Protocol for tirz

[Obeast88]

Just seeing what everyone has done after using tirz, coming off and going back on. Plan on starting it back within a couple days and just looking for info on dosing protocols if you’ve already been on it before. Did you start at the 2.5mg a week dose or did you start higher. If higher did you notice any sides that u didn’t have before or any at all. Thanks for the help. I know everyone’s different and responses to it will not be the same just looking a general area of disease for restarting to have the affects intended.

 

[Obeast88]

Any help would be grateful bc I haven’t found any information on this after using the first time and I realize I should have chNged the thread title probably

 

[Xscense]

Started at 2.5mg 1x week, but have not had a need to increase as it works great for me at this dose. Intermittently, I’ve had breaks or extended dosing window due to travel or if I feel it’s still too strong on appetite suppression.

I’ve had no sides, outside of less energy - but consuming a lot less calories, so it’s to be expected.

 

[Obeast88]

Ok thanks that’s what want it for just appetite suppression and insulin control so I was thinking doing 2,5 or 5 mg once ever 5-7 days but I want to keep it low as I can but last time I got up to 12.5mg a week bc the hunger just kept coming lol I’m trying to cut down and retain muscle so hopefully the gh help with and debating on npp just to prove a point that it can be done and look good

 

[WeaponPharma]

Hey mate - I start on 5mg - run it at that dose for a few months-then come off. Starting again soon, but think I’ll push to 10mg pretty quickly

 

[Sector]

I started on 2.5mg but split my doses into 2x a week

Once it started to lose effectiveness I went up to 5mg/week, split into 2 doses a week

Once 5mg lost it's effectiveness I rotated to semaglutide and it felt like my tolerance basically reset, so I'll rotate between the two when my dose starts getting high going forward

 

[sbtr12]

I started on 2.5mg but split my doses into 2x a week

Once it started to lose effectiveness I went up to 5mg/week, split into 2 doses a week

Once 5mg lost it's effectiveness I rotated to semaglutide and it felt like my tolerance basically reset, so I'll rotate between the two when my dose starts getting high going forward

I am not a fan of taking 2X a week.

The pharma protocol is 2.5mg for 4 weeks, then bump up 2.5 mg per month (1 dose a week) until either the sides become too much (also monitor bloods) or you are experiencing significant weight loss, at which point you can use your dose as a maintenance dose.

Its a bit different for this community as many are not morbidly obese or even really obese at all. Since you have used it before, I recommend:
1) 2.5 mg for 2 weeks
2) 5 mg for 2 weeks
3) 7.5mg for 1 month (possibly maintenance dose)

If I ran it like suggested above I would get bloods after 2 weeks of 7.5 mg if no side effects to confirm nothing wrong with markers. If weight loss not sufficient I would continue to bump up 2.5 mg and take for a month, etc.

 

[Sector]

I am not a fan of taking 2X a week.

The pharma protocol is 2.5mg for 4 weeks, then bump up 2.5 mg per month (1 dose a week) until either the sides become too much (also monitor bloods) or you are experiencing significant weight loss, at which point you can use your dose as a maintenance dose.

Its a bit different for this community as many are not morbidly obese or even really obese at all. Since you have used it before, I recommend:
1) 2.5 mg for 2 weeks
2) 5 mg for 2 weeks
3) 7.5mg for 1 month (possibly maintenance dose)

If I ran it like suggested above I would get bloods after 2 weeks of 7.5 mg if no side effects to confirm nothing wrong with markers. If weight loss not sufficient I would continue to bump up 2.5 mg and take for a month, etc.

The pharma protocol is for people that are diabetic, or morbidly obese.

There's no point in increasing the dosage if it hasn't lost effectiveness. If 2.5mg/week works for you, you don't need to go to 5mg just because that's what they reccomdnd for diabetics.

Pharma companies also have incentive to ramp the doses faster, so that they can make more money.

