Pramipexole for Libido

Yes. No issues there.

Other issues investigated:
Pituitary tumor - MRI reveals unremarkable pituitary.
Adrenal fatigue - Cortisol high in morning, DHEA-S too high (above range)... no fatigue... excess, if anything. (??)
Prolactin - normal
Iron, Magnesium - normal
Hemochromatosis - none, normal iron
Thyroid deficiency - 5+ TSH, but high-normal T4 and high-normal T3 = ??
Hashimotos - no thyroid antibodies present
Estrogen - without TRT: below mid-range; on TRT: midrange
SHBG - too low, and never rises despite high E2 or T (!)

Clomid stim. test 30mg ED for 5 days brought TT past 700 ng/dL. For real.

Psychoactive drugs failed: Prozac, Celexa, Wellbutrin, Luvox, Effexor, Lithium (!), Ativan, Abilify, Adderall

One of Prami's main functions is to lower prolactin. If yours was already normal I am not sure I would expect much from its prolactin lowering effects however I had to run Prami several weeks to see any real benefit.
 
Yes. No issues there.

Other issues investigated:
Pituitary tumor - MRI reveals unremarkable pituitary.
Adrenal fatigue - Cortisol high in morning, DHEA-S too high (above range)... no fatigue... excess, if anything. (??)
Prolactin - normal
Iron, Magnesium - normal
Hemochromatosis - none, normal iron
Thyroid deficiency - 5+ TSH, but high-normal T4 and high-normal T3 = ??
Hashimotos - no thyroid antibodies present
Estrogen - without TRT: below mid-range; on TRT: midrange
SHBG - too low, and never rises despite high E2 or T (!)

Clomid stim. test 30mg ED for 5 days brought TT past 700 ng/dL. For real.

Psychoactive drugs failed: Prozac, Celexa, Wellbutrin, Luvox, Effexor, Lithium (!), Ativan, Abilify, Adderall

i'd look into your thyroid more. based upon what i know most 'enlightened' practitioners look for a TSH to be between 1.8-3. TSH is usually not a good test to go by in my understanding but in your case it may be providing you a clue.
 
I tried Wellbutrin XL 300mg while I was on hCG. It didn't do anything. I gave up on it after a month. One less poison in my body. My doctor wanted me to combine it with Abilify and 30mg of Adderall twice per day.


HCG does nothing for libido.

I would recommend that you try Wellbutrin again along with the gel you are taking. Give it at least 6 weeks. Stay at 150mg per day (low dose) to minimize side effects.

If your libido comes back I want you to mail me $100.00 :):cool:
 
Heavyiron, you seem to be the goto man on the subject of Pramiprexole, Seen any research concerning short term memory changes or attention disorder improvement?
On another subject, as one who is interested in drug effects, are you familiar with the effects of increasing neural acetylcholine activity?
 
Heavyiron, you seem to be the goto man on the subject of Pramiprexole, Seen any research concerning short term memory changes or attention disorder improvement?
On another subject, as one who is interested in drug effects, are you familiar with the effects of increasing neural acetylcholine activity?

Good question!

Anything you can tell us or point us to would be helpful, Heavyiron.
 
Good question!

Anything you can tell us or point us to would be helpful, Heavyiron.

FUCK! I was gonna ask you next.
I have observed that her STM is directly correlated to her interest in the event.
My notes from last Jan. listed Pram and minoclycline I think Pram is worth a try now.
The sleep study was very effective in billing Medicare for 2,000$.
 
HCG does nothing for libido.

I would recommend that you try Wellbutrin again along with the gel you are taking. Give it at least 6 weeks. Stay at 150mg per day (low dose) to minimize side effects.

If your libido comes back I want you to mail me $100.00 :):cool:


I thought the addition of hCG to a regimen is what normally restores libido and feelings of wellbeing.

I'd accept your challenge if you were willing to put something up if it didn't work. ;)
 
I thought the addition of hCG to a regimen is what normally restores libido and feelings of wellbeing.

I'd accept your challenge if you were willing to put something up if it didn't work. ;)

That's what people say... it didn't do anything for me. It felt like i was injecting water. No difference at all. Infact my anxiety went up a bit - maybe estrogen related. I also got mild chest puffyness.

Give it a shot man. 6 weeks Wellbutrin @ 150mg per day. Along with your gel.

