A fellow brother recently had a thread going with concerns with his "first tren cycle". The discussion soon turned into how to combat or hinder sides.
So lets talk about this shall we?
Tren is the compound that's well known for having a love hate relationship with most users. Most will deem it a necessary evil. But, in fact it doesn't have to be classified as evil after all.
Allow me to intro some clinical studies that have been conducted with a compound most commonly known as Proviron-trade name (Mesterolone).This agent posses some amazing characteristics with Antidepressant properties, as well Antianxiety.
It works by also metabolizing and being recognized through the endocrine as (other) a neurosteroid,effectively functioning as a so-called proneurosteroid (Testosterone is also recognized as one).. These steroids synthesized in the brain (Proviron especially) and have effects on brain function,In addition to their actions on neuronal membrane receptors,improving the quality of the channels that cells use to communicate and interact.
Proviron(mesterolone) will exert inhibitory actions on neurotransmission, acting as potent positive allosteric modulator of the GABA receptor (This is crucial concerning Tren-Insomnia as healthly function levels of GABA will produce a stable sleep state/environment for rest) and possess, in no particular order, antidepressant,sress-reducing, feeling warm/fuzzy/rewarding,pro-social, antiaggressive(huge consider tren sides),prosexual,sedative/prosleep,cognitive-memory improvement..The list goes on!
(Where does this apply with Tren? It can aid all the way around with individuals how are sensitive or not.From the social aspect,overwhelming sense of anxiety,lack of sleep,basically every stated above that may apply with the usage of tren and the onset of its unwanted side)
In addition to this information, an individual can also utilized Masteron (Drostanolonein) in conjunction with Proviron, running both concurrent may yield a great synergenic effect,each compound will compliment one an other.
Below is a image illustrating the neurotransmitter/receptor and how it functions, also I will include some real actual studies conducted with proven results expressing the benefits of this compound (proviron)
Keep in mind that these doses may seem extreme,its been proven time and time again that such significant dosages are not needed to yield the effect. Merely a daily intake of 50-100 will suffice for almost anyone!
Citation
Database: PsycINFO
[ Journal Article ]
A comparison of the antidepressant effects of a synthetic androgen (mesterolone) and amitriptyline in depressed men.
Vogel, William; Klaiber, Edward L.; Broverman, Donald M.
Journal of Clinical Psychiatry, Vol 46(1), Jan 1985, 6-8.
Abstract
The effects of mesterolone, a male sex hormone in depressed patients (a double blind controlled study).
Itil TM, Michael ST, Shapiro DM, Itil KZ.
Abstract
Based on computer EEG (CEEG) profiles, in high doses, antidepressant properties of mesterolone, a synthetic androgen, were predicted. In a double-blind placebo controlled study, the clinical effects of 300-450 mg daily mesterolone were investigated in 52 relatively young (age range 26-53 years, mean 42.7 years) male depressed outpatients. During 6 weeks of mesterolone treatment, there was a significant improvement of depressive symptomatology. However, since an improvement was also established during the placebo treatment, no statistically appreciable difference in the therapeutic effects of mesterolone was established compared to placebo. Mesterolone treatment significantly decreased both plasma testosterone and protein bound testosterone levels. Patients with high testosterone levels prior to treatment seem to have had more benefit from mesterolone treatment than patients with low testosterone levels. The degree of improvement weakly correlated to the decrease of testosterone levels during mesterolone treatment.
So lets talk about this shall we?
Tren is the compound that's well known for having a love hate relationship with most users. Most will deem it a necessary evil. But, in fact it doesn't have to be classified as evil after all.
Allow me to intro some clinical studies that have been conducted with a compound most commonly known as Proviron-trade name (Mesterolone).This agent posses some amazing characteristics with Antidepressant properties, as well Antianxiety.
It works by also metabolizing and being recognized through the endocrine as (other) a neurosteroid,effectively functioning as a so-called proneurosteroid (Testosterone is also recognized as one).. These steroids synthesized in the brain (Proviron especially) and have effects on brain function,In addition to their actions on neuronal membrane receptors,improving the quality of the channels that cells use to communicate and interact.
Proviron(mesterolone) will exert inhibitory actions on neurotransmission, acting as potent positive allosteric modulator of the GABA receptor (This is crucial concerning Tren-Insomnia as healthly function levels of GABA will produce a stable sleep state/environment for rest) and possess, in no particular order, antidepressant,sress-reducing, feeling warm/fuzzy/rewarding,pro-social, antiaggressive(huge consider tren sides),prosexual,sedative/prosleep,cognitive-memory improvement..The list goes on!
(Where does this apply with Tren? It can aid all the way around with individuals how are sensitive or not.From the social aspect,overwhelming sense of anxiety,lack of sleep,basically every stated above that may apply with the usage of tren and the onset of its unwanted side)
In addition to this information, an individual can also utilized Masteron (Drostanolonein) in conjunction with Proviron, running both concurrent may yield a great synergenic effect,each compound will compliment one an other.
Below is a image illustrating the neurotransmitter/receptor and how it functions, also I will include some real actual studies conducted with proven results expressing the benefits of this compound (proviron)
Keep in mind that these doses may seem extreme,its been proven time and time again that such significant dosages are not needed to yield the effect. Merely a daily intake of 50-100 will suffice for almost anyone!
Citation
Database: PsycINFO
[ Journal Article ]
A comparison of the antidepressant effects of a synthetic androgen (mesterolone) and amitriptyline in depressed men.
Vogel, William; Klaiber, Edward L.; Broverman, Donald M.
Journal of Clinical Psychiatry, Vol 46(1), Jan 1985, 6-8.
Abstract
- 26 depressed male outpatients were randomly assigned to 14 wks of treatment with either mesterolone or amitriptyline in a double-blind parallel treatment design. Ss completed the Hamilton Rating Scale for Depression and a symptom checklist each week. Findings reveal that the drugs were equally effective in reducing depressive symptoms. Mesterolone produced significantly fewer adverse side effects than amitriptyline and did not produce hypomania or tachycardia, recognized side effects of amitriptyline. (10 ref) (PsycINFO Database Record (c) 2013 APA, all rights reserved)
The effects of mesterolone, a male sex hormone in depressed patients (a double blind controlled study).
Itil TM, Michael ST, Shapiro DM, Itil KZ.
Abstract
Based on computer EEG (CEEG) profiles, in high doses, antidepressant properties of mesterolone, a synthetic androgen, were predicted. In a double-blind placebo controlled study, the clinical effects of 300-450 mg daily mesterolone were investigated in 52 relatively young (age range 26-53 years, mean 42.7 years) male depressed outpatients. During 6 weeks of mesterolone treatment, there was a significant improvement of depressive symptomatology. However, since an improvement was also established during the placebo treatment, no statistically appreciable difference in the therapeutic effects of mesterolone was established compared to placebo. Mesterolone treatment significantly decreased both plasma testosterone and protein bound testosterone levels. Patients with high testosterone levels prior to treatment seem to have had more benefit from mesterolone treatment than patients with low testosterone levels. The degree of improvement weakly correlated to the decrease of testosterone levels during mesterolone treatment.