So respectfully I disagree with you. Stick with 2.5mg/week until it loses effectiveness then increase the dose, otherwise you could ramp the dose too quickly and start getting sides.

 

[sbtr12]

The pharma protocol is for people that are diabetic, or morbidly obese.

There's no point in increasing the dosage if it hasn't lost effectiveness. If 2.5mg/week works for you, you don't need to go to 5mg just because that's what they reccomdnd for diabetics.

Pharma companies also have incentive to ramp the doses faster, so that they can make more money.

So respectfully I disagree with you. Stick with 2.5mg/week until it loses effectiveness then increase the dose, otherwise you could ramp the dose too quickly and start getting sides.

Read my entire post bro. You said almost the same thing I did.

I started with the pharma protocol as the first talking point, then I elaborated about most in this community.and stated how we are not morbidly obese....did not discuss diabetic as the convo was more about weight loss but tirz is tirz and the pharma protcol is the same whether its meant for pre-diabetes/diabetes (Mounjaro) or weight loss (Zepbound),

For the most part I think we agree.

What I left out is that I see many in the forums say that 5mg or 7.5 mg work well. Like you, I do believe that whatever is working well, stay at that dose as maintenance, especially if you are not noticing major side effects.

Also I do agree, if 2.5 works for someone, stick with it.

2.5 did jack shit for me. At 5, I noticed a bit of a difference, I noticed a little bit more of a difference at 7.5 and I suspect my sweet spot wlll be 10 mg (we shall see).

My body type is more a PL body. i have some cuts but never a desire to be on a BB stage. Now the BB type I would for sure recommend what you said as they generally have low BF to begin with.

 

[Sector]

Read my entire post bro. You said the same thing I did.

I started with the pharma protocol as the first talking point, then I elaborated about most in this community.and stated how we are not morbidly obese....did not discuss diabetic as the convo was more about weight loss but tirz is tirz and the pharma protcol is the same whether its meant for pre-diabetes/diabetes (Mounjaro) or weight loss (Zepbound),

For the most part I think we agree.

What I left out is that I see many in the forums say that 5mg or 7.5 mg work well. Like you, I do believe that whatever is working well, stay at that dose as maintenance, especially if you are not noticing major side effects.

Fair point. I guess I was just trying to emphasis a slower approach to titrating the dose. Waiting for results to stall, then increasing, rather than doing it on a pre determined timeline

Because then tolerance just builds much faster if you ramp the dose quickly

 

[sbtr12]

Fair point. I guess I was just trying to emphasis a slower approach to titrating the dose. Waiting for results to stall, then increasing, rather than doing it on a pre determined timeline

Because then tolerance just builds much faster if you ramp the dose quickly

Agree and my recommendation was based largely on my own experience and some others with similar body types as mine which I did not point out in my original message, so I can see where you are coming from.

I believe your recommendation overall is better to start at the lowest dose and keep whatever works as the maintenance dose (only increase dose if no results seen after a month IMO).

 

[PatriotsEnjoyer]

I started on 2.5mg but split my doses into 2x a week

Once it started to lose effectiveness I went up to 5mg/week, split into 2 doses a week

Once 5mg lost it's effectiveness I rotated to semaglutide and it felt like my tolerance basically reset, so I'll rotate between the two when my dose starts getting high going forward

I followed a similar protocol to you. Started st 2.5mg split into two shots and slowly titrated up. I didn't switch off Tirz though. I've read it has less side effects than Sema so I stayed with it. Fortunately I discovered bulk shippers or I would have definitely jumped to Sema just because of cost. I eventually got up to 10mg a week.

Had great results. I will probably run this every spring.

 

[Obeast88]

Read my entire post bro. You said almost the same thing I did.

I started with the pharma protocol as the first talking point, then I elaborated about most in this community.and stated how we are not morbidly obese....did not discuss diabetic as the convo was more about weight loss but tirz is tirz and the pharma protcol is the same whether its meant for pre-diabetes/diabetes (Mounjaro) or weight loss (Zepbound),

For the most part I think we agree.

