Muscular Strength As A Predictor Of All-Cause Mortality

Michael Scally MD

Doctor of Medicine
10+ Year Member
García-Hermoso A, Cavero-Redondo I, Ramírez-Vélez R, et al. Muscular strength as a predictor of all-cause mortality in apparently healthy population: a systematic review and meta-analysis of data from approximately 2 million men and women. Archives of Physical Medicine and Rehabilitation 2018. http://www.sciencedirect.com/science/article/pii/S0003999318300790

Objective The aim of the present systematic review and meta-analysis was to determine the relationship between muscular strength and all-cause mortality risk and to examine the sex-specific impact of muscular strength on all-cause mortality in apparently healthy population.

Data Sources Two authors systematically searched MEDLINE, EMBASE and SPORTDiscus databases and conducted manual searching of reference lists of selected articles. Study Selection Eligible cohort studies were those that examined the association of muscular strength with all-cause mortality in apparently healthy population. The hazard ratio (HR) estimates with 95% confidence interval (CI) were pooled by using random effects meta-analysis models after assessing heterogeneity across studies.

Data extraction Two authors independently extracted data.

Data Synthesis Thirty-eight studies with 1,907,580 participants were included in the meta-analysis. The included studies had a total of 63,087 deaths. Higher levels of handgrip strength were associated with a reduced risk of all-cause mortality (HR= 0.69; 95% CI, 0.64–0.74) compared to lower muscular strength, with a slightly stronger association in women (HR= 0.60; 95% CI, 0.51–0.69) than men (HR= 0.69; 95% CI, 0.62–0.77) (all p<0.001). Also, adults with higher levels of muscular strength, as assessed by knee extension strength test, had a 14% lower risk of death (HR= 0.86: 95% CI, 0.80–0.93; p < 0.001) compared to adults with lower muscular strength.

Conclusions Higher levels of upper- and lower-body muscular strength are associated with a lower risk of mortality in adult population, regardless of the age and follow-up period. Muscular strength tests can be easily performed to identify people with a lower muscular strength and, consequently, with an increased risk of mortality.
 
García-Hermoso A, Cavero-Redondo I, Ramírez-Vélez R, et al. Muscular strength as a predictor of all-cause mortality in apparently healthy population: a systematic review and meta-analysis of data from approximately 2 million men and women. Archives of Physical Medicine and Rehabilitation 2018. http://www.sciencedirect.com/science/article/pii/S0003999318300790

Objective The aim of the present systematic review and meta-analysis was to determine the relationship between muscular strength and all-cause mortality risk and to examine the sex-specific impact of muscular strength on all-cause mortality in apparently healthy population.

Data Sources Two authors systematically searched MEDLINE, EMBASE and SPORTDiscus databases and conducted manual searching of reference lists of selected articles. Study Selection Eligible cohort studies were those that examined the association of muscular strength with all-cause mortality in apparently healthy population. The hazard ratio (HR) estimates with 95% confidence interval (CI) were pooled by using random effects meta-analysis models after assessing heterogeneity across studies.

Data extraction Two authors independently extracted data.

Data Synthesis Thirty-eight studies with 1,907,580 participants were included in the meta-analysis. The included studies had a total of 63,087 deaths. Higher levels of handgrip strength were associated with a reduced risk of all-cause mortality (HR= 0.69; 95% CI, 0.64–0.74) compared to lower muscular strength, with a slightly stronger association in women (HR= 0.60; 95% CI, 0.51–0.69) than men (HR= 0.69; 95% CI, 0.62–0.77) (all p<0.001). Also, adults with higher levels of muscular strength, as assessed by knee extension strength test, had a 14% lower risk of death (HR= 0.86: 95% CI, 0.80–0.93; p < 0.001) compared to adults with lower muscular strength.

Conclusions Higher levels of upper- and lower-body muscular strength are associated with a lower risk of mortality in adult population, regardless of the age and follow-up period. Muscular strength tests can be easily performed to identify people with a lower muscular strength and, consequently, with an increased risk of mortality.

@Michael Scally MD I don't understand any of your posts, I imagine they're useless entirely to most members and although the content could be very interesting or helpful, you post in a way as if you where talking with a forum of Medical doctors and we're not. I have a 4 year degree from a university, but your posts are still way over my head, 9 times out of ten.

You post really good info, if you could further break it down into layman's terms and make it easier to read I believe it would be a much greater benefit to the ENTIRE community.

Its not just this post, (which isn't as difficult to understand as your others) but all of your posts.

Please consider what I'm saying.
And remember that the community you're trying to help, and also taking apart of is not a group of medical doctors or professionals and although I genuinely believe you have good intentions, It is just very difficult to take anything away from the majority of your posts. And again, I'm someone with a 4 year degree from a top University.

Please consider what im saying, Thank you for your time.
 
