Pale no more -- Tanning peptide melanotan

[solo47]

Shocked & Dismayed

Gee, what a terrible to shock to my trust in humanity: Kakarot was fucking advertising all this time! Golly, what next? As I said, what a stinking pile of fucking crap, on an AAS forum too. Some of these giantass muscle kings that post on here should find your office & kick your brown fucking ass.

 

[brbb]

solo, ive gotta admit, iam usually a sceptic on this sort of stuff too. However, ive heard about how australia is 'pioneering research' into sunless tanning. I think kakrot mentioned it - we've got the highest incidence of skin cancer in the world and its a huge burden on the health system (which, unlike in america, is still largely funded by the government). Needless to say, heaps of money is being pumped into this new technology by the government and by the private sector.

What i am surprised about is the lack of exposure that this new product has gained.

Seriously kakarot, how could i have not heard about this yet? Every night on the news there is some political figure denouncing the use of solariums as 'the cancer of this great nation'. If, as you purport, this stuff is working, people would know about it and it would be all over the news.

That said, im pretty intrigued. What state is your brother in? What does the gear cost? ... and will my purple bell-end turn black?

 

[Kakarot]

LOL, no your purple bell end will not turn black. Neither will your hair nor eye color. MT-2 only effects the skin. If people want price info they should email me b.c we are not supposed to discuss price on the forum for whatever reason.

Epitan (the pharmaceutical company who holds the patent) is not releasing it commercially until late 2007-early2008 -- so you media saturation will occur just prior to this time. However, the idea that it has not been in the news at all is incorrect. Just google Melanotan and you will see how many news articles have been written on this peptide thus far.

I believe I have already posted some scientific abstracts on this thread about MT-2, but if there's any suspician as to the potency of MT-2, I will post some more abstracts; and you can always go to any biomedical scientific database online and search for abstracts and assays on MT-2. Over 100 scientific papers have been written on Melanotan so far. There is no shortage of evidence as to the effectiveness of MT-2. That is unequivocal.

 

[Kakarot]

Actually I guess I am allowed to mention my price -- $80 per 10 mg at the moment.

Comes with full Mass Spectometry and High Pressure Liquid Chromatography documentation direct from synthesizer which corroborates the peptide as >98% pure.

 

[Kakarot]

I am more than happy to share all sources I am currently aware of selling MT-2 if people are interested. B.C I'm involved in the research of proteomics, I have unrestricted access to these substances, hence I can supply.

As to the validity of MT-2, I will now post several of the over 100 scientific papers that have been written on this peptide from universities all over the world. There is nothing phony about MT-2. It is state of the art biotech.

 

[Kakarot]

APHRODISIAC PROPERTIES OF MT-2

Here is the link if anyone wants to read the full scientific assay:

http://www.ncbi.nlm.nih.gov/entrez/...d&dopt=Abstract&list_uids=15996790&query_hl=1

And here's the abstract:


Peptides. 2005 Oct;26(10):1687-9. Related Articles, Links

Discovery that a melanocortin regulates sexual functions in male and female humans.
Hadley ME.

Department of Cell Biology & Anatomy, University of Arizona, College of Medicine, Tucson, AZ 85724-5044, USA. erectide@aol.com

Melanocortins (MCs) are multifunctional peptide hormones that regulate a diversity of physiological functions. MCs have been implicated in sexual function in animals. We document here that a MC analog, Melanotan II (MTII), can enhance sexual function in human males (erectile activity) and females (increased levels of sexual desire and genital arousal). Unlike other sexual-enhancement drugs, MTII works at the level of the brain, thus eliciting a rather natural sexual response with minimal or no undesirable side effects. The actions of the peptide were discovered accidentally while studying the effects of the peptide and related analogs on human skin pigmentation (tanning).

PMID: 15996790 [PubMed - in process]

 

[Kakarot]

NOTA BENE: all articles were taken from PubMed, one of the largest, most esteemed biotech, molecular biology, and genomics databases in the world.

All abstracts can be viewed in original form at PubMed or ANY other scientific database, or go to your public library and peruse the backlog of scientific journals in print, and you will find a plethora of recent journals on Melanotan.

