Giant Semaglutide Thread (and other GLP-1 / GIP agonists)

[Doodle]

Wanted to create a thread where everyone can post their experiences with different sourced Semaglutide.

Who are you using?
Pharma vs non?
Dosage?
How long have you been taking it?
What are your thoughts?
Have you lost weight?
Side effects?
Oral vs injection?
Tests?

 

[Ghoul]

You don't need to stay at max dosage tho for your life. Some ppl will never even reach it.

I can't even imagine being on 10mg of Tirzepatide for example, I would probably not eat for a week.

Reta doesn't give fatigue compared to TIRZ for example, that's why some ppl like it a lot more, it doesn't suppress appetite much either, another point of why.some ppl prefer it over tirz

I'm not suggesting the max dose is the "maintainance" dose. The tirz prescriber's guidelines recognize a maintainance dose can be anything from 5mg and up. For Sema. it's recommended to be at least 1.7mg, but that's a change from previous guidelines that said if you can't get to 1.7mg within 6 months, to stop treatment entirely.

They don't specify the reason why 1.7mg was a mandatory minimum before, but it could be because of another interesting property of immunogenicity. Long term, a low dose of a drug can cause more of a problem than a higher dose. By maintaining high levels of a protein drug, the body often "accepts" its presence as natural, and doesn't mount a defense like it would against small amounts.

 

[Ghoul]

Thanks for that ! Very helpful. Ill give 25mg a go for a few weeks and reassess before going any higher or adding sema in to the mix.

I’ve never understood how correctly dosed UGL tirz verified by HPLC testing wouldnt be the exact same as pharma? Isn’t it the same thing?

Impurities, in this case very minor deviations in the peptide structure, are often so close to the target peptide they're indiscernible by conventional testing methods. These "related impurities" reduce effectiveness.

Also, there can be impurities present that contribute to immunogenicity, potentially reducing the effectiveness of the peptide, that aren't detected via HPLC.

"Peptide mapping", a more advanced analysis, is used to identify these changes in structure and characterize other impurities present.

Peptide Mapping Analysis - Creative Proteomics

The peptide mapping service provided by Creative Proteomics is one of the regular indicators for the control of quality standards of protein drugs.

www.creative-proteomics.com

In addition, UGL peptides are not as stable as pharma. For instance, one factor, completely ignored in UGL is PH. The slightest deviation from the correct PH in the reconstituted solution can cause very rapid degeneration of the peptide, reducing effectiveness.