fodsod
Well-known Member
I'd cap my own too but I'm lazy about it. Are you using a filler also or just dosing the powder straight into the caps individually?
MESO-Rx
Anabolic Steroids
MK-677
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Marcus
New Member
It's actually liquid directly in there. Just ordered some powder from overseas that I'll cap for use. I don't see the advantage in using a filler with the powder... is there one?
fodsod
Well-known Member
I got you now. Usually when one is doing the caps in bulk with a press you use a filler to mix the powder with to ensure proper dosing for all the caps.
I'm lazy but the guys I've seen making the caps for pretty much everything use creatine, dextrose, rice flour, regular flour, corn starch or bone glue (yep, gross. But it's cheap and some of the RC companies use it in their caps as filler or part of the filler).
Mustang_18
New Member
Capping them is definitely the way to go. I didn't even bother giving the liquid a shot. If you do it correctly, the caps are easy to dose and you barley taste it if at all.
D
Deleted member 59947
Guest
Straight powder!
I couldn't imagine having to endure the taste even longer by mixing it in a liquid
Mustang_18
New Member
Just a speed factor... if doing a couple hundred, dosing them individually would take forever. If you can find a cheap capper that does 50-100 at a time, it's definitely worth the small investment. I used Blue Rasberry BCAAs as a filler. Reason being, I hoped it would dilute the taste and the off colour would visually allow me to see it mixed consistently. I've been on 30mg day for the past 5-6 months so it's been well worth it for me from a cost standpoint to do it this way.
Marcus
New Member
What kind of results have you seen man? Any bloodwork?
Mustang_18
New Member
I haven't gotten any bloods done although I probly should... now, because I'm also running GH, it wouldn't really give me a good indication of what was from the MK and what's from the GH. The first 2 months was MK only. I started about 245lbs and put on about 7lbs in the first week without any change in diet. My appetite was through the roof and I was lethargic for a good portion of the day (even though I take it at night) After about 2-3 weeks my appetite was back to normal and I was functional again. The one thing I noticed most was my sleep was nothing short of amazing. I've always had fairly severe insomnia and it stopped almost instantly. I'll have the occasional night where I'm restless but nothing compared to what it once was. Even after close to 6 months, it still seems to be working great. I ran 15mg day for the first 2 months then increased to 30mg which is where I'll stay. The addition of the Gh only magnified my results. As far as muscle gains and fat loss goes, it definitely help change body composition although I can't attribute it to the MK 100% as obviously the diet and consistency played a big role as well.
So I was trying to listen to my own advice and cut my mk dose and half. Well been on 450mg tren ace a week for about 5 weeks was sleeping fine. 2 weeks since cutting dose I have been sleeping like shit. Going back up starting tonight. Been going over the log book trying to figure it out, finally realized that's when it started.
fodsod
Well-known Member
What was your dose prior to cutting it back (I'm too lazy to go back and look it up)? I run 45mg ED and that seems to help off set the tren sleep issue as long as my tren dose isn't above 700 mg per week.
50mg, cut back to 25mg.
Mayne
Well-known Member
MK6 is alright if mixed with Olive Oil and a bit of ethanol? I have no access to 95% would like 70% still do? I am not a fan of capping my other option would be to raw and chase I am not sure I would do that reading it has a taste of shit so I think I would opt for liquid solution or is it suspension?
Buy some ora sweet and ora plus and mix it in that. Available on amazon
Mayne
Well-known Member
Not in the EU.
lukk3395
New Member
MK in my personal experience works. I have run 25 mg a day for 6 months and I have really seen that it is harder to pick up fat and recovery is better along with sleep quality
Growth hormone secretagogue MK-677: no clinical effect on AD progression in a randomized trial. - PubMed - NCBI
BACKGROUND: In animals, insulin-like growth factor-1 (IGF-1) increases clearance of beta-amyloid, a pathologic hallmark of Alzheimer disease (AD), from the CNS. Serum IGF-1 level decreases with age, and shows a further decrease in AD. We examined whether the growth hormone secretagogue MK-677 (ibutamoren mesylate), a potent inducer of IGF-1 secretion, slows the rate of progression of symptoms in patients with AD.