 

[Kakarot]

Here's the third abstract I've now posted on Melanotan's tanning ability.

The link is: http://www.ncbi.nlm.nih.gov/entrez/...ed&dopt=Abstract&list_uids=9113347&query_hl=3


Biopharm Drug Dispos. 1997 Apr;18(3):259-69. Related Articles, Links
Click here to read
Skin pigmentation and pharmacokinetics of melanotan-I in humans.

Ugwu SO, Blanchard J, Dorr RT, Levine N, Brooks C, Hadley ME, Aickin M, Hruby VJ.

Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona 85721, USA.

A comparative pharmacokinetic trial was performed with a superpotent synthetic melanotropic peptide, [Nle4-D-Phe7]-alpha-MSHi-13 (melanotan-I or MT-I) given by three routes of administration. Plasma levels were measured by RIA and tanning was quantiated using serial reflectometry. Doses of 0.16 mgkg-1 were administered intravenously (IV) and orally (PO), and doses from 0.08 to 0.21 mg kg-1 subcutaneously (SC), in a randomized crossover fashion to three male volunteers over five consecutive days for 2 weeks (ten doses). The results indicate that the SC dose is completely bioavailable compared to the IV dose. No detectable drug levels were observed following PO dosing. The plasma half-lives following SC dosing ranged from 0.07 to 0.79 h for the absorption phase and from 0.8 to 1.7 h for the beta-phase. Clearance ranged from 0.12 to 0.19 L kg-1 h-1 and 3.9% or less of the dose was recovered in the urine. Side-effects were minimal, consisting of occasional gastrointestinal upset and facial flushing. Significant tanning of the forehead, arms, and neck was noted following IV or SC dosing. This effect peaked at 1 week following drug administration but was still present 3 weeks after completing the ten-dose regimen. It is concluded that SC administration is an efficacious method of delivering melanotan-I.

 

[Kakarot]

And here's the 5th abstract on MT-2's tanning ability:

First, the link: http://www.ncbi.nlm.nih.gov/entrez/...ed&dopt=Abstract&list_uids=8637402&query_hl=3


Life Sci. 1996;58(20):1777-84. Related Articles, Links
Click here to read
Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study.

Dorr RT, Lines R, Levine N, Brooks C, Xiang L, Hruby VJ, Hadley ME.

College of Medicine, Pharmacology Department, University of Arizona, Tucson, USA.

A pilot phase I study was conducted with a cyclic heptapeptide analog of alpha-melanocyte stimulating hormone (alpha-MSH). The lactam-bridged molecule, called Melanotan-II (MT-II), has the structure Ac-Nle4-Asp5-His6-D-Phe7-Arg8-Trp9-Lys10 alpha-MSH4-10-NH2 (MT-II) and has superpotent melanotropic activity in vitro. A single-blind, alternating day (saline or MT-II), placebo-controlled trial was conducted in 3 normal male volunteers at the starting dose of 0.01 mg/kg of MT-II. Subcutaneous injections of MT-II or saline were given daily (Monday-Friday) for 2 consecutive weeks. Two subjects were escalated by 0.005 mg/kg increments to 0.03 mg/kg and one to 0.025 mg/kg. The 0.03 mg/kg dose produced Grade II somnolence and fatigue in one of two subjects (WHO standards). Mild nausea, not requiring antiemetic treatment, was reported at most MT-II dose levels. A stretching and yawning complex appeared to correlate with the onset of spontaneous, penile erections which were intermittently experienced for 1-5 hours after MT-II dosing, depending on the MT-II dose. Two subjects had increased pigmentation in the face, upper body and buttock, as measured by quantitative reflectance and by visual perception 1 week after MT-II dosing ended. These results demonstrate that MT-II has tanning activity in humans given only 5 low doses every other day by subcutaneous injection. The recommended single MT-II dose for future Phase I studies is 0.025 mg/kg/day.

