Mixing tesamorelin and hgh

[undersc0re]

I know I might get blasted for even mentioning this….is it plausible to do tesamorelin in the morning, and then hgh before bed? Will the tesamorelin have additional benefits other than triggering hgh release. I have just moved up to 2 iu a day of hgh 5 days a week and that is where I will stay. Also wondering at the age of 53 if tesamorelin will trigger much of an hgh release and if it will help with other stuff other than what hgh does.

 

[Middus]

I know I might get blasted for even mentioning this….is it plausible to do tesamorelin in the morning, and then hgh before bed? Will the tesamorelin have additional benefits other than triggering hgh release. I have just moved up to 2 iu a day of hgh 5 days a week and that is where I will stay. Also wondering at the age of 53 if tesamorelin will trigger much of an hgh release and if it will help with other stuff other than what hgh does.

There is some suggestion that exogenous HGH temporarily suppresses Natural GH production so It's better to stick to 1.

Exogenous growth hormone inhibits growth hormone-releasing factor-induced growth hormone secretion in normal men - PMC (almost 40yr old study)

I'm able to get away with Tesa for now, but HGH will have greater effect, since tesamorelin's actions are due to GH production.

 

[Ghoul]

I know I might get blasted for even mentioning this….is it plausible to do tesamorelin in the morning, and then hgh before bed? Will the tesamorelin have additional benefits other than triggering hgh release. I have just moved up to 2 iu a day of hgh 5 days a week and that is where I will stay. Also wondering at the age of 53 if tesamorelin will trigger much of an hgh release and if it will help with other stuff other than what hgh does.

I'm making some broad generalizations here, since we don't know your baseline and I'm no expert on this topic.

2iu of HGH or 2mg of Tesa will, according to studies I've read, on average raise IGF by around 100.

Assuming you're around the mean for your age, 112, either would push you to the top of the normal range, which sounds ideal for anti-aging.

Personally I'd use Tesa alone for this purpose. Don't have the timing concerns of hgh, as long as you take Tesa at the same time each day, and it seems "safer" to me for long term (lifetime use). I like the idea of keeping natural GH release and regulation systems intact, but I don't have much to prove this is better than straight GH.

 

[undersc0re]

Thats what I want it for basically is anti-aging, I am older, work crazy random shift work, and never get good sleep.

 

[Middus]

Thats what I want it for basically is anti-aging, I am older, work crazy random shift work, and never get good sleep.

Then source good Tesa. That's what I use mine for.
Although for some dumb reason I take CJC in the morning and my Tesa in the evening. It's not based on advice, but rather sunken cost

 

[undersc0re]

Then source good Tesa. That's what I use mine for.
Although for some dumb reason I take CJC in the morning and my Tesa in the evening. It's not based on advice, but rather sunken cost

Yeah, going to finish off my hgh and transition to tesa, what is your tesa dosing schedule? Do you take a couple months off and do hgh in place like once a year so the body doesn’t become numb to the tesa…or can tesa be done year round?

 

[Ghoul]

Yeah, going to finish off my hgh and transition to tesa, what is your tesa dosing schedule? Do you take a couple months off and do hgh in place like once a year so the body doesn’t become numb to the tesa…or can tesa be done year round?

Tesamorelin is intended to be taken indefinitely, with fewer side effects than growth hormone. There's no evidence it loses effectiveness over time.

In fact, taking a "break", might be more likely to cause a loss of effectiveness vs staying on.

It's FDA approved use is for people with AIDS on anti-retroviral drugs, which lowers growth hormone causing visceral (organ) fat accumulation, and those drugs are taken for a lifetime, If Tesa is discontinued, the visceral fat returns.

It improves body composition, reduces liver fat, lowers cholesterol, and does this without increasing insulin resistance which is associated with long term GH treatment.

The benefits aren't as dramatic as GH, but it seems more sustainable. over long periods. I've noticed significant visible improvement to skin and nails in the 5 months I've been using it.

 

[undersc0re]

Good to know thanks.

 

[benfrankparkway]

Tesamorelin is intended to be taken indefinitely, with fewer side effects than growth hormone. There's no evidence it loses effectiveness over time.

In fact, taking a "break", might be more likely to cause a loss of effectiveness vs staying on.

It's FDA approved use is for people with AIDS on anti-retroviral drugs, which lowers growth hormone causing visceral (organ) fat accumulation, and those drugs are taken for a lifetime, If Tesa is discontinued, the visceral fat returns.

It improves body composition, reduces liver fat, lowers cholesterol, and does this without increasing insulin resistance which is associated with long term GH treatment.

The benefits aren't as dramatic as GH, but it seems more sustainable. over long periods. I've noticed significant visible improvement to skin and nails in the 5 months I've been using it.

I may consider this as well as GH has crippled me and after year and half of using it I wont go back. I have been reading on Tesa just same issues with anything, quality source and reliability of it being there.

 

[Ghoul]

I may consider this as well as GH has crippled me and after year and half of using it I wont go back. I have been reading on Tesa just same issues with anything, quality source and reliability of it being there.

