Well, all due respect, an n=1 reporting positive effects isn't any more convincing than many claiming 0 effects. Placebo effect can be a mofo to distinguish in a small sample size. And you do acknowledge snorting so that's already different than mere oral ingestion.
But if you do indeed get benefit from it, then don't let me stop me.
There is some data but granted very little. This is in mice but it does evaluate oral bioavailability. SR9009 is compound 3 in this study.
Optimized Chemical Probes for REV-ERBα
REV-ERBα has emerged as an important target for regulation of circadian rhythm and its associated physiology. Herein, we report on the optimization of a series of REV-ERBα agonists based on GSK4112 (1) for potency, selectivity, and bioavailability. ...
www.ncbi.nlm.nih.gov
"The IV and oral DMPK profiles of compounds 3, 4, 10, 16, and 23 were evaluated...Four of the compounds demonstrated essentially identical profiles with short half-lives, high clearance, and low oral bioavailability...The remaining four compounds (3, 10, 16, 23) would be suitable for acute time-of-day dosing by injection where short exposure of the compound at meaningful levels in desired."
This table shows the oral bioavailability is 2.2%.
Optimized Chemical Probes for REV-ERBα
REV-ERBα has emerged as an important target for regulation of circadian rhythm and its associated physiology. Herein, we report on the optimization of a series of REV-ERBα agonists based on GSK4112 (1) for potency, selectivity, and bioavailability. ...
www.ncbi.nlm.nih.gov
