Yes let’s research that!
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I wonder if ur hypoglycemic (reactive for me) if gh would really screw me up? Regular glucose tests thru finger prick are not reliable for me, last bw my glucose was 41 waaay to low abd that was after eating because i hate going fasted for bw, i feel like dog crap, when i got my results i went home and check w a finger prick and it was 88 but i felt like dog crap, so i took a half tab of glucose (,from walgreens) and about 30 min later felt awesome,
So i wonder how gh would effect me and if ud actually start feeling better?
If u go hypo at night ur fucked tho bro, i know some who do it before bed, but i do wonder if u go hyper at night if it would wake u, so u could down a mountain dew or oj, or if it would cause issues that may eventually really effect u?
I found this study:
Evening versus morning injections of growth hormone (GH) in GH-deficient patients: effects on 24-hour patterns of circulating hormones and metabolites.
Randomized controlled trial
Jørgensen JO, et al. J Clin Endocrinol Metab. 1990.
Show full citation
Abstract
Since serum GH in normal subjects displays a circadian variation with a major and consistent surge after the onset of sleep we examined whether the time of GH administration in GH-deficient patients had any impact on its action. Eight GH-deficient patients all underwent 3 4-week study schedules in random order: 1) evening (2000 h) sc GH injections, 2) morning (0800 h) sc GH injections, and 3) no GH administration. At the end of each period the patients were admitted to hospital for 24-h measurements of hormones and metabolites. For comparison, 10 age- and sex-matched healthy untreated subjects were hospitalized once under identical conditions. Mean (+/- SE) GH availability, i.e. the area under the curve (AUC; micrograms per L/12 h) for 12 h after injection was significantly greater after evening injection than after morning injections [83.3 +/- 25.4 (evening) vs. 46.0 +/- 10.6 (morning); P less than 0.01]. This might be due to higher skin and sc temperatures when in bed. The 2000-0800 h AUC after evening injection was similar to the corresponding AUC in the reference group. Mean 24-h serum insulin-like growth factor-I levels (micrograms per L) were similar after evening (189.8 +/- 2) and morning (179.5 +/- 5.3) injections (P = 0.8), but the latter displayed a circadian variation suggesting that a steady state had not been reached. Both were significantly lower than the stable reference value (248.4 +/- 3.6 micrograms/L). Blood glucose profiles after morning and evening GH did not differ from that of the reference group, whereas blood glucose decreased when the patients received no GH (P less than 0.01). Daytime (0800-2400 h) insulin levels were increased after morning injections (P less than 0.05). Nighttime levels of lipid intermediates were below normal in the untreated state and after morning injection (P less than 0.05), whereas nighttime blood alanine tended to be above normal after morning GH injection (P = 0.08). Highly significant inverse relationships between circadian lipid intermediates and both blood alanine and lactate concentrations were observed in the reference group and in the patients after evening injections. These relationships disappeared after morning injections. We conclude that the metabolic effects of sc GH injections are clearly influenced by the time of administration and that the closest similarity to normal hormone and metabolite patterns and relationships is reached by GH injection in the evening in GH-deficient patients.
Evening versus morning injections of growth hormone (GH) in GH-deficient patients: effects on 24-hour patterns of circulating hormones and metabolites.
Randomized controlled trial
Jørgensen JO, et al. J Clin Endocrinol Metab. 1990.
