Copy and pasted from EF with discussion
How to make test from dhea
experimental:
DHEA was purchased from china in one kg quantity, methanol
or methylhydrate from canadian tire, sodium borohydride from a hydrogen
cell engine supplier online fifteen grams for fifteen dollars, good for
60 grams
test. 10 grams
DHEA dissolved in 400ml methanol and stirred using
a milk frother in a regular glass nestled in ice. 2.5 grams sodium boro are
slowly added as powder at a rate that does not allow the temp
to exceed 40C.
if a slurry forms thats good, it means product is forming, just add more cold
methanol. after a total of one hour add vinegar until the bubbling on addition
stops then dump into a liter of ice water. filter thru coffe filter and squeeze
dry. dry in oven at 60C. activated manganese dioxide is made from manganese
dioxide from a ceramics supplier and then its boiled in nitirc acid
to activate.
make nitric acid by adding boiled down battery acid
to stump remover
(potassium nitrate) then boiling inside a bottle with a hose running
to another
bottle nestled in ice
to collect the nitric acid. filter and rinse with an anhydrous
solvent like a fuel system water remover, activated mang diox must be absolute dry.
put the diol from the first step in 300ml acetic acid then slowly add the mang diox as
a powder same fashion as above, stir for six
to ten hours, you won't over oxidize
since exact molar equivalents are used. now flood the reaction with five times volume
ice water and filter out the base
test plus unreacted diol and
DHEA, minimum purity
will be about 70%
Basically you're reducing the carbonyl in
DHEAto form a diol which is then randomly oxidized (
testosterone product favorable)
to get at least 70%
testosterone. The problem is that the position of the double bond in
DHEA... It is one carbon away from where it is in
testosterone... Does anyone have any ideas? How can this problem be solved or does it need
to be solved? Do you think the hormone will work like
testosterone to some degree?
many of you have seen my other posts about making steroids synthetically but always in the context of a laboratory setting, a masters in organic synthesis etc.. Lord knows over the years i have had my hands in a fair number of batches of a multitude of steroids, many of you have probably tasted my fruits but will never know.
myself and the boogeyman set out
to attempt
to do this synthesis with absolutely nothing from a scientific supply house, no glassware, no ph papers no fuck all. We succeeded and ended up with base
test so pure it crystallized like shattered glass.
THEORY:
DHEA is two synthesis steps away from
test base, one oxidation, one reduction. The most logical way is
to reduce first the 17=O
to create 5 androstenediol, this way there are many selective oxidation agents that will only convert the 3-OH
to a =O and not the 17. Since
DHEA is not water soluble one can not use water as a solvent for the reaction, the obvious choice is methanol since the reduction is done with sodium borohydride. A large excess of methanol is used because 5androdiol is much less soluble in methanol than
DHEA so as it is formed it will slurry. The second step is full of possibilities but the available selective oxidizer is manganese dioxide, in this case the reaction is done in acetic acid which gives slight solubility
to the androdiol
to transiently come in and out of solution
to react
experimental:
DHEA was purchased from china in one kg quantity, methanol or methylhydrate from canadian tire, sodium borohydride from a hydrogen cell engine supplier online fifteen grams for fifteen dollars, good for 60 grams
test. 10 grams
DHEA dissolved in 400ml methanol and stirred using a milk frother in a regular glass nestled in ice. 2.5 grams sodium boro are slowly added as powder at a rate that does not allow the temp
to exceed 40C. if a slurry forms thats good, it means product is forming, just add more cold methanol. after a total of one hour add vinegar until the bubbling on addition stops then dump into a liter of ice water. filter thru coffe filter and squeeze dry. dry in oven at 60C.
activated manganese dioxide is made from manganese dioxide from a ceramics supplier and then its boiled in nitirc acid
to activate. make nitric acid by adding boiled down battery acid
to stump remover (potassium nitrate) then boiling inside a bottle with a hose running
to another bottle nestled in ice
to collect the nitric acid. filter and rinse with an anhydrous solvent like a fuel system water remover, activated mang diox must be absolute dry. put the diol from the first step in 300ml acetic acid then slowly add the mang diox as a powder same fashion as above, stir for six
to ten hours, you won't over oxidize since exact molar equivalents are used. now flood the reaction with five times volume ice water and filter out the base
test plus unreacted diol and
DHEA, minimum purity will be about 70%
note we activated mang diox by azeotropic distillation with benzene as we are too lazy
to make nitric acid.
75 grams of
DHEA can be had for about a buck a gram, all together maybe 2-4 dollars a gram for heat free decent
test.
Bremac can correct me if I'm wrong, and there could possibly be a better way, but I think the usual route would be esterification using the corresponding acid anhydride (ie: propionic anhydride for propionate ester) in pyridine. The anhydride would be used in excess
to drive the reaction
to the desired product, since its an equilibrium rxn.
yes you can use the anhydride and that is in fact the premier way
to go, but i triple do dare you
to order propanoyl anhydride in the united states, even acetic anhydride is hot. If you go with the carboxylic acid it works but is longer reaction, plus you can form the acyl chloride from the acid which in pyridine is in my opinion just as good as the anhydride
there would be no reason at all that would make using the stuff dangerous. starting from
DHEA and reacting with sodium borohydride can produce ONLY one thing.......5androdiol. so you can have diol or
DHEA, thats it, sodium borohydride is soluble in water so when you flood the first reaction with water the hormones precipitate (become solid and filterable) and the borohydride stays behind in the liquid.
in the second step with dichromate as long as it is kept cold the only possible products are unreacted diol,
DHEA,
testosterone or androdione. the steroid skeleton lacks and signifigant chemical groups capable of allowing dangerous side reactions and by products. again dichromate is soluble in water so no contamination.
you guys need confidence in yourselves, you may not really know what i'm talking about but I don't know the difference between a dumbell and a barbell, we all have areas of expertise, i'm sure i could go workout at a gym and come out alive just as you would coming into my world.
anyone who is considering something like this should pm me there are very sympathetic chemical suppliers out there, i of course know them all.
Yeah I was thinking the acyl chloride should work as well...and in pyridine you get the pyridine HCl instead of having
to worry about generating HCl gas.
Haha I love your posts dude.
And yeah...definitely do NOT try
to order acetic anhydride....used in the manufacture of heroin, and even small amounts are reportable.
I'm glad you brought up the thing about my comment on using a carboxylic acid
to form an ester. \this is really an equilibrium reaction and the products are only slightly favoured so a huge excess of an expensive and dangerous
to obtain material like propionic acid would need
to be employed and still you would get lots of unreacted material that has really only some type of preparative chromatography as a means of separation being that the solubilities are the same.
Propionic calcium salt is available easily on ebay, this can be acidified and distilled at low temp, then chlorinated with Nchlorosuccinamide or chlorine gas or thionyl chloride etc.. its a bit of work but done in decent amount you only do it once.
still it makes more sense
to use acetyl chloride, it would form
test acetate, themost expensive of the
test esters. for what reason i have no clue. vinegar flavoured
testosterone.