I'd say the primary disadvantage of Tesa, for permanent, anti-aging use is the lack of a "pharma" option. But of course, most using GH aren't going pharma, and a good proportion of those who do spend for the assurance pharma produced GH are probably just getting UGL in counterfeit package.

Perhaps the guys who supply pharma products from outside the US can offer Egrifta for less than the $8,000 / mo US cost. It's eligible to be made as a generic, but no producer has stepped up to do it. The problem is the new aids drugs don't suppress GH the way the old ones do, so the population using Egrifta for its approved use is shrinking.

Unlike growth hormone, which cannot, by law, be prescribed for off-label uses, Egrifta can, If more docs prescribed it for anti-aging, high cholesterol, or fatty liver disease purposes, which it's demonstrated very good effectiness in treating, I'm sure the demand would justify a generic maker to spend the money getting a product approved for the market, and probably reduce the price to a few hundred a month,

Remember, unlike Sermorellin and Ipamorelin, Tesa is FDA approved and has 20 years of use demonstrating its relative safety. And instead of just shoving in extrogenous synthetic GH, you're producing your own, the best kind, along with numerous "side products" that are excreted with GH, many of which we don't know the purpose of, but likely evolved to accompany GH for a reason.

 

[benfrankparkway]

I'd say the primary disadvantage of Tesa, for permanent, anti-aging use is the lack of a "pharma" option. But of course, most using GH aren't going pharma, and a good proportion of those who do spend for the assurance pharma produced GH are probably just getting UGL in counterfeit package.

Perhaps the guys who supply pharma products from outside the US can offer Egrifta for less than the $8,000 / mo US cost. It's eligible to be made as a generic, but no producer has stepped up to do it. The problem is the new aids drugs don't suppress GH the way the old ones do, so the population using Egrifta for its approved use is shrinking.

Unlike growth hormone, which cannot, by law, be prescribed for off-label uses, Egrifta can, If more docs prescribed it for anti-aging, high cholesterol, or fatty liver disease purposes, which it's demonstrated very good effectiness in treating, I'm sure the demand would justify a generic maker to spend the money getting a product approved for the market, and probably reduce the price to a few hundred a month,

Remember, unlike Sermorellin and Ipamorelin, Tesa is FDA approved and has 20 years of use demonstrating its relative safety. And instead of just shoving in extrogenous synthetic GH, you're producing your own, the best kind, along with numerous "side products" that are excreted with GH, many of which we don't know the purpose of, but likely evolved to accompany GH for a reason.

just checking on dosage and price...Wow, doesn't seem worthwhile for the cost. a little more than double for what I was paying for GH.

 

[Ghoul]

just checking on dosage and price...Wow, doesn't seem worthwhile for the cost. a little more than double for what I was paying for GH.

Tesa, bought "correctly", ie on promo from you know who is $2 / day.

HGH is about half that now, for a 2iu dose,

Unfortunately Tesa hasn't followed the rapid drop in GH prices (that needs to be addressed if they want to keep selling it). However, for $350 more a year, I find the advantages in fewer potential sides, less restrictive timing (ie Tesa can be taken any time of day with similar results), and to me, a more "natural", safer, mechanism of action. The last point pure "feels" I'll admit.

One other more esoteric factor, there's likely a large group of GH users that have developed some degree of inhibition over time, effectively reducing the dose by xx%. While Tesa, although it is also highly immunogenic, doesn't seem to suffer the same attenuation of effect. In other words, the immune system freaks out, but is less capable of removing it from the body than GH.

 

[benfrankparkway]

Tesa, bought "correctly", ie on promo from you know who is $2 / day.

HGH is about half that now, for a 2iu dose,

Unfortunately Tesa hasn't followed the rapid drop in GH prices (that needs to be addressed if they want to keep selling it). However, for $350 more a year, I find the advantages in fewer potential sides, less restrictive timing (ie Tesa can be taken any time of day with similar results), and to me, a more "natural", safer, mechanism of action. The last point pure "feels" I'll admit.

One other more esoteric factor, there's a likely a large group of GH users that have developed some degree of inhibition over time, effectively reducing the dose by xx%. While Tesa, although it is also highly immunogenic, doesn't seem to suffer the same attenuation of effect. In other words, the immune system freaks out, but is less capable of removing it from the body than GH.

I will be looking to be buying it "correctly" now. Thank you for this, you have me sold

 

[Ghoul]

I will be looking to be buying it "correctly" now. Thank you for this, you have me sold

Not to gild the lilly, but since I use these posts to organize my own thoughts on topics, I'll add this recent observation.

Many of the studies measuring specific benefits of Tesa, like improvement in muscle density, reductions in lipids, etc, are independent of how much IGF has increased, which the researchers often note they can't explain, but present as a benefit vs GH treatment.

In other words, the technical expression that applies is "The mechanism of action has not been fully elucidated", which in my mind, suggests it's those "other things" that are released with GH that may be responsible for some of the benefits.

To put it another way, if 2iu of GH is roughly the "equivalent" of 2mg dose of Tesa, based on a similar average rise in IGF, let's say 100ng, it may be that Tesa is providing more benefits at that level of IGF than GH does, thanks to the "extra stuff" being released along with GH.