@Michael Scally MD I don't understand any of your posts, I imagine they're useless entirely to most members and although the content could be very interesting or helpful, you post in a way as if you where talking with a forum of Medical doctors and we're not. I have a 4 year degree from a university, but your posts are still way over my head, 9 times out of ten.

You post really good info, if you could further break it down into layman's terms and make it easier to read I believe it would be a much greater benefit to the ENTIRE community.

Its not just this post, (which isn't as difficult to understand as your others) but all of your posts.

Please consider what I'm saying.
And remember that the community you're trying to help, and also taking apart of is not a group of medical doctors or professionals and although I genuinely believe you have good intentions, It is just very difficult to take anything away from the majority of your posts. And again, I'm someone with a 4 year degree from a top University.

Please consider what im saying, Thank you for your time.

DFgrA7AXoAAyPGh.jpg
 
@Michael Scally MD I don't understand any of your posts, I imagine they're useless entirely to most members and although the content could be very interesting or helpful, you post in a way as if you where talking with a forum of Medical doctors and we're not. I have a 4 year degree from a university, but your posts are still way over my head, 9 times out of ten.

You post really good info, if you could further break it down into layman's terms and make it easier to read I believe it would be a much greater benefit to the ENTIRE community.

Its not just this post, (which isn't as difficult to understand as your others) but all of your posts.

Please consider what I'm saying.
And remember that the community you're trying to help, and also taking apart of is not a group of medical doctors or professionals and although I genuinely believe you have good intentions, It is just very difficult to take anything away from the majority of your posts. And again, I'm someone with a 4 year degree from a top University.

Please consider what im saying, Thank you for your time.

It takes time and study to understand some of this stuff. But sometimes it is so blazingly obvious that it can be missed. Many studies border on the absurd but in the name of 'reductionism', even the obvious must be established through testing to either disprove or be a building block for more important things. Its like, "Is the sky blue?" ... yes, as a perception it is ... and now can we please get on to cosmology, hyper-novas, quazars, and string theory?

One of the best things to do with these studies is just read the conclusion and then the aim of study. To quote this one, "Conclusions Higher levels of upper- and lower-body muscular strength are associated with a lower risk of mortality in adult population, regardless of the age and follow-up period. Muscular strength tests can be easily performed to identify people with a lower muscular strength and, consequently, with an increased risk of mortality."

To paraphrase it: Muscular strength is an indicator of longevity. Weak arms and/or legs indicate weak health and shorter life. Strong arms and legs correlate to longer life.

This is an understanding already known in the health care community. Just ask a Physical Therapist if hand-grip-strength has been connected lifespan and they will likely say 'yes'. Yet the study has excellent statistic value (though obvious) because it had ~2,000,000 people instead of a handful of 'testimonials'. It is useful ammunition for the use of testosterone since it increases strength, so should be of interest to this community. Being (and staying stronger) might make you live longer.


Even though you have a college education, every field has its own lingo and volumes of information. So to learn about neurons, get ready for a headache and lots of time. To learn about genetics, another headache, etc. It can be a pain in the butt, but once you start understanding the basics of the field, you will begin understanding why it is that way.


The doctor as been around a long time and posts lots of info that either directly or indirectly relates to the interest of androgens - Bravo! While it is not for me state his motives, if he had to break every article that he posts down, it can't be done without losing some valuable info. So the reader needs to step up if he is that interested in the topic.

I recommend that all learn to read this stuff. It will help to balance out 'bro-science' (which is a collection of good learned info mixed with myth and falsehood - just as old-wive's-tales).

The 'scary' thing about learning to read this stuff is when you begin to see the authors bias and unsubstantiated statements. That is NOT how science is supposed to be. But it is the nature of humans to be opinionated and to suck-up to others.
 
García-Hermoso A, Cavero-Redondo I, Ramírez-Vélez R, et al. Muscular strength as a predictor of all-cause mortality in apparently healthy population: a systematic review and meta-analysis of data from approximately 2 million men and women. Archives of Physical Medicine and Rehabilitation 2018. http://www.sciencedirect.com/science/article/pii/S0003999318300790

Objective The aim of the present systematic review and meta-analysis was to determine the relationship between muscular strength and all-cause mortality risk and to examine the sex-specific impact of muscular strength on all-cause mortality in apparently healthy population.

Data Sources Two authors systematically searched MEDLINE, EMBASE and SPORTDiscus databases and conducted manual searching of reference lists of selected articles. Study Selection Eligible cohort studies were those that examined the association of muscular strength with all-cause mortality in apparently healthy population. The hazard ratio (HR) estimates with 95% confidence interval (CI) were pooled by using random effects meta-analysis models after assessing heterogeneity across studies.

Data extraction Two authors independently extracted data.