Show full citation
Abstract
Since serum GH in normal subjects displays a circadian variation with a major and consistent surge after the onset of sleep we examined whether the time of GH administration in GH-deficient patients had any impact on its action. Eight GH-deficient patients all underwent 3 4-week study schedules in random order: 1) evening (2000 h) sc GH injections, 2) morning (0800 h) sc GH injections, and 3) no GH administration. At the end of each period the patients were admitted to hospital for 24-h measurements of hormones and metabolites. For comparison, 10 age- and sex-matched healthy untreated subjects were hospitalized once under identical conditions. Mean (+/- SE) GH availability, i.e. the area under the curve (AUC; micrograms per L/12 h) for 12 h after injection was significantly greater after evening injection than after morning injections [83.3 +/- 25.4 (evening) vs. 46.0 +/- 10.6 (morning); P less than 0.01]. This might be due to higher skin and sc temperatures when in bed. The 2000-0800 h AUC after evening injection was similar to the corresponding AUC in the reference group. Mean 24-h serum insulin-like growth factor-I levels (micrograms per L) were similar after evening (189.8 +/- 2) and morning (179.5 +/- 5.3) injections (P = 0.8), but the latter displayed a circadian variation suggesting that a steady state had not been reached. Both were significantly lower than the stable reference value (248.4 +/- 3.6 micrograms/L). Blood glucose profiles after morning and evening GH did not differ from that of the reference group, whereas blood glucose decreased when the patients received no GH (P less than 0.01). Daytime (0800-2400 h) insulin levels were increased after morning injections (P less than 0.05). Nighttime levels of lipid intermediates were below normal in the untreated state and after morning injection (P less than 0.05), whereas nighttime blood alanine tended to be above normal after morning GH injection (P = 0.08). Highly significant inverse relationships between circadian lipid intermediates and both blood alanine and lactate concentrations were observed in the reference group and in the patients after evening injections. These relationships disappeared after morning injections. We conclude that the metabolic effects of sc GH injections are clearly influenced by the time of administration and that the closest similarity to normal hormone and metabolite patterns and relationships is reached by GH injection in the evening in GH-deficient patients.
But the title is geared toward gh deficient patients.... Not guys like us who (and gals) want to use it to increase fat loss or for other reasons, their bodies are not making it like us, sooo it might just effect us differently as our parts are working to make the gh we already need
Metabolic effects of growth hormone administered subcutaneously once or twice daily to growth hormone deficient adults.
Randomized controlled trial
Laursen T, et al. Clin Endocrinol (Oxf). 1994.
Show full citation
Abstract
OBJECTIVE: The aim of this study was to compare the metabolic effects of GH administered subcutaneously either once or twice daily. The actions of GH might depend upon a pulsatile pattern of serum GH. Pulsatile and continuous intravenous delivery of GH, however, induce similar short-term metabolic effects in GH deficient patients. An improved growth response is obtained in GH deficient children when a fixed weekly GH dose is administered by daily subcutaneous injections instead of twice or thrice-weekly intramuscular injections. A more pulsatile pattern and serum GH levels above zero might be achieved by further increasing the injection frequency. Increased daytime GH levels might, however, adversely affect the circadian patterns of metabolic indices, which have been demonstrated to be more successfully reproduced by evening compared with morning GH administration.
DESIGN AND MEASUREMENTS: In a cross-over study, 8 GH deficient patients (age 16-43 years) were treated with 3 IU/m2/24 h of human GH. The dose was injected in the evening for 4 weeks and for another 4 weeks two-thirds was injected in the evening and one-third in the morning. At the end of each period the patients were admitted to the hospital for 37 hours. Steady-state profiles of GH, IGF-I, IGF binding proteins 1 and 3, insulin, glucose, lipid intermediates and metabolites were obtained following administration of 3 IU/m2 of GH (at 1900 h (one injection) and at 1900 and 0800 h (two injections)).
RESULTS: Similar mean integrated levels of serum GH (mU/l) were obtained (7.46 +/- 0.84 (one injection) vs 6.46 +/- 0.62 (two injections) (P = 0.15)). Mean levels +/- SEM of serum IGF-I (micrograms/l) were significantly increased (P < 0.01) following two daily GH injections (330.3 +/- 48.1 (one injection) vs 399.1 +/- 53.0 (two injections)). Serum IGFBP-3 levels were not significantly different on the two occasions, while levels of the GH independent IGFBP-1 (micrograms/l) were slightly but significantly lower following twice-daily GH injections (1.61 +/- 0.42 vs 1.13 +/- 0.56, respectively (P < 0.04)). The pattern of IGFBP-1 was opposite to that of insulin. Similar levels of insulin and glucose were obtained with both GH regimens, while levels of non-esterified fatty acids were significantly higher following once-daily GH injection (P < 0.001).
