Better results since it's systemic, reaching deeper than a topical can, and thus far, appear to be lasting effects
Earlier studies that used simple, subjective measures of improvement suggested the results were equal, but newer methods that can measure the remodeling of collagen show significant, durable differences.
It's very telling that in recent years a lot of staff members of dermatologist offices have gone onto low dose isotretinoin regimens.
And also there's the simplicity of a couple of gelcaps a week, that benefits skin everywhere on the body, vs a time consuming topical application.
Low-dose ISO is effective in remodeling the extracellular matrix (ECM). This study found that the increase of collagen occurs through the augmentation of both collagen I and collagen III fibers. With originality, it was possible to verify the durability of these fibers for at least 12 weeks...
pubmed.ncbi.nlm.nih.gov