Calorie intake is still the dominant driver of fat loss. The glucagon-mediated increase in energy expenditure is real, but modest, and it doesn’t replace the need for a caloric deficit. Once you’re at a dose that lets you hit your target calories with minimal effort, pushing higher gives rapidly diminishing returns.
At higher doses, some people do see slightly higher energy expenditure and better nutrient partitioning, but it’s nowhere near enough to offset uncontrolled intake. If appetite suppression levels off around ~8 mg for you, moving to 12-15 mg is unlikely to meaningfully change fat loss unless it actually changes your eating behavior.
Some people get more appetite suppression at higher doses, others don’t. Once appetite is already low, there’s no extra lever to pull. More drug at that point doesn’t mean more fat loss, just higher cost and higher risk of side effects like GI issues, fatigue, sleep disruption, or elevated heart rate.
Thus, the sensible approach is to use the lowest dose that reliably lets you stick to your calorie target, then let consistency and time do the work. Higher dosing only makes sense if it changes intake or sustainability, not because of theoretical metabolic effects.
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