Mod GRF 1-29 + IPM + BPC-157 + TB-500 + GHK-CU stack, beginner questions

[durrcat]

So I'm drawing up an injury recovery stack for my partner to try and help him with some residual issues following a cartilage repair on his knee after a long period of being housebound. its 2 years out from the op and hes still experiencing a fair bit of weakness and pain in the joint. he isnt willing to try AAS yet, but ive suggested a peptide based recovery stack to him and hes willing to try that. i would like to ask some basic questions about dosing, reconstitution, etc on this. my concerns are helping with ligament, muscle, and nerve weakness, and maximising any possible collagen repair we might be able to induce.

the stack i have in mind is as follows:
mod GRF 1-29 + ipamorelin .2+.2mg once daily
BPC-157 + TB-500 .5mg+.5mg subq once daily
GHK-CU 2mg subq once daily


the TB-500 and BPC-157 doses i am thinking of dont seem ideal on account of the 1:1 mixture i will be purchasing it in, could i be dosing these better?

i know that the rapid reduction of circulating GHK-CU means it would be better suited to multiple injections a day, however his work situation makes injections that frequent not viable. as i understand it the half life puts him above literature suggested therapeutic doses for about 7 hours @ 2mg/injection (DOI: 10.1155/2015/648108, US20230088926A1). hopefully thats enough.

one other odd question i have, is whether it would be sensible to mix the GH peptides and the BPC-157 + TB-500 into one vial for the purpose of injection. specifically, im thinking of buying some insulin pens and vials, and transferring the peptides out of the constituted vials into the insulin pen vial at appropriate volumes for the desired dose. for obvious reasons the copper peptide will be kept seperate. my concern is, do i risk interactions between the peptides and potential denaturing if i do this?

 

[Ateam2023]

So I'm drawing up an injury recovery stack for my partner to try and help him with some residual issues following a cartilage repair on his knee after a long period of being housebound. its 2 years out from the op and hes still experiencing a fair bit of weakness and pain in the joint. he isnt willing to try AAS yet, but ive suggested a peptide based recovery stack to him and hes willing to try that. i would like to ask some basic questions about dosing, reconstitution, etc on this. my concerns are helping with ligament, muscle, and nerve weakness, and maximising any possible collagen repair we might be able to induce.

the stack i have in mind is as follows:
mod GRF 1-29 + ipamorelin .2+.2mg once daily
BPC-157 + TB-500 .5mg+.5mg subq once daily
GHK-CU 2mg subq once daily


the TB-500 and BPC-157 doses i am thinking of dont seem ideal on account of the 1:1 mixture i will be purchasing it in, could i be dosing these better?

i know that the rapid reduction of circulating GHK-CU means it would be better suited to multiple injections a day, however his work situation makes injections that frequent not viable. as i understand it the half life puts him above literature suggested therapeutic doses for about 7 hours @ 2mg/injection (DOI: 10.1155/2015/648108, US20230088926A1). hopefully thats enough.

one other odd question i have, is whether it would be sensible to mix the GH peptides and the BPC-157 + TB-500 into one vial for the purpose of injection. specifically, im thinking of buying some insulin pens and vials, and transferring the peptides out of the constituted vials into the insulin pen vial at appropriate volumes for the desired dose. for obvious reasons the copper peptide will be kept seperate. my concern is, do i risk interactions between the peptides and potential denaturing if i do this?

theres a "new member introduction thread" you should visit and " introduce yourself" to the community,,,,, Proper forum etiquette,,,,,

 

[durrcat]

theres a "new member introduction thread" you should visit and " introduce yourself" to the community,,,,, Proper forum etiquette,,,,,

sorry, i havent used a BBS in like a decade
done

 

[RandallFlagg]

So I'm drawing up an injury recovery stack for my partner to try and help him with some residual issues following a cartilage repair on his knee after a long period of being housebound. its 2 years out from the op and hes still experiencing a fair bit of weakness and pain in the joint. he isnt willing to try AAS yet, but ive suggested a peptide based recovery stack to him and hes willing to try that. i would like to ask some basic questions about dosing, reconstitution, etc on this. my concerns are helping with ligament, muscle, and nerve weakness, and maximising any possible collagen repair we might be able to induce.