CONCLUSIONS: Twice-daily GH injections, apart from producing a more physiological serum GH profile, were superior to one injection in increasing serum IGF-I and decreasing IGFBP-1 levels. Both of these changes tend to amplify the effects of the administered GH. Twice-daily injections, however, resulted in lower night-time levels of lipid intermediates.
Randomized controlled trial
Laursen T, et al. Clin Endocrinol (Oxf). 1994.
Show full citation
Abstract
OBJECTIVE: The aim of this study was to compare the metabolic effects of GH administered subcutaneously either once or twice daily. The actions of GH might depend upon a pulsatile pattern of serum GH. Pulsatile and continuous intravenous delivery of GH, however, induce similar short-term metabolic effects in GH deficient patients. An improved growth response is obtained in GH deficient children when a fixed weekly GH dose is administered by daily subcutaneous injections instead of twice or thrice-weekly intramuscular injections. A more pulsatile pattern and serum GH levels above zero might be achieved by further increasing the injection frequency. Increased daytime GH levels might, however, adversely affect the circadian patterns of metabolic indices, which have been demonstrated to be more successfully reproduced by evening compared with morning GH administration.
DESIGN AND MEASUREMENTS: In a cross-over study, 8 GH deficient patients (age 16-43 years) were treated with 3 IU/m2/24 h of human GH. The dose was injected in the evening for 4 weeks and for another 4 weeks two-thirds was injected in the evening and one-third in the morning. At the end of each period the patients were admitted to the hospital for 37 hours. Steady-state profiles of GH, IGF-I, IGF binding proteins 1 and 3, insulin, glucose, lipid intermediates and metabolites were obtained following administration of 3 IU/m2 of GH (at 1900 h (one injection) and at 1900 and 0800 h (two injections)).
RESULTS: Similar mean integrated levels of serum GH (mU/l) were obtained (7.46 +/- 0.84 (one injection) vs 6.46 +/- 0.62 (two injections) (P = 0.15)). Mean levels +/- SEM of serum IGF-I (micrograms/l) were significantly increased (P < 0.01) following two daily GH injections (330.3 +/- 48.1 (one injection) vs 399.1 +/- 53.0 (two injections)). Serum IGFBP-3 levels were not significantly different on the two occasions, while levels of the GH independent IGFBP-1 (micrograms/l) were slightly but significantly lower following twice-daily GH injections (1.61 +/- 0.42 vs 1.13 +/- 0.56, respectively (P < 0.04)). The pattern of IGFBP-1 was opposite to that of insulin. Similar levels of insulin and glucose were obtained with both GH regimens, while levels of non-esterified fatty acids were significantly higher following once-daily GH injection (P < 0.001).
CONCLUSIONS: Twice-daily GH injections, apart from producing a more physiological serum GH profile, were superior to one injection in increasing serum IGF-I and decreasing IGFBP-1 levels. Both of these changes tend to amplify the effects of the administered GH. Twice-daily injections, however, resulted in lower night-time levels of lipid intermediates.
True. What makes a person gh deficient?
Kingsbergmedical:
Is There a Best Time Of Day To Take Growth Hormone Injections?
Growth hormone therapy is the safest and most effective way to treat men or women suffering from a growth hormone deficiency. The only way to take authentic growth hormone is via injections. Many patients who have been prescribed HGH therapy wonder if there is a best time to take their growth hormone injections.
Since your natural HGH levels fluctuate throughout the day, for the most part, it does not really matter when you take your growth hormone injection. However, depending on your given prescription for growth hormone, your age, and lifestyle, there could be one time of day that is better than another for your growth hormone injections.