Data Synthesis Thirty-eight studies with 1,907,580 participants were included in the meta-analysis. The included studies had a total of 63,087 deaths. Higher levels of handgrip strength were associated with a reduced risk of all-cause mortality (HR= 0.69; 95% CI, 0.64–0.74) compared to lower muscular strength, with a slightly stronger association in women (HR= 0.60; 95% CI, 0.51–0.69) than men (HR= 0.69; 95% CI, 0.62–0.77) (all p<0.001). Also, adults with higher levels of muscular strength, as assessed by knee extension strength test, had a 14% lower risk of death (HR= 0.86: 95% CI, 0.80–0.93; p < 0.001) compared to adults with lower muscular strength.

Conclusions Higher levels of upper- and lower-body muscular strength are associated with a lower risk of mortality in adult population, regardless of the age and follow-up period. Muscular strength tests can be easily performed to identify people with a lower muscular strength and, consequently, with an increased risk of mortality.

I totally agree . My years of weightlifting and heavy lifting jobs has kept me in top shape . Its in my DNA , my grandfather was a concrete finisher and bull-strong . At 58 I still out-lift and outwork my much younger peers. No one on my jobs can keep up with me . I take great pride in this....Never stop !! :mad: ~Ogh
 
Well than shouldn't Brian Shaw live to 300 years old than. In reality is strength really a good indicator of longevity and overall health? To me it is not.
 
I don't understand any of your posts, I imagine they're useless entirely to most members and although the content could be very interesting or helpful, you post in a way as if you where talking with a forum of Medical doctors and we're not. I have a 4 year degree from a university, but your posts are still way over my head, 9 times out of ten.
How is this possible?!?!!
 
How is this possible?!?!!

As the moderator and creator of mesorx, (a forum that by the way, I thoroughly enjoy) I'm sure you must have noticed that the "doctors" posts are seldomly responded too. This is probably because like myself and alot of other members, the post the "doctor" makes are over most of are heads and just not helpful to the average bodybuilder without a previous education in the field of medicine or the knowelge of medical terminology.

This is my opinion, and I'm entitled to it. I did not disrespect doc scally until he disrespected me, I had no intention of disrespecting you either @Millard Baker
So please do not take any offense.

Have a good day.
 
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As the moderator and creator of mesorx, I'm sure you must have noticed that the "doctors" posts are seldomly responded too. This is probably because like myself and alot of other members, the post the "doctor" makes are over most of are heads and just not helpful to the average bodybuilder without a previous education or knowelgde of medical terminology.
Quite honestly, I haven't seen anyone do more for the average bodybuilder by scouring the medical literature on a daily basis to locate evidence-based research and expert analysis/commentary relevant to anabolic steroid users.

If bodybuilders want to know the answer to questions like 'how do steroids affect the cardiovascular system?' then @Michael Scally MD has answered them better than anyone else i.e. Anabolic Steroids and Cardiovascular Function

Dr. Scally has done all the leg work to help us navigate the literature to find the answers. This is invaluable to anyone who likes to think for themselves.
 
Quite honestly, I haven't seen anyone do more for the average bodybuilder by scouring the medical literature on a daily basis to locate evidence-based research and expert analysis/commentary relevant to anabolic steroid users.

If bodybuilders want to know the answer to questions like 'how do steroids affect the cardiovascular system?' then @Michael Scally MD has answered them better than anyone else i.e. Anabolic Steroids and Cardiovascular Function

Dr. Scally has done all the leg work to help us navigate the literature to find the answers. This is invaluable to anyone who likes to think for themselves.

I agree the guy has clearly made a ton of contributions to this forum, but would it kill him to dumb it down a little bit for me? Lol
 
Sitting-Rising Test (SRT) (English subtitles) Nov 2011


Sitting-Rising Test (SRT) partial scores began with a maximum of 5 points, separately for sitting and rising. In other words, the maximal/best score is 10. The two basic movements in the SRT — lowering to the floor and standing back up — are each scored on a 1-to-5 scale.

One point was subtracted for each support utilized, that is, hand, forearm, knee, or side of leg, and an additional 0.5 point was subtracted if the evaluator perceived an unsteady execution (partial loss of balance) occurring during the action. In addition, one point was subtracted if the subject placed one hand on the knee in order to sit or rise.

Crossing the legs for either sitting or rising from the floor was allowed, while the sides of the subject’s feet were not used for support.

Participants who scored fewer than eight points on the test were twice as likely to die within the next six years compared with those who scored higher; those who scored three or fewer points were more than five times as likely to die within the same period compared with those who scored more than eight points.

de Brito LBB, Ricardo DR, de Araujo DSMS, Ramos PnS, Myers J, de Araujo CGS. Ability to sit and rise from the floor as a predictor of all-cause mortality. European Journal of Preventive Cardiology. http://geriatrictoolkit.missouri.edu/srff/deBrito-Floor-Rise-Mortality-2012..pdf
 
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