the stack i have in mind is as follows:
mod GRF 1-29 + ipamorelin .2+.2mg once daily
BPC-157 + TB-500 .5mg+.5mg subq once daily
GHK-CU 2mg subq once daily


the TB-500 and BPC-157 doses i am thinking of dont seem ideal on account of the 1:1 mixture i will be purchasing it in, could i be dosing these better?

i know that the rapid reduction of circulating GHK-CU means it would be better suited to multiple injections a day, however his work situation makes injections that frequent not viable. as i understand it the half life puts him above literature suggested therapeutic doses for about 7 hours @ 2mg/injection (DOI: 10.1155/2015/648108, US20230088926A1). hopefully thats enough.

one other odd question i have, is whether it would be sensible to mix the GH peptides and the BPC-157 + TB-500 into one vial for the purpose of injection. specifically, im thinking of buying some insulin pens and vials, and transferring the peptides out of the constituted vials into the insulin pen vial at appropriate volumes for the desired dose. for obvious reasons the copper peptide will be kept seperate. my concern is, do i risk interactions between the peptides and potential denaturing if i do this?

I just found your question and no one circled back to it. Hopefully you got sorted.

My personal quick thoughts/opinions:

1.) just go with HGH at like 2-4 IU (though I should probably ask you more questions about your partners age, other health issues etc.)
- I realize not everyone wants to jump to that and if your partner is under 40 then probably smarter to go with your Sermorelin plan.
- Ive used Tesamorelin and Ipamorelin but cost:benefit kept my from running it long term.
- pretty sure @Ghoul has given a solid rundown on some of the GHRPs etc. and his opinion...and his logic for being strongly in the Tesamorelin camp at least to start
- obviously would be ideal to get IGF-1 testing done, CRP, some other blood markers before pondering adding GH.

2.) not sure what you gain right off by using both Sermorelin and Ipamorelin.... aren't they both GH secretaogues? I may be just unfamiliar enough to know why you run both of what gain

3.) TB-500 - I'll assume it's the TB4 variant with the shorter half life (in which case imagine daily dosing is fine). BPC157 dosing sounds fine - just watch out for anhedonia (not to over blow the side effects as plenty of peeps here use it just fine...and one dude runs something like 10-20 mg but he seems like a very unique physiological specimen.

4.) GHK,-Cu: I would recommend add in about 30 mg of Zinc daily but just do a quick search on that to make sure I'm right.

5.) I would never combine peptides personally. I like being able to tweak doses and don't like losing flexibility (and its another variable to worry about with peptide.stability). But again that's all personal preference

Hope these opinions don't arrive too late. Hopefully someone smarter than me will chime in. Good luck!

 

[durrcat]

I just found your question and no one circled back to it. Hopefully you got sorted.

My personal quick thoughts/opinions:

1.) just go with HGH at like 2-4 IU (though I should probably ask you more questions about your partners age, other health issues etc.)
- I realize not everyone wants to jump to that and if your partner is under 40 then probably smarter to go with your Sermorelin plan.
- Ive used Tesamorelin and Ipamorelin but cost:benefit kept my from running it long term.
- pretty sure @Ghoul has given a solid rundown on some of the GHRPs etc. and his opinion...and his logic for being strongly in the Tesamorelin camp at least to start
- obviously would be ideal to get IGF-1 testing done, CRP, some other blood markers before pondering adding GH.

2.) not sure what you gain right off by using both Sermorelin and Ipamorelin.... aren't they both GH secretaogues? I may be just unfamiliar enough to know why you run both of what gain

3.) TB-500 - I'll assume it's the TB4 variant with the shorter half life (in which case imagine daily dosing is fine). BPC157 dosing sounds fine - just watch out for anhedonia (not to over blow the side effects as plenty of peeps here use it just fine...and one dude runs something like 10-20 mg but he seems like a very unique physiological specimen.

4.) GHK,-Cu: I would recommend add in about 30 mg of Zinc daily but just do a quick search on that to make sure I'm right.