Depending on your given prescription for growth hormone, your age, and lifestyle, there could be one time of day that is better than another for your growth hormone injections.
Should I Take Growth Hormone Injections at Night, or In the Morning?
For a lot of growth hormone therapy patients, doctors will simply recommend you take your HGH injections, at night just before bed. This way it becomes part of your night time routine, and you are not under pressure to do it in the morning when you may be rushing to get to work, or have your mind on other things.
However, that may not always be the case. Here are some other things to consider, when you are thinking about the best time to administer growth hormone injections.
If you are splitting your dose two times a day, it is recommended that you do one HGH injection in the morning and one in the late afternoon. This is because your natural release of cortisol is highest in the early morning and late afternoon, and HGH injections can counteract the metabolism slowing and emotionally draining effects of cortisol.
For a lot of growth hormone therapy patients, doctors will simply recommend you take your HGH injections, at night just before bed. This way it becomes part of your night time routine.
Is It Any Safer To Take HGH Injections at Night or During the Day?
When given properly, growth hormone injections have been clinically proven to be the safest and most effective way to treat growth hormone deficiency (GHD). There is no greater risk of side-effects created by the time of day you choose to take your HGH injections.
Thank you. I knew this. Wasn’t thinking.
So this explains why some take one upon waking, wait to eat, and or do fasted cardio, and then post workout take the next injection..... Hmmm me thinks it makes too much sense hahaha,
Kingsbergmedical:
Is There a Best Time Of Day To Take Growth Hormone Injections?
Growth hormone therapy is the safest and most effective way to treat men or women suffering from a growth hormone deficiency. The only way to take authentic growth hormone is via injections. Many patients who have been prescribed HGH therapy wonder if there is a best time to take their growth hormone injections.
Since your natural HGH levels fluctuate throughout the day, for the most part, it does not really matter when you take your growth hormone injection. However, depending on your given prescription for growth hormone, your age, and lifestyle, there could be one time of day that is better than another for your growth hormone injections.
Depending on your given prescription for growth hormone, your age, and lifestyle, there could be one time of day that is better than another for your growth hormone injections.
Should I Take Growth Hormone Injections at Night, or In the Morning?
For a lot of growth hormone therapy patients, doctors will simply recommend you take your HGH injections, at night just before bed. This way it becomes part of your night time routine, and you are not under pressure to do it in the morning when you may be rushing to get to work, or have your mind on other things.
However, that may not always be the case. Here are some other things to consider, when you are thinking about the best time to administer growth hormone injections.
If you are splitting your dose two times a day, it is recommended that you do one HGH injection in the morning and one in the late afternoon. This is because your natural release of cortisol is highest in the early morning and late afternoon, and HGH injections can counteract the metabolism slowing and emotionally draining effects of cortisol.
For a lot of growth hormone therapy patients, doctors will simply recommend you take your HGH injections, at night just before bed. This way it becomes part of your night time routine.
Is It Any Safer To Take HGH Injections at Night or During the Day?
When given properly, growth hormone injections have been clinically proven to be the safest and most effective way to treat growth hormone deficiency (GHD). There is no greater risk of side-effects created by the time of day you choose to take your HGH injections.
Livestrong:
Why Do HGH Secretions Increase When Fasting?
LEXA W. Lee
Human growth hormone, or somatotropin, increases when you fast. Under normal circumstances, HGH promotes the synthesis of lean muscle and the storage of glycogen as well as fat. However, when you fast, increased levels of the hormone stimulate the breakdown of fatty tissue, according to Niels Moller of Aarhus University Hospital in Denmark. Your body needs the fat to produce energy,
How it Works
The increase in HGH during fasting helps to preserve your muscle tissue and glycogen stores while using your fat stores instead. This breakdown of fat, which is called lipolysis, releases free fatty acids and glycerol, which are then metabolized to produce energy. According to Madelon Buijs, researcher at Leiden University Medical Center in the Netherlands, levels of HGH, which is produced by the pituitary gland, rise noticeably within 13 hours after starting a fast.
