PT - 141

[accidentaljedi173]

Can't stand that stuff, Works better than cialis "on demand", but the sides are terrible. I hate the "blue shift" in vision. Everything looks like it's lit by police station fluorescent lighting.

PT-141 much better, low dose daily cialis, or both.

I wanted to switch to both. Just not exactly clear if I should be taking the pt-141 like I would sildenafil, or if I should be on a regular schedule with it.

 

[Ghoul]

I wanted to switch to both. Just not exactly clear if I should be taking the pt-141 like I would sildenafil, or if I should be on a regular schedule with it.

Start with low dose daily Cialis. You may need a month to acclimate and get passed the sides (if you have any). That alone may do everything you need, and it'll certainly help, while being good for your overall cardiovascular health.

If you've been suffering from ED or low libido for a while, consider the PT-141 a "jump start". The correct dose will make you very horny and extremely sensitive. The first few times may be a little bit of an ordeal. There's some nausea typically with the first few uses. GI side effects can hit later or the next day, (eat light the first day you try it) similar to GLPs. Very long lasting erections (but it's not priapism) aren't necessarily fun if there's no outlet,

So PT can be a commitment, especially the first few uses. You should try to use it under low pressure conditions (or solo) the first time to gauge your response, This is not simple like Viagra.

Once you know what you're dealing with, you can inject 30-60 minutes prior to action, and enjoy ongoing effects for up to 2 days.

 

[kaizoku]

That plus Cialis gotta be fun

I’ve never taken PT-141 but Cialis and MT2 is a good time.

Just don’t mix either or both of them with trazodone…

 

[HUGE McBIGLARGE]

Post in thread 'Qingdao Sigma Chemical Co., Ltd (International, US, EU, Canada and Australia domestic'

Sep 19, 2024

Not just boners, just overall drive. I've read men and women taking both oxytocin and pt141 for an increase in drive and overall pleasure. From what I read Oxytocin can have some side effects like increased heart rate, ect..

Just looking for feedback from anyone who's tried.

PT-141 has nothing in common with ED meds like Cialis or Viagra. These only work on the "plumbing", while PT works on the sexual pleasure center in the brain. That's often enough to "punch" through any physical ED though. It's so potent it's been used to restore sensation in men with spinal cord injuries...

• Ghoul

• 

I’ve been doing some reading, and it seems mt2 and by extension pt141 can cause a big loss of lean body mass. Opinion?

Activation of the central melanocortin system chronically reduces body mass without the necessity of long-term caloric restriction - PMC

Melanotan II (MTII) is a potent appetite suppressor that rapidly reduces body mass. Given the rapid loss of anorexic response upon chronic MTII treatment, most investigations have focused on the initial physiological adaptations. However, other ...

pmc.ncbi.nlm.nih.gov

“muscle wasting is a concerning outcome”

“skeletal muscle tissue mass was lower by 30% in the high-dose MTII group compared to the aCSF group”

That’s a big percentage! I caught a glimpse of myself in a window while getting petrol and either bigorexia was fucking with me, or I’m the smallest I’ve been in a long time. I’m gonna have to change my name to Little McTinysmall

 

[Nidus]

I’ve been doing some reading, and it seems mt2 and by extension pt141 can cause a big loss of lean body mass. Opinion?

Activation of the central melanocortin system chronically reduces body mass without the necessity of long-term caloric restriction - PMC

Melanotan II (MTII) is a potent appetite suppressor that rapidly reduces body mass. Given the rapid loss of anorexic response upon chronic MTII treatment, most investigations have focused on the initial physiological adaptations. However, other ...

pmc.ncbi.nlm.nih.gov

“muscle wasting is a concerning outcome”

“skeletal muscle tissue mass was lower by 30% in the high-dose MTII group compared to the aCSF group”

That’s a big percentage! I caught a glimpse of myself in a window while getting petrol and either bigorexia was fucking with me, or I’m the smallest I’ve been in a long time. I’m gonna have to change my name to Little McTinysmall

I believe AAS negate this fully, i mean most bodybuilders use MT2 during prep and for shows, none of them get "smaller"
The study also talks about reduced food in-take and central melanocortin system seems to be slowing down AMPK Activation which would be triggered through AAS regardless.

