurogenic, hormonal and/or psychogenic factors; one-fourth of ED cases can be drug-related. Penile erection involves a complex interaction between the CNS and local factors. It is a neurovascular event modulated by psychological and hormonal factors. Pharmacologically, neural modulation and endocrine status are very important to attaining penile erection. There have been several significant advances for the pharmacologic treatment of ED. Treatments include agents that are not only orally effective, but possess either local or central acting mechanisms of action. Apomorphine, a centrally-acting agent, is effective in the treatment of ED. Sildenafil, another orally effective agent, acts by inhibiting cyclic GMP-specific phosphodiesterase Type V. Testosterone can be effective transdermally. Non-orally active agents include alprostadil and papaverine. Phentolamine and trazodone are effective in selected cases. Some agents can interact with other medications. Several pharmacological agents, some with central-acting mechanisms and some with Iocally-acting vascular effects, are therapeutically useful in the treatment of ED.

 

[HeadDoc]

trazadone should never be used by men...........its major side effect is ED. It works well in women but even they report decreased orgasm........due to effect of nitric oxide release on the endothelium.

I'm at a loss on this one. Trazadone is one of the most frequently prescribed sleep aides for those with a potential to abuse drugs. It, like sinequan (ie doxepin) blocks the reuptake of norephinephrine. I assume that this is one of the reasons that it does not create sexual problems like the SSRI's. Where pripism is of concern, many of the docs that I have worked with will prescribe sinequan over trazadone for sleep. My second license is Substance Abuse. So it's a population that I work with frequently.

Are there any studies to reference on trazadone and an increase of ED?

 

[HeadDoc]

I'll have to correct part of what I stated. Trazadone acts as a serotonin antagonist at low dose and as a serotonin agonist at higher doses. In any event, I could find no lit. to support the sexual sides as the SSRi's do.

 

[BBC3]

I googled "Nitric Oxide and Trazadone". Not to give him any credibility beyond his general, seemingly ignorant statement, but it is interesting what comes up... In all my Trazadone research, I have never stumbled on to this line of study...

I'll have to correct part of what I stated. Trazadone acts as a serotonin antagonist at low dose and as a serotonin agonist at higher doses. In any event, I could find no lit. to support the sexual sides as the SSRi's do.

 

[bigrobbie]

WOW!!