What I left out is that I see many in the forums say that 5mg or 7.5 mg work well. Like you, I do believe that whatever is working well, stay at that dose as maintenance, especially if you are not noticing major side effects.

Also I do agree, if 2.5 works for someone, stick with it.

2.5 did jack shit for me. At 5, I noticed a bit of a difference, I noticed a little bit more of a difference at 7.5 and I suspect my sweet spot wlll be 10 mg (we shall see).

My body type is more a PL body. i have some cuts but never a desire to be on a BB stage. Now the BB type I would for sure recommend what you said as they generally have low BF to begin with.

Yeah this is kind of where I was at with it. 2.5 does jack shit for me either so im going with the 5mg once weekly bc i never noticed anything off split doses like others like to do. Just want to stay at maintenance to do a recomp at this time nothing drastic for this cycle just been off for awhile and this damn sus makes me hungry asf and idk why!!! Test e has never made me as hungry as sus and I need the toes to work fast lol and I won’t be switching either to sema. I have never ran sema bc everything I’ve learned is Tirz is better in all aspects except price, but I have 510 mg on deck so I should be good for awhile

 

[Boisland]

Just seeing what everyone has done after using tirz, coming off and going back on. Plan on starting it back within a couple days and just looking for info on dosing protocols if you’ve already been on it before. Did you start at the 2.5mg a week dose or did you start higher. If higher did you notice any sides that u didn’t have before or any at all. Thanks for the help. I know everyone’s different and responses to it will not be the same just looking a general area of disease for restarting to have the affects intended.

I've been on a 2.5 every 7 days since March, then every 5 rather than titrate up to keep appetite suppression down. Added Reta 2.5 same schedule recently, as well as Tesamorelin 1 mg daily for abdominal fat reduction (or so its been researched as) Finding the balance to keep appetite suppression up, fatigue reduced/that one is difficult. But lost 35lbs since the 3/1 start, with a lb or so every week. Slow n steady goes this glue horse, lol. I've been on HRT -T for a few years and on shot week that seems to help with fatigue.

 

[Sampei]

What markers? You are talking about drawing blood but what one should look for? Doesn't make much sense

I am not a fan of taking 2X a week.

The pharma protocol is 2.5mg for 4 weeks, then bump up 2.5 mg per month (1 dose a week) until either the sides become too much (also monitor bloods) or you are experiencing significant weight loss, at which point you can use your dose as a maintenance dose.

Its a bit different for this community as many are not morbidly obese or even really obese at all. Since you have used it before, I recommend:
1) 2.5 mg for 2 weeks
2) 5 mg for 2 weeks
3) 7.5mg for 1 month (possibly maintenance dose)

If I ran it like suggested above I would get bloods after 2 weeks of 7.5 mg if no side effects to confirm nothing wrong with markers. If weight loss not sufficient I would continue to bump up 2.5 mg and take for a month, etc.

 

[hungryalways]

2.5mg every 4-5 days, and I can easily hit a 1,000 calorie deficit until I hit goal weight/bodyfat, then stop.

The first run was multiple months, and I started to feel a little malnourished and had some whacky iron results in bloods. Now I only need to run it for a few weeks to trim of the excess fat put on during bulks.

 

[Sideshowjacked]

Anyone tried with test cyp and mast ?

 

[sbtr12]

What markers? You are talking about drawing blood but what one should look for? Doesn't make much sense

In the United States, if you get tirz prescribed for diabetes/pre-diabetes or for obesity, most doctors will want to monitor bloods for allergic reactions, markers of normal side effects and markers of more rare but serious side effects like pancreatitis or gall bladder issues.

Now I know and already stated that most here are not like the avg Joe going to the doc to get Tirz. Still my opinion and advice were mostly based on my experience and what I have seen with others.