There is also that: Central melanocortin signaling restores skeletal muscle AMP-activated protein kinase phosphorylation in mice fed a high-fat diet - PubMed

Feel free to correct me, just my 2 findings from that.

 

[HUGE McBIGLARGE]

I believe AAS negate this fully, i mean most bodybuilders use MT2 during prep and for shows, none of them get "smaller"

They also lean out big time, which will cause some muscle loss. It seems MT2 causes more fat loss than muscle loss, so they probably want this side effect anyway.

The study also talks about reduced food in-take

Only for 5 days

“central MTII administration induced a transient anorexia lasting 5 days”

“We also performed a separate one-way ANOVA with nonrepeated measures to compare daily food intake prior to MTII treatment (day 0), in the middle (day 19), and at the end (day 40) of the study. No significant difference in food consumption was reported for these 3 days (Figs. 2a–2c). Cumulative energy intake for the duration of the study was not affected by any treatment”

There is also that: Central melanocortin signaling restores skeletal muscle AMP-activated protein kinase phosphorylation in mice fed a high-fat diet - PubMed

Feel free to correct me, just my 2 findings from that.

Yeah that’s good at least lol

 

[Nidus]

They also lean out big time, which will cause some muscle loss. It seems MT2 causes more fat loss than muscle loss, so they probably want this side effect anyway.


Only for 5 days

“central MTII administration induced a transient anorexia lasting 5 days”

“We also performed a separate one-way ANOVA with nonrepeated measures to compare daily food intake prior to MTII treatment (day 0), in the middle (day 19), and at the end (day 40) of the study. No significant difference in food consumption was reported for these 3 days (Figs. 2a–2c). Cumulative energy intake for the duration of the study was not affected by any treatment”


Yeah that’s good at least lol

I believe @Ghoul linked this a month ago or so but PT141 is also in trial together with Tirza for addicts and obese people as this also seem to be helping.

Me personally, i am a huge fan of microdosing 200-300mcg of PT141 1-2x a week. That wit Cialis, low prolactin and an E2 in range gives you the ability to drill holes through walls.

I am also running 12.5mg of Tirza a week atm and did not really notice much from the combination in terms of cravings

Pretty interesting studies out there regarding MT2 and PT141 though!

 

[krusty28]

Just thought I'd throw my experience in. Tried PT Friday night with my ex. On recommendations here regarding dosage, (essentially go big or go home lol) I took 3mg and gave my girl 2mg. We both had minor nausea but no headache. within 45min or less of taking both had a sense of euphoria and skin felt sensitive. Within an hour we were horny as fuck. I had taken my daily 5mg cialis and maybe another 40mg earlier as we were drinking and did a few bumps. Anyway i had an absolute raging hard on i would say for close to 36 hours. yes it went down here and there but even when soft it was chubb enough i couldn't go out in public. lol As for her she was horny as fuck and sensitive for the same amount of time that first Friday night she was squirting everywhere i mean like a fountain and that not something that has happened that easily and that much ever before. The next day it was the same. as soon as i touched her it was game on. So in conclusion PT 141 is amazing i recommend taking a large dose so that your libido out weighs your nausea and can't wait to do it again as I've heard the nausea dissipates with further use. enjoy

 

[krusty28]

I believe @Ghoul linked this a month ago or so but PT141 is also in trial together with Tirza for addicts and obese people as this also seem to be helping.

Me personally, i am a huge fan of microdosing 200-300mcg of PT141 1-2x a week. That wit Cialis, low prolactin and an E2 in range gives you the ability to drill holes through walls.

I am also running 12.5mg of Tirza a week atm and did not really notice much from the combination in terms of cravings

Pretty interesting studies out there regarding MT2 and PT141 though!

