metformin inhibits gains from aerobic exercise!?

[Hesoprimaltho]

https://onlinelibrary.wiley.com/doi/full/10.1111/acel.12880

Obviously we're quite different than the tested subjects as we're all enhanced to some degree, but nonetheless I found this interesting and would like to hear thoughts perhaps from some others that have taken metformin for any length of time for biohacking purposes.

TLDR

Metformin attenuates the improvement in physiological function after aerobic exercise training​

Metformin abolishes the improvement in mitochondrial respiration after aerobic exercise training​

 

[ar7353]

Subbed so that I can read this article and the comments when I have down time. Very interesting

 

[Metribolone]

Unrelated but slightly applicable to this topic, beta blockers also reduce the effectiveness of cardio. I remember going to my doc about tremors I’ve been dealing with as a teenager and he prescribed me propranolol (which didn’t help much) and told me that it would greatly reduce the effectiveness of cardio by preventing your heart rate from going up.

 

[Millard]

There was some discussion after the NYTimes ran a story about this study:

An Anti-Aging Pill? Think Twice (Published 2019)

The diabetes drug metformin, sometimes taken to slow aging, may blunt the health benefits of exercise.

www.nytimes.com

Here's the original paper:

Konopka AR, Laurin JL, Schoenberg HM, Reid JJ, Castor WM, Wolff CA, Musci RV, Safairad OD, Linden MA, Biela LM, Bailey SM, Hamilton KL, Miller BF. Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults. Aging Cell. 2019 Feb;18(1):e12880. doi: 10.1111/acel.12880. Epub 2018 Dec 11. PMID: 30548390; PMCID: PMC6351883.