Publication Types:

* Clinical Trial
* Clinical Trial, Phase I
* Controlled Clinical Trial


PMID: 8637402 [PubMed - indexed for MEDLINE]

 

[Kakarot]

Here is another abstract showing powerful aphrodisiac effect of MT-II (Nota bene: as the previous abstract regarding MT-2 as an aphrodisiac attests, the aphrodisiac effects of MT-II are seen in both males and females because it acts direct on hypothalamus instead of merely being a localized vasodilator like Viagra -- this is why MT-II is much more potent in this regard.



[Therapy of erectile dysfunction in 2005]
[Article in German]

Porst H.

Hamburg. Porst20354@aol.com

Erectile dysfunction (ED) management in the following 3-5 years will be dominated by substances targeting the L-arginine-NO-guanylate cyclase-cGMP-PDE-5 pathway, resulting in an intracellular elevation of the cGMP concentrations. Promising alternatives to the PDE-5 inhibitors, such as guanylate cyclase activators and Rho-kinase inhibitors, may also effectively compliment a PDE-5 inhibitor. Intranasal application of the melanocortin agonist PT 141 (Melanotan II) seems to be promising. As scheduled sexual activities are not preferred by the majority of couples, the future of ED-therapy will focus on drugs with a 1-2 day long efficacy window, or a daily bedtime application of low dosage agents which result in nocturnal reoxygenation of the cavernous bodies and in turn in functional improvement. Elevation of the cGMP levels and improvement of endothelial function as a result of this approach also promises benefits in cardiovascular diseases and in LUTS.

PMID: 14569381 [PubMed - indexed for MEDLINE]

 

[Kakarot]

For anyone who possibly still thinks this drug is not legit, EPITAN, the pharmaceutical company who holds the patent on this drug and have invested tens of millions of R&D into it, are on stock exchanges. You can buy stock. Go to their website. Just google their name. They're a large corporate pharmacy in Australia.

Google Melanotan. There are dozens of news articles that have been written on Melanotan available online, perhaps many, many more.

 

[Kakarot]

To post in response to repeated emails so all can see, I cannot go below 80 USD per 10 mg right now of MT-2. Sorry. Yes, it's still pricey, but it's a very very good price for MT-2.

 

[Toast]

How long does the tan last once the cycyle ends? How soon can your start another one?

 

[Kakarot]

the tan lasts as long as a normal tan would last because that's exactly what it is. So 2-4 weeks. I've gone over a month w/o dosing and lost very little color.

You can start a cycle again whenever you want. MT-2 has been proven in a myriad of studies to be nontoxic unless taken in enormous quantities (100 grams) in a short timeframe, so you can use year round. Or just occasionally, just enough to maintain a light tan.

 

[Kakarot]

No, LifeSource is definitely a hugely inflated source for MT-2. They are drastically overcharging customers if they're charging 250 per 10 mg.

 

[Kakarot]

USING & STORING MT-2:

Here's some info on using MT-2:

For example, if you order 30 mg (which is a sufficient amount for a first-time beginner cycle) You will receive your 30 mg of "lyophilized" (it means "freeze-dried") MT-2 through fed-ex with cold packs.

Put two vials in the freezer (deep freeze if you have one) -- DO NOT RECONSTITUTE (reconstitute just means "mix" with bacteriostatic water) these vials. Just freeze them as is.

Then with the vial you are going to be using, reconstitute (mix with bacteriostatic water).

NOTE: Bacteriostatic water is just purified water with an antimicrobial agent you can OTC at any pharmacy -- very cheap (2-4 bucks for a year supply).

To mix the vial with bac water, take one of the your syringes (BD Ultrafine II 1cc or 1/3 cc are excellent and I recommend them) and take your bacteriostatic water. If using a 1 cc syringe (100 units) use the syringe to withdraw 1 full and one half-full syringe-loads (150 cc altogether) and inject that into the vial of MT-2 through the rubber, resealable tamper proof lid.

So now you have 150 units (1.5 cc) of bacteriostatic water mixed with 10 mg of MT-2 in your vial.

Shake the vial for at least 2 minutes to thoroughly mix and let the peptide defrost -- (normally we use a process called sonification which is more efficient for this, but you need special equipment -- shaking will work fine, just do a VERY thorough job for the first time).