5.) I would never combine peptides personally. I like being able to tweak doses and don't like losing flexibility (and its another variable to worry about with peptide.stability). But again that's all personal preference

Hope these opinions don't arrive too late. Hopefully someone smarter than me will chime in. Good luck!

1&2) some of my choices on this are a tad constrained by availability. IPA + GRF 1-29 was cheap and easy to obtain, til sales wiped out its availability. ive gone with CJC-1295 DAC instead because fuck it might as well take what i can get.

dosing for CJC-1295 DAC im probably going with 20mcg/kg as it seems to produce about a 150-200% increase in IGF-1, which (i havent dug into this yet) should probably imply a similar increase in GH i would think. were both in our early 30s so not too far into the GH decline as of yet.

3) for the TB-500, i would assume so yes. all i know of the vial is its generic TB-500 from china.

ive never actually encountered ahedonia with BPC-157, but i will closely watch my partners response to it to make sure hes doing alright.

4) i trust daily oral zinc supplementation is adequate there?

5) yeah makes sense. ive a good stock of insulins and such on hand so no real need need to combine off the bat when i should be honing in my doses.

 

[RandallFlagg]

1&2) some of my choices on this are a tad constrained by availability. IPA + GRF 1-29 was cheap and easy to obtain, til sales wiped out its availability. ive gone with CJC-1295 DAC instead because fuck it might as well take what i can get.

dosing for CJC-1295 DAC im probably going with 20mcg/kg as it seems to produce about a 150-200% increase in IGF-1, which (i havent dug into this yet) should probably imply a similar increase in GH i would think. were both in our early 30s so not too far into the GH decline as of yet.

3) for the TB-500, i would assume so yes. all i know of the vial is its generic TB-500 from china.

ive never actually encountered ahedonia with BPC-157, but i will closely watch my partners response to it to make sure hes doing alright.

4) i trust daily oral zinc supplementation is adequate there?

5) yeah makes sense. ive a good stock of insulins and such on hand so no real need need to combine off the bat when i should be honing in my doses.

TB-500...I've not gone too far down the rabbit hole in this but I think ACTUAL TB-500 is a lot more expensive than the TB-4 (multiple peeps on here have described this...i seldom use TB-500 to dig into the semantics).

Actual TB-500 has a longer half life and I think is usually only dosed 2-3x/week.

As for Zinc - I settled on Zinc picolinate 30 mg orally once daily when I take GHK-Cu. I would have dig back in as to why but that was the one I went with...lol. I don't take zinc routinely except when taking GHK-Cu. (I'm sure there's a reason I do this too..presumably because it's unnecessary for long term zinc supplementation).

I would avoid CJC 1295 with DAC...but thats just my opinion. I haven't used it much but personally felt w/out DAC was the way to go.

Truthfully, I'm sorta trying to bump this thread for you to get more opinions than mine...lol.

I wish I could point to hours of exhaustive research...I did look into all of these at one point but my knowledge is rusty right now.

 

[Ateam2023]

for reference , ive been dosing TB500 (full chain) everyday at 3 mg in the am, and i will say that my "lagging" healing process in left elbow (had ulner nerve release/carpul tunnel surgery) on October 2, has definitely been a game changer as far as discomfort/pain improvement etc,,,,

 

[UncleBuns]

I'd swap the CJC and Ipam for GH. Up the TB500 to at least 5mg a week.

You can try mixing them. Might need a bigger vial than what they come in though. Sometimes things go cloudy because of other ingredients or the filler used and each vendor does things a bit different. IME those mix fine, but I have not used GHK so not sure on that one. Make sure to use plenty of BA water.

Besides peptides what else is he doing for recovery? PT? Diet? Sleep? Etc.