METHODS: A double-blind, multicenter study was conducted in which 563 patients with mild to moderate AD were randomized to receive MK-677 25 mg or placebo daily for 12 months. Efficacy measures were mean change from baseline at month 12 on the Clinician's Interview Based Impression of Change with caregiver input (CIBIC-plus), the cognitive subscale of the Alzheimer's Disease Assessment Scale (ADAS-Cog), Alzheimer's Disease Cooperative Study-Activities of Daily Living (ADCS-ADL), and the Clinical Dementia Rating-sum of boxes (CDR-sob).
RESULTS: A total of 416 patients completed treatment and assessments at 12 months. Administration of MK-677 25 mg resulted in a 60.1% increase in serum IGF-1 levels at 6 weeks and a 72.9% increase at 12 months. In mixed-effects models that included treatment, time (month), randomization strata (baseline MMSE score < or =20 vs >20), and interaction of treatment-by-time, there were no significant differences between the treatment groups on the CIBIC-plus or the mean change from baseline scores on the ADAS-Cog, ADCS-ADL, or CDR-sob scores over 12 months.
CONCLUSION: Despite evidence of target engagement as indicated by an increase in serum insulin-like growth factor-1, the human growth hormone secretagogue MK-677 25 mg was ineffective at slowing the rate of progression of Alzheimer disease.
PMID
19015485 [PubMed - indexed for MEDLINE]
Full text
Dont know whether this study has already been posted but to me it is probably one of the best ones out there, because it actually talks and investigates whether mk677 remains active for longer periods of time, whereas most other studys just look at a six to twelve week time frame.
BACKGROUND: In animals, insulin-like growth factor-1 (IGF-1) increases clearance of beta-amyloid, a pathologic hallmark of Alzheimer disease (AD), from the CNS. Serum IGF-1 level decreases with age, and shows a further decrease in AD. We examined whether the growth hormone secretagogue MK-677 (ibutamoren mesylate), a potent inducer of IGF-1 secretion, slows the rate of progression of symptoms in patients with AD.
METHODS: A double-blind, multicenter study was conducted in which 563 patients with mild to moderate AD were randomized to receive MK-677 25 mg or placebo daily for 12 months. Efficacy measures were mean change from baseline at month 12 on the Clinician's Interview Based Impression of Change with caregiver input (CIBIC-plus), the cognitive subscale of the Alzheimer's Disease Assessment Scale (ADAS-Cog), Alzheimer's Disease Cooperative Study-Activities of Daily Living (ADCS-ADL), and the Clinical Dementia Rating-sum of boxes (CDR-sob).
RESULTS: A total of 416 patients completed treatment and assessments at 12 months. Administration of MK-677 25 mg resulted in a 60.1% increase in serum IGF-1 levels at 6 weeks and a 72.9% increase at 12 months. In mixed-effects models that included treatment, time (month), randomization strata (baseline MMSE score < or =20 vs >20), and interaction of treatment-by-time, there were no significant differences between the treatment groups on the CIBIC-plus or the mean change from baseline scores on the ADAS-Cog, ADCS-ADL, or CDR-sob scores over 12 months.
CONCLUSION: Despite evidence of target engagement as indicated by an increase in serum insulin-like growth factor-1, the human growth hormone secretagogue MK-677 25 mg was ineffective at slowing the rate of progression of Alzheimer disease.
PMID
19015485 [PubMed - indexed for MEDLINE]
Full text
Dont know whether this study has already been posted but to me it is probably one of the best ones out there, because it actually talks and investigates whether mk677 remains active for longer periods of time, whereas most other studys just look at a six to twelve week time frame.
Mayne
Well-known Member
Are your MK-667 raws meant to be put into capsules? The comment on the product is something I have never heard of before:
"Dissolve in water first... It contains benzyl chloroformate which is highly toxic"
Any info on this or?
"Dissolve in water first... It contains benzyl chloroformate which is highly toxic"
Any info on this or?
Marcus
New Member
I assume this was meant for PPL thread? Everyone is kinda wondering the same thing with this.
Benzyl chloroformate is a liquid from what I'm reading, so what? They maybe use it to synthesize the MK and then it solidifies or something?
Mayne
Well-known Member
I have no idea I just read an year old post on reddit about it not sure if it's actual now...
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