Then inject roughly 60 units (.6 cc) of air into the vial so that the vial is not a vacuum -- otherwise withdrawing peptide will be tricky because of suction in the vial. Don't inject too much air into the vial, otherwise the air pressure will push too much air back into the syringe when you try to withdraw the peptide for injection. Around 60 units usually works fine -- the "units" I'm using as a ref. for injecting are on the side of the syringes (100 unit = one full syringe).

Now, that the vial is mixed (reconstituted), when you withdraw 15 units of the substance, that equals 1 mg of MT-2. So 30 units would equal 2 mg. You get the idea?

Now you're ready for subcutaneous injection. If you've never performed sub-q injection before, it's very simple, and done right, you literally don't feel anything. The needles used for sub-q injection are extremely small (8 mm) and you only go in 5 mm or so -- just into fatty tissue beneath skin. NOT intravenous or intramuscular which is a bit more complicated. I'll send you a PDF file if you like from the National Institute of Health (USA) detailing sub-q injection. there's pictures and everything. I assure you it's extremely easy. Certain diabetics perform sub-q injections with the same tiny needles you'll be using two-three times a day.

You can use the same syringe you used to add the bac water to the vial for your first injection. But never use the same syringe twice on yourself -- this is a universal rule no matter what you're injecting. Syringes and bacteriostatic water are extremely cheap and you can get them OTC at any pharmacy like London Drugs, Pharmasave, etc, and you do not need a presciption.

You will store the reconstituted (mixed) vial in your fridge -- NOT your freezer like the others.

I recommend 1 mg of MT-2 injected twice per day for the first week or so. One morning injection, one evening. Remember, you will experience some nausea most likely for the first 2-4 days. It's nothing to be alarmed about, it's perfectly normal. Your body is simply finding a new homeostasis as it acclimates to the peptide in your blood. Your body adjusts within 2-4 days at the latest and you will never have any nausea again -- unless you come off MT-2 for a long time (over 2 months) and then resume heavy dosing. So remember, the nausea is COMPLETELY normal and entirely goes away.

The harder and more frequent erections as a side effect however will persist for as long as you are taking MT-2. MT-2 is more powerful than viagra in this regard, and a few pharm companies are making an analogue version of MT-2 called PT-141 to treat ED in the future.

After a week of 2 mg per day dosing you can taper down to 1-1.5 mg once a day until desired shade of tan is achieved. From there, maintenance dosing is minimal. I usually just use 1 vial over 10 days and then take 2-3 weeks off completely, and then repeat. Others use 1-2 mg every 5-7 days -- but that is difficult when you're using 10 mg vials -- if you want to go this route I will instruct you on it -- the other dosing method is much much easier.

Remember, the lyophilized MT-2 (freeze dried) will last in your freezer for 1 year. But once mixed with bac water, the MT-2 will only last for about 10-11 days -- AND YOU MUST STORE THE RECONSTITUTED MT-2 in the REFRIGERATOR -- NOT freezer. Freezing and unfreezing the peptide repeatedly is very bad for it and degrades it rapidly. You want to keep the temperature stable.

 

[Kakarot]

I'm getting a lot of PMs. I'm alot easier to contact via email which I check far more frequently: Kakarot@hushmail.com or you can check out my merchant thread @ Outlawmuscle.com

 

[Kakarot]

And no, you do not need to sign for packages even though I ship express -- just lemme know and I can adjust waybill.

 

[Kakarot]

New deal. We have MT1 available from synthesizer for 60 USD per 10 mg.

MT2 remains 80 USD per mg.

DHL has inspected synthesizer and agreed to business contract for shipping to UK, USA, Australia, and most of EU, among other places.

This means that MT2 and MT1 are now legal to order for personal use and research purposes. We have lots of happy customers now, you can check out thread @ Outlawmuscle.com.

I'm certainly willing to provide a very large discount to any mods interested in order to corroborate peptide's efficacy for others on the board if there's any doubts. Both batches are MS's @ >98% purity, which is high as synthesized peptides get.

 

[mr.nitro]

so where are the before and after pics?

ive seen this for sale at muscle reasearch