Blood Levels
In cases of a lack of HGH during fasting, protein loss from muscle increases by about 50 percent. In addition to fasting, exercise and stress can also increase HGH levels. They are also subject to much variation during the day, because your pituitary gland releases the hormone in bursts. Random measurement of HGH, as opposed to monitoring it over a period, is not very useful. Moreover, levels in the morning will be higher, according to LabTestsOnline.org.
Obesity
In nonfasting individuals, insulin regulates glucose metabolism for energy, but during periods of fasting, HGH becomes predominant. However, lipolysis may be blunted in obese individuals during periods of fasting due to different factors, one of which may be their lower levels of HGH. This effect may cause obese individuals to retain adipose tissue. However, the lower HGH may also protect them against the effects of excessively high levels of free fatty acids, which can be toxic to cells.
Why Do HGH Secretions Increase When Fasting?
LEXA W. Lee
Human growth hormone, or somatotropin, increases when you fast. Under normal circumstances, HGH promotes the synthesis of lean muscle and the storage of glycogen as well as fat. However, when you fast, increased levels of the hormone stimulate the breakdown of fatty tissue, according to Niels Moller of Aarhus University Hospital in Denmark. Your body needs the fat to produce energy,
How it Works
The increase in HGH during fasting helps to preserve your muscle tissue and glycogen stores while using your fat stores instead. This breakdown of fat, which is called lipolysis, releases free fatty acids and glycerol, which are then metabolized to produce energy. According to Madelon Buijs, researcher at Leiden University Medical Center in the Netherlands, levels of HGH, which is produced by the pituitary gland, rise noticeably within 13 hours after starting a fast.
Blood Levels
In cases of a lack of HGH during fasting, protein loss from muscle increases by about 50 percent. In addition to fasting, exercise and stress can also increase HGH levels. They are also subject to much variation during the day, because your pituitary gland releases the hormone in bursts. Random measurement of HGH, as opposed to monitoring it over a period, is not very useful. Moreover, levels in the morning will be higher, according to LabTestsOnline.org.
Obesity
In nonfasting individuals, insulin regulates glucose metabolism for energy, but during periods of fasting, HGH becomes predominant. However, lipolysis may be blunted in obese individuals during periods of fasting due to different factors, one of which may be their lower levels of HGH. This effect may cause obese individuals to retain adipose tissue. However, the lower HGH may also protect them against the effects of excessively high levels of free fatty acids, which can be toxic to cells.
T&H
Well-known Member
Go hypo??? Doesn't every article posted say hgh increase blood sugar and not lower it? The article Kim posted above said you could inject at night if you eat earlier before bed. I'll reiterate that it said best time was when fasting, whether morning or night. I always inject when fasting and never showed hypo signs, ever.
So I am hypo, but trying different combinations of t4/t3. Hoping this will help.
My hypo isn’t from the hgh though. Wanted to make sure people didn’t misread it.
They found a tumor in my pituitary. I feel tired a lot. I know the total crap feeling. What is your eating plan?
Thats good, i can go hypo due to being reactive hypoglycemic, so it concerns me especially if they are new to gh ( like myself, not saying u) and everyone reacts differently wether fasted or not
Damn sorry to hear that
I eat crappy sometimes, but overall been trying to eat as my trainer has set out my diet.....
My doc on the other hand wants me to cut eggs out and add oatmeal erry morning due to cholesterol.... but my trainer doesnt like oat meal, and usually a few chicken and or turkey samiches daily w protein powder and veggies n either red meat at night or chicken breasts
I usually inject 30 mins after eating oatmeal before bed. So far, so good.
I really hope it helps you too!
I want to make sure people are on the same page. Do you mean hypo(glycemic) or hypo(thyroid)? I think the posts above yours were referring to hypoglycemia.
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