Giant Semaglutide Thread (and other GLP-1 / GIP agonists)

[Doodle]

Wanted to create a thread where everyone can post their experiences with different sourced Semaglutide.

Who are you using?
Pharma vs non?
Dosage?
How long have you been taking it?
What are your thoughts?
Have you lost weight?
Side effects?
Oral vs injection?
Tests?

 

[Ghoul]

You don't need to stay at max dosage tho for your life. Some ppl will never even reach it.

I can't even imagine being on 10mg of Tirzepatide for example, I would probably not eat for a week.

Reta doesn't give fatigue compared to TIRZ for example, that's why some ppl like it a lot more, it doesn't suppress appetite much either, another point of why.some ppl prefer it over tirz

I'm not suggesting the max dose is the "maintainance" dose. The tirz prescriber's guidelines recognize a maintainance dose can be anything from 5mg and up. For Sema. it's recommended to be at least 1.7mg, but that's a change from previous guidelines that said if you can't get to 1.7mg within 6 months, to stop treatment entirely.

They don't specify the reason why 1.7mg was a mandatory minimum before, but it could be because of another interesting property of immunogenicity. Long term, a low dose of a drug can cause more of a problem than a higher dose. By maintaining high levels of a protein drug, the body often "accepts" its presence as natural, and doesn't mount a defense like it would against small amounts.

 

[Ghoul]

Thanks for that ! Very helpful. Ill give 25mg a go for a few weeks and reassess before going any higher or adding sema in to the mix.

I’ve never understood how correctly dosed UGL tirz verified by HPLC testing wouldnt be the exact same as pharma? Isn’t it the same thing?

Impurities, in this case very minor deviations in the peptide structure, are often so close to the target peptide they're indiscernible by conventional testing methods. These "related impurities" reduce effectiveness.

Also, there can be impurities present that contribute to immunogenicity, potentially reducing the effectiveness of the peptide, that aren't detected via HPLC.

"Peptide mapping", a more advanced analysis, is used to identify these changes in structure and characterize other impurities present.

Peptide Mapping Analysis - Creative Proteomics

The peptide mapping service provided by Creative Proteomics is one of the regular indicators for the control of quality standards of protein drugs.

www.creative-proteomics.com

In addition, UGL peptides are not as stable as pharma. For instance, one factor, completely ignored in UGL is PH. The slightest deviation from the correct PH in the reconstituted solution can cause very rapid degeneration of the peptide, reducing effectiveness.

 

[Luke391]

Would Sterile water from a pharmacy be ok to reconstitute sema?

 

[Ghoul]

Would Sterile water from a pharmacy be ok to reconstitute sema?

No.

 

[RekTest]

What’s the highest tirz dose anyone here has taken? Currently on 20mg but was contemplating 30mg to try and completely nuke my appetite.

Im 1 pin into 30MG tirz and definitely not a fatty, so sampei creampei cant come for me

But it's wise to use caution, since hypoglycemia is possible,

I dont know why I didnt put two and two together, but there is times I will feel hypo, middle of the day during work.
I try to space out my food but it doesnt seem to help,

 

[Ghoul]

Im 1 pin into 30MG tirz and definitely not a fatty, so sampei creampei cant come for me




I dont know why I didnt put two and two together, but there is times I will feel hypo, middle of the day during work.
I try to space out my food but it doesnt seem to help,

I've gotten it on Sema. Vision goes blurry. Scary shit really, that can damage nerves in the eyes pretty quickly.

The mistake I was making wasn't the dose, but the dilution. .1ml hits too fast, .5ml was a more gradual rise and no hypo.

It's almost as if the pharma guys, their teams of scientists, and multi billion dollar research budgets mean they know what they're doing....

 

[RekTest]

I've gotten it on Sema. Vision goes blurry. Scary shit really, that can damage nerves in the eyes pretty quickly.

The mistake I was making wasn't the dose, but the dilution. .1ml hits too fast, .5ml was a more gradual rise and no hypo.

It's almost as if the pharma guys, their teams of scientists, and multi billion dollar research budgets mean they know what they're doing....

Ive been doing 3ML to 40mg, is that enough?

 

[Ghoul]

Ive been doing 3ML to 40mg, is that enough?