If you don't care or worry about possible side effects, then you wouldn't need to pull bloods. IMO, I want to rule out any dangerous side effects especially because I take other drugs. In addition to the above, there is much that is not known about Tirz (meaning clinical trials over time) so just to be safe, I recommend at least getting the basic CBC and metabolic panels and possibly an iron panel.

The reasoning: To check for markers like bilirubin, wbc counts, eosinophils, CRP etc.... Obviously a doc would look at glucose and A1C as well.

Some people do have an allergic reaction to tirz and can get violently sick although they may not get sick until they reach a certain threshold with their dosage. High eosinophils will likely result with that scenario. The other markers I mentioned would look for inflammation and possible issues with the pancreas, liver and/or gall bladder.

Anyway, just my opinion especially because many here don't follow the standard dosing protocol for Zepbound/Mounjaro. Those that don't follow the standard dosing tend to take less than what doctors prescribe and therefore if you are one of those people, perhaps it would not make much sense to worry about any sides and pull bloods.

One other point to consider if you source from a UGL is that you don't really know for sure what you are dealing with unless you have sent in a sample for HPLC testing. Another good reason to monitor your bloods if you dont test before taking.

PS- forgot electrolytes can get thrown off too with Tirz (usually due to dehydration) and CBC panels will include the most crucial electrolyte analyses.

 

[sbtr12]

Yeah this is kind of where I was at with it. 2.5 does jack shit for me either so im going with the 5mg once weekly bc i never noticed anything off split doses like others like to do. Just want to stay at maintenance to do a recomp at this time nothing drastic for this cycle just been off for awhile and this damn sus makes me hungry asf and idk why!!! Test e has never made me as hungry as sus and I need the toes to work fast lol and I won’t be switching either to sema. I have never ran sema bc everything I’ve learned is Tirz is better in all aspects except price, but I have 510 mg on deck so I should be good for awhile

I have tried both and both work well for weight loss but sides are less and much more tolerable with tirz.

 

[Sampei]

In the United States, if you get tirz prescribed for diabetes/pre-diabetes or for obesity, most doctors will want to monitor bloods for allergic reactions, markers of normal side effects and markers of more rare but serious side effects like pancreatitis or gall bladder issues.

Now I know and already stated that most here are not like the avg Joe going to the doc to get Tirz. Still my opinion and advice were mostly based on my experience and what I have seen with others.

If you don't care or worry about possible side effects, then you wouldn't need to pull bloods. IMO, I want to rule out any dangerous side effects especially because I take other drugs. In addition to the above, there is much that is not known about Tirz (meaning clinical trials over time) so just to be safe, I recommend at least getting the basic CBC and metabolic panels and possibly an iron panel.

The reasoning: To check for markers like bilirubin, wbc counts, eosinophils, CRP etc.... Obviously a doc would look at glucose and A1C as well.

Some people do have an allergic reaction to tirz and can get violently sick although they may not get sick until they reach a certain threshold with their dosage. High eosinophils will likely result with that scenario. The other markers I mentioned would look for inflammation and possible issues with the pancreas, liver and/or gall bladder.

Anyway, just my opinion especially because many here don't follow the standard dosing protocol for Zepbound/Mounjaro. Those that don't follow the standard dosing tend to take less than what doctors prescribe and therefore if you are one of those people, perhaps it would not make much sense to worry about any sides and pull bloods.

One other point to consider if you source from a UGL is that you don't really know for sure what you are dealing with unless you have sent in a sample for HPLC testing. Another good reason to monitor your bloods if you dont test before taking.

PS- forgot electrolytes can get thrown off too with Tirz (usually due to dehydration) and CBC panels will include the most crucial electrolyte analyses.

That's excellent information, thank you. I pull blood every two months on average and check all the usual stuff (liver, kidneys, CBC, glucose, cholesterol etc.) so shouldn't be a problem.