peptide shelf life after reconstitution.

[Stealth500]

Trying to decide if buying higher mg peptides is the right choice.

perhaps someone can chime as to which of these statements is correct and which is false.

"The bacteria found in air will degrade a peptide, which is why reconstituting a peptide with sterile water only makes sense if you intend on using the whole content of the vial within a day or two.

After 2-3 days, enough bacteria will have entered the vial to start to degrade the peptide, and a few days later it will be virtually useless (even if it has been stored in a fridge).

Peptides reconstituted in BAC water, however, can last for up to 2 weeks before starting to degrade and lose potency. After 4 weeks, the peptide will be pretty much useless (assuming it has been stored in a fridge).

Biggest Mistake People Make​

This is important because a lot of people think their 10,000iu HCG vial (or any other peptide for that matter) will last them 10 weeks if they pin 500iu twice a week, when the reality is they will only be able to take advantage of roughly 40% of that vial before it degrades almost completely.

Take this into account when using peptides, or you will continue to pin for no reason at all, and you will stop seeing the benefits you were expecting."

this next response was generated by chat GPT

" Reconstituted peptides stored in the refrigerator can remain stable for several days to a few weeks, but their stability can vary based on factors like the peptide's nature and storage conditions. For longer-term storage, it's advisable to aliquot the peptide and store it at lower temperatures, which can extend the shelf life for several months to a year or more."

 

[Stealth500]

"Yes, repeatedly freezing and thawing a reconstituted peptide can degrade its potency. It is recommended to aliquot the peptide into smaller portions to avoid multiple freeze-thaw cycles."

seems ordering a peptide that won't be used within 2 weeks is wasteful.

what is the point in ordering say 50mg vials of tirz?

 

[Ghoul]

There are so many variables regarding peptide longevity the only real answer is " reconstitute properly, use pharma BAC and get the smallest vial that's practical so it spends as little time reconstituted as possible."

 

[Stealth500]

so ordering a peptide such as tirz for long term use it would be advisable to order both smaller and mid potency vials?

 

[Ghoul]

Peptide is as broad a category as food. Some will remain stable for months, reconstituted, others will be significantly degraded within weeks.

For Tirz, I would advise a vial you would use within 30 days of reconstitution. What weekly dose (s) are you planning to use?

 

[Stealth500]

starting dosage is 2.5 so i think ordering one kit at 10mg and another at 30mg for longer term use would be sufficient.

 

[Stealth500]

Tirz, I would advise a vial you would use within 30 days of reconstitution. What weekly dose (s) are you planning to use?

thanks man.

 

[jaxked]

Kind of shocked by these answers myself. Why are the companies selling these massive bottles of peps if they're only good for 30 days once mixed?

 

[flipup7]

Kind of shocked by these answers myself. Why are the companies selling these massive bottles of peps if they're only good for 30 days once mixed?

The reason companies are selling them is because people are buying them.

But to the point, there are so many variables. It may be fine for a few months or it may only last a day or two depending on the peptide, storage conditions, bac water used, etc.

The main concern for most things is rate of degradation, its not like a peptide that would be fine at 29 days would be useless at 31 days. For the most part they will just become less effective with more time.

 

[jaxked]

The reason companies are selling them is because people are buying them.

But to the point, there are so many variables. It may be fine for a few months or it may only past a day or two depending on the peptide, storage conditions, bac water used, etc.

The main concern for most things is rate of degradation, its not like a peptide that would be fine at 29 days and would useless at 31 days. For the most part they will just become less effective with more time.

Ok, but for GLP's such as tirzepatide, sema, reta etc. How fast would they degrade in bac water in the fridge? I came on here looking for this info as there's not even any information on the chemical websites ie. Sigma alrich.

Had jamo conducted testing?

These tirzepatide bottles are getting into the 60mg range and the semaglutide 30mg.

I can see using a 40iu bottle of gh in 4 days and that being fine but a 30mg bottle of semaglutide? That's 12 weeks at 2.5mg a week.

 

[zpped]

The peptide testing group has jano results showing reconned tirz in the fridge only degrading 0.3% over 90 days. (and ~2% when stored in a closet)

It doesn't degrade that quickly. (It also withstands freezing at least once really well)

 

[flipup7]

Novo makes most Ozempic pens to have 4 doses, so that would be at least 28 days assuming it was produced right before being delivered. Thats of course with optimal pharma conditions.

I've seen compounding pharmacies that send vials of Tirz with 4 doses also. Thats probably a lot closer to the conditions any of us would see.

So that would be in line with Ghoul's 30 day rule of thumb. Given that, you'd only really want a 60mg tirz vial if you were at the max 15mg weekly dose.

 

[Stealth500]

i went down the rabbit hole again reading for a while after making this thread. One possibly reasonable solution to prolonging peptide shelf life would be pens. but imo.. just use the smallest vials to ensure potency-if you have to reconstitute an new vial each day so be it.


" Reconstituting a peptide and injecting it into an insulin pen can help with the delivery and potentially extend the shelf life of the peptide, but there are several important factors to consider:

1. Air Exposure: Peptides can degrade when exposed to air, as oxygen can lead to oxidation. Using an insulin pen, which is designed to minimize air exposure, may help reduce this risk.
2. Storage Conditions: Insulin pens are typically designed to maintain a stable environment for the medication. However, the specific storage conditions (temperature, light exposure) for the peptide should be considered, as some peptides require refrigeration.
3. Compatibility: Not all peptides are compatible with insulin pens. It's crucial to ensure that the peptide can be safely stored and delivered using the pen's mechanism. Some peptides may require specific formulations or diluents.
4. Stability: The stability of the reconstituted peptide in the pen should be evaluated. Some peptides may have a limited shelf life even when stored properly, so it's essential to follow guidelines for the specific peptide.
5. Consultation with Professionals: It's always best to consult with a healthcare professional or a pharmacist who has experience with peptides to ensure that the method of storage and delivery is appropriate and safe.

In summary, while using an insulin pen may help reduce air exposure and potentially extend the shelf life of a reconstituted peptide, it is essential to consider the specific characteristics of the peptide and consult with a professional for the best practices."