*this is all an amateur's hypothesis based on what I've read, so if there's some glaring error in my reasoning I apologize in advance.

 

[benfrankparkway]

Not to gild the lilly, but since I use these posts to organize my own thoughts on topics, I'll add this recent observation.

Many of the studies measuring specific benefits of Tesa, like improvement in muscle density, reductions in lipids, etc, are independent of how much IGF has increased, which the researchers often note they can't explain, but present as a benefit vs GH treatment.

In other words, the technical expression that applies is "The mechanism of action has not been fully elucidated", which in my mind, suggests it's those "other things" that are released with GH that may be responsible for some of the benefits.

To put it another way, if 2iu of GH is roughly the "equivalent" of 2mg dose of Tesa, based on a similar average rise in IGF, let's say 100ng, it may be that Tesa is providing more benefits at that level of IGF than GH does, thanks to the "extra stuff" being released along with GH.

*this is all an amateur's hypothesis based on what I've read, so if there's some glaring error in my reasoning I apologize in advance.

I dont have a long history of GH ususage. 4 different reputable brands all used over a year and half. All the way up to 6iu. Nothing was a drastic change. I wasnt shredded or added 15lbs of muscle. I took it for what other said to take it for and made observations along the way. In the 2 months I have been off I have noticed slower recovery, and less pumps. Body composition is a little softer but I blame that due to the holidays.

I got minor results and that's ok, I will take what I can get. I will try Tesa at some point and judge for myself if is worth the price. But like GH I will take what I can get. I feel and look good, at this point there is no more adding noticeable muscle without getting back on Test, etc...

 

[Ghoul]

I dont have a long history of GH ususage. 4 different reputable brands all used over a year and half. All the way up to 6iu. Nothing was a drastic change. I wasnt shredded or added 15lbs of muscle. I took it for what other said to take it for and made observations along the way. In the 2 months I have been off I have noticed slower recovery, and less pumps. Body composition is a little softer but I blame that due to the holidays.

I got minor results and that's ok, I will take what I can get. I will try Tesa at some point and judge for myself if is worth the price. But like GH I will take what I can get. I feel and look good, at this point there is no more adding noticeable muscle without getting back on Test, etc...

Tesa is certainly no sprint. The benefits were slow to build, just starting to be noticeable around 12 weeks, and much more pronounced by 20. The studies show improvement in visceral fat reduction and overall body composition max out at around a year, and are maintained with continued use,

So I'd say the "target audience" is different than GH. It's definitely for anti-agers, or cautious bodybuilders who prefer to avoid the pitfalls of GH but still reap the benefits of "optimized" physiologic growth hormone levels.

The next thing I'd like to figure out is how much higher can one safely go with Tesa. Pharma always has a generous dose safety margin, Like Tirz maxes out at 15mg, whether your a 100lb 5' female or a 300' 6' 4" male, while we know the latter can tolerate and likely benefit from a higher dose.

As far as I can establish, 2mg is it, the universal dose with no published data on higher amounts, even with IGF well below the top of the range for a given age. I'm sure that limit was established with the smallest potential patient in mind.

 

[undersc0re]

Is there anything you know of that absolutely should not be used along side tesa in terms of stuff people on this forum would use for health or body building? Like cialis, hcg, mast etc.

 

[songsofpyramids]

like improvement in muscle density, reductions in lipids, etc, are independent of how much IGF has increased

Hgh operates the same. Its benefits are also independent of igf increase as there’s all sorts of down stream impacts. You can see this when people are running something like tren while on hgh, which keeps igf fairly low but still gives the fat burning and muscle holding hgh normally would. I’m having a slightly rough day as it’s my first week on sema, so I’m sorry for this half assed response in this thread. Mostly commenting to come back and read and contribute when I’m more with it.

I would say that the major difference in hgh and tesa would be hgh having significantly more patient hours under its belt and more robust follow up studies just because it’s been around longer and used more. I’m also not entirely convinced revving your pituitary to squeeze out more gh is any safer than supplementing exogenous gh, as both seem to have pros and cons. Interesting thread will follow.

 

[songsofpyramids]

Is there anything you know of that absolutely should not be used along side tesa in terms of stuff people on this forum would use for health or body building? Like cialis, hcg, mast etc.

Tesa contraindications are in here https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/022505s000lbl.pdf

 

[Ghoul]

Is there anything you know of that absolutely should not be used along side tesa in terms of stuff people on this forum would use for health or body building? Like cialis, hcg, mast etc.

Because Tesa was primarily tested on a pretty sickly population, a lot of potential drug interactions were observable in trials. A lot of subjects were on AAS, ie, Testosterone.

TLDR, if you're taking any diabetes drug, keep an eye on glucose levels. That's about it.

It's also mentioned that if you have a disease impacting the HPA axis, it may not be suitable. Given that growth hormone does this, perhaps best to avoid combing them.

Here are the drug interactions.

Tesamorelin Drug Interactions - Drugs.com

48 drugs are known to interact with tesamorelin.

www.drugs.com