 

[Benf15harp]

@RandallFlagg “and one dude runs something like 10-20 mg but he seems like a very unique physiological specimen.” Lol

 

[Benf15harp]

for reference , ive been dosing TB500 (full chain) everyday at 3 mg in the am, and i will say that my "lagging" healing process in left elbow (had ulner nerve release/carpul tunnel surgery) on October 2, has definitely been a game changer as far as discomfort/pain improvement etc,,,,

Glad that’s working man.
How exactly does one know if it’s full chain or not?
If I’m using the cheap shitty stuff I’m gonna be pissed on day 1 ‘25 lol

 

[Ateam2023]

Unless your getting GA tb500 frag , thats the only place that i know of selling the fragment version, im sure theres others but im unaware of them,,,

 

[Ateam2023]

I just switched to the full chain tb500 and notice ALOT more relief compared to the frag version,,,

 

[Benf15harp]

I just switched to the full chain tb500 and notice ALOT more relief compared to the frag version,,,

Im confused. Tb4 is the lesser of the two, correct?
I use the GA tb500 bc it wasn’t tb4 according to jano

 

[Benf15harp]

Im confused. Tb4 is the lesser of the two, correct?
I use the GA tb500 bc it wasn’t tb4 according to jano View attachment 309908

I’ve been duped. Lmao
Throwing this sheeit into the ocean.

 

[UncleBuns]

Unless your getting GA tb500 frag , thats the only place that i know of selling the fragment version, im sure theres others but im unaware of them,,,

SBB and lobster sell real frag as well.

 

[Ateam2023]

SBB and lobster sell real frag as well.

tbh, i'm getting more of a "relief/benefit" from the full sequence tb , it really has helped ALOT,,,,

 

[UncleBuns]

tbh, i'm getting more of a "relief/benefit" from the full sequence tb , it really has helped ALOT,,,,

Full sequence isn't better or worse. It just has more effects, some of which are desirable for some people. If you want this specific soft tissue/ tendon and ligament healing then frag is the way to go but full sequence dosedose other things that are useful.

 

[RandallFlagg]

@RandallFlagg “and one dude runs something like 10-20 mg but he seems like a very unique physiological specimen.” Lol

Hey don't get me wrong...I still hold out hope you're actually Martina (not Navritalova...no offense..lol) or AK so technically I made a leap with "dude."... I mean, you all play tennis so "close enough."

 

[durrcat]

TB-500...I've not gone too far down the rabbit hole in this but I think ACTUAL TB-500 is a lot more expensive than the TB-4 (multiple peeps on here have described this...i seldom use TB-500 to dig into the semantics).

Actual TB-500 has a longer half life and I think is usually only dosed 2-3x/week.

As for Zinc - I settled on Zinc picolinate 30 mg orally once daily when I take GHK-Cu. I would have dig back in as to why but that was the one I went with...lol. I don't take zinc routinely except when taking GHK-Cu. (I'm sure there's a reason I do this too..presumably because it's unnecessary for long term zinc supplementation).

I would avoid CJC 1295 with DAC...but thats just my opinion. I haven't used it much but personally felt w/out DAC was the way to go.

Truthfully, I'm sorta trying to bump this thread for you to get more opinions than mine...lol.

I wish I could point to hours of exhaustive research...I did look into all of these at one point but my knowledge is rusty right now.

I see. Injury recovery is sort of something im not looking into for myself actively so thanks for letting me know about this. ill probably quiz my source for details on the specifics once its arrived and i know theyre not gonna rug pull me on my meds.

bumps are def appreciated

 

[durrcat]

I'd swap the CJC and Ipam for GH. Up the TB500 to at least 5mg a week.

You can try mixing them. Might need a bigger vial than what they come in though. Sometimes things go cloudy because of other ingredients or the filler used and each vendor does things a bit different. IME those mix fine, but I have not used GHK so not sure on that one. Make sure to use plenty of BA water.

Besides peptides what else is he doing for recovery? PT? Diet? Sleep? Etc.

diet is very veg and meat oriented. lot of gravy roasts and stir fry type meals.
sleep is mixed, he works long days so typically 4-6 hours a day, sometimes more to catch up on sleep. physically ideally hed visit the gym more or at least use his weights more, but physical job and such. when i get him on this ill probably insist he do more in that department, do what i can to make it more viable for him to go use his weights. that said, the sort of strain that seems to benefit him the most is the kind he can only really get from working the right kind of job where weak muscles and ligaments can be made to work, and blood flow is elevated and sustained.