If it doesn't work, i'll send you a poster of two chicks making out :cool::D
 
Someone please recommend a online source of pramipexole or ropinirole in tablet form, asap.
I live in europe and it will be impossible to get my doc to prescribe it. pm me. thanks.
 
Heavyiron, you seem to be the goto man on the subject of Pramiprexole, Seen any research concerning short term memory changes or attention disorder improvement?
On another subject, as one who is interested in drug effects, are you familiar with the effects of increasing neural acetylcholine activity?

Thank you for the confidence but I don't view myself as an expert just an avid reader of the science.

As far as I know Pubmed does have studies on people with Parkinson's disease who have shown changes in short term memory with Pramipexole but I don't know of any studies on healthy people in this context. Unfortunately due to the nature of Parkinson's disease I don't feel comfortable translating these findings to a healthy person.

The following link will take you to all the published studies on Pramipexole;

Mirapex (Pramipexole) - Published Studies
 
Tyler - good point.

M&M Is probably the best forum to go to for the discussion of SSRI's and other psychotropics.

I already have a case of major anhedonia. I don't desire a damned thing. Going to a casino is a complete snooze fest, as is hanging out with naked girls in a hot tub.

I'm looking for something to replace desire. Any recommendations for that, then?

Been some discussion re Prami lately so bunp you go
 
Been some discussion re Prami lately so bunp you go

First post on this board for me. I've been on prami for 2 weeks now and am just now getting past the sides. I am taking it primarily for hgh/leaning effect and have never taken steroids. As I am finally in a dose that should have the effect I'm looking for, I hope to see some results soon. I am also taking albuterol and doing cardio each day. Starting off at 27% body fat so I've got a while to go.

What I have noticed is that libido spikes come and go. On Saturday I had a small amount of chub going just about all day. Certainly, when I think about sex, it happens for me.

For sides, been through major uncontrolled sleepiness, insomnia, dizziness and almost throwing up. I kicked the dose up before bed to .8 mg and it got rid of the insomnia. In fact, last two nights have ben awesome and I don't recall waking up at all last night until alarm went off. I think the payoff is hard to get to on this stuff but think I made it through.
 
I've seen studies showing affects on short term memory with mirapex, however like stated above it was with parkinson's patients.

Mirapex also decreases acetylcholine activity. Parkinson's is speculated to be caused by a high ratio of acetylcholine to dopamine (due to DA receptor degradation) this is what causes the spasms and twitches etc. Increasing DA increases this ratio thus having the stabilizing affect on acetylcholine's action on motor neurons.

As we know acetylcholine plays a very important role in executive functioning and memory. Especially short term verbal memory.

I suspect this affect would be dose dependent, but supplementing with 5-htp and piracetam/DMAE should significantly help the problem if it is experienced.

I have an Rx for Mirapex, and I have to say the sides I experience(d) from the pharm version compared to when I "creatively sourced" it in the past are much, much less severe, this is also probably due to the 3x daily dosing though.
 
Final word on pramipexole for libido, and the reason I do NOT recommend anyone else try this:

The immediate effect was somnolence. It was hard for me to concentrate on the conversations I was having. I felt tired/exhausted, yet not sleepy.

Then, I went to sleep around 3am. Awoke at 6am with bizarre dreams, fell asleep until 9am... woke up again, went back to sleep... and finally re-awoke at 2pm feeling like myself again.

There was absolutely NO improvement in libido. I forced masturbation to see if anything would be different. Zero difference.

I took 0.5mg.


flaccido,

I had a total T of 185ng/dl when I was 17, but FT was actually at the very bottom of low normal. This is because I also have low SHBG, so 4% of my T is FT instead of 2%! Neat, huh?

Now, my natural T averages around 320ng/dl, but my FT comes back either just as low normal or even clinically low.

Problem is -- testosterone supplementation, bringing my levels up to 700ng/dl does absolutely nothing for me from a subjective standpoint.

I've never noticed an immediate effect. It makes you tired after taking it, but you have to take it for several weeks before full benefits can be judged. .25mg 3x a day is a good place to start. If you can't handle the sleepiness that occurs for a little while afterwords, then you could try twice daily dosing, but 3x works the best IME.

Also if you're not taking the pharm version there is a chance it is mixed with something else like selegiline.
 
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