Yes that's fine. We know all doses up to 15mg Tirz are delivered in a volume of .5ml, or (roughly) 40=15mgx3 = 1.5ml minimum.

You're doubling that minimum volume.

.5ml is still ideal for all doses, but as long as you're not going below the minimum dilution used for the highest dose it's safe.

 

[Bob Sanders]

What is UGL Retatrutide typically costing per mg these days? My typical source is charging $16/mg. Do I need to do some research or is this within range?

 

[mochul]

What is UGL Retatrutide typically costing per mg these days? My typical source is charging $16/mg. Do I need to do some research or is this within range?

Jeez. A lot cheaper than that lok

 

[OldGHGuy]

Because it's not a diet pill that induces appetite suppression upon injection, and when appetite suppression lessens it's a sign of "tolerance"

It's a hormone that plays a central part in energy homeostasis, ie, the weight your body wants to maintain.

The way to envision it is this.

Someone is 250lbs.

You boost your natural GLP level with a .5mg dose of Semaglutide.

Now your homeostasis weight is 240. Since you're above the "set weight", ie homeostasis, the entire biological energy regulatory system, including the complex of effects we refer to as "appetite", physical and psychological, kick in to reduce your weight.

Once you reach the set weight of 240, as determined by how much of the GLP is in your system, appetite suppression stops. If you stay on the same dose, and force yourself to eat more, gaining weight, appetite suppression will return to push you back towards 240.

So to go lower, you increase the dose to .75mg.

Now your homeostasis weight is 230, and appetite suppression returns, until you reach that level.

Once you reach your goal weight, and there's no further appetite suppression, that's the "maintainance dose", at which you maintain the same weight indefinitely.

Because the greater the distance you are from the homeostasis weight set by GLP level and your actual weight, the more intense the effects are, the dose is raised gradually.

Great explanation. Thanks @Ghoul

 

[Rkl]

Jeez. A lot cheaper than that lok

1-1.2$/ mg is common

 

[Rkl]

What is UGL Retatrutide typically costing per mg these days? My typical source is charging $16/mg. Do I need to do some research or is this within range?

Also all Reta is UGL

 

[Bob Sanders]

1-1.2$/ mg is common

Thank you.

Found QSC. Thanks for saving me a lot of money, Meso . Won't be using any of these American peptide sites ever again.

 

[Luke391]

Hey guys, usually how are the side effects of sema comparted to tirz? I know that tirzepatide is generally tolerated better but how much worse can sema's side effects be?

 

[Ghoul]

Hey guys, usually how are the side effects of sema comparted to tirz? I know that tirzepatide is generally tolerated better but how much worse can sema's side effects be?

Potentially much worse if precautions aren't taken to minimize them. They can ambush you, because of the way timing works with these hormones.

However, after 6-8 weeks of proper use, they diminish greatly, By the time you reach a maintainance dose, they're essentially non-existent.

 

[Luke391]

Potentially much worse if precautions aren't taken to minimize them. They can ambush you, because of the way timing works with these hormones.

However, after 6-8 weeks of proper use, they diminish greatly, By the time you reach a maintainance dose, they're essentially non-existent.

thank you very much. About the maintnance dose, if one is not able to reach 1.7mg a week because that dose is too high for them, could staying on a lower dose (like 0.25 to 1mg or whatever they find to be better) cause a tolerance to the drug?

 

[Ghoul]

thank you very much. About the maintnance dose, if one is not able to reach 1.7mg a week because that dose is too high for them, could staying on a lower dose (like 0.25 to 1mg or whatever they find to be better) cause a tolerance to the drug?

Yes. Novo has determined any dose is acceptable as a maintainance dose, but they still recommend trying to get to 1.7 if possible.

 

[Here2Learn]

Hey guys, usually how are the side effects of sema comparted to tirz? I know that tirzepatide is generally tolerated better but how much worse can sema's side effects be?

I couldn’t get past the exhaustion, I had no energy to do anything including at work. You really have to make sure you are hitting your protein goal and getting enough calories on Sema. Even with that and giving it a few months it didn’t get better for me. I have a friend on 1mg and she has done amazing. It seems each person adapts better to a specific GLP than others so really it only comes down to how you feel on it.