I may try the micro dose route when i have plans for a new girl to come over on the weekend, rather then jamming myself secretly an hour before lol.

 

[HUGE McBIGLARGE]

I've heard the nausea dissipates with further use. enjoy

I stopped all MCR agonists about 6 months ago. Started mt2 again a few days ago at 1mg per day, and no sides at all except for boners.

First time I ever dosed 1mg of pt141 I nearly threw up, and my face was red for a few hours.

So yeah, the sides went and didn’t come back

 

[Ghoul]

I’ve been doing some reading, and it seems mt2 and by extension pt141 can cause a big loss of lean body mass. Opinion?

Activation of the central melanocortin system chronically reduces body mass without the necessity of long-term caloric restriction - PMC

Melanotan II (MTII) is a potent appetite suppressor that rapidly reduces body mass. Given the rapid loss of anorexic response upon chronic MTII treatment, most investigations have focused on the initial physiological adaptations. However, other ...

pmc.ncbi.nlm.nih.gov

“muscle wasting is a concerning outcome”

“skeletal muscle tissue mass was lower by 30% in the high-dose MTII group compared to the aCSF group”

That’s a big percentage! I caught a glimpse of myself in a window while getting petrol and either bigorexia was fucking with me, or I’m the smallest I’ve been in a long time. I’m gonna have to change my name to Little McTinysmall

That loss was in proportion to overall weight (fat) loss though, which is pretty normal.

In any case, I'll cancel my plans to load an insulin pump to continuously deliver MT-II like I planned...

 

[Ghoul]

I stopped all MCR agonists about 6 months ago. Started mt2 again a few days ago at 1mg per day, and no sides at all except for boners.

First time I ever dosed 1mg of pt141 I nearly threw up, and my face was red for a few hours.

So yeah, the sides went and didn’t come back

I'd love to find out why that is the case, but an "immunity" to sides developing does seem to be pretty consistant.

 

[Ghoul]

I may try the micro dose route when i have plans for a new girl to come over on the weekend, rather then jamming myself secretly an hour before lol.

Definately don't try for the first time under pressure. Go solo, I'd just go straight to 1.7mg at least, Just like Vyleesi users do when it's prescribed.

Eat lightly that day though...

 

[HUGE McBIGLARGE]

That loss was in proportion to overall weight (fat) loss though, which is pretty normal.

But it’s far easier to lose fat than gain muscle

In any case, I'll cancel my plans to load an insulin pump to continuously deliver MT-II like I planned...

lol aye. We’re not on a drip of MCRAs, and we’re not rats, but I see that 30% muscle loss and get scared. And the efficacy of MT2 persists longer than its circulation. As I can take MT2 before bed and get big erections all day tomorrow.

Hopefully the fat and muscle loss is due to the increased oxygen consumption, suggesting an up regulation of thermogenesis without up regulation of appetite, thus causing net energy loss.

But if it affects non-feeding underlying mechanisms behind muscle growth and retention, then I’m not happy taking it lol

 

[Ghoul]

But it’s far easier to lose fat than gain muscle

lol aye. We’re not on a drip of MCRAs, and we’re not rats, but I see that 30% muscle loss and get scared. And the efficacy of MT2 persists longer than its circulation. As I can take MT2 before bed and get big erections all day tomorrow.

Hopefully the fat and muscle loss is due to the increased oxygen consumption, suggesting an up regulation of thermogenesis without up regulation of appetite, thus causing net energy loss.

But if it affects non-feeding underlying mechanisms behind muscle growth and retention, then I’m not happy taking it lol

I love MT-II, and not just for the tan.

It's definitely an appetite suppressant, but I suspect they're onto something, because I've always felt more energetic on it. Not stimulant energy, but movement seems to require less effort. Everything "lighter".

 

[HUGE McBIGLARGE]

I love MT-II, and not just for the tan.

It's definitely an appetite suppressant, but I suspect they're onto something, because I've always felt more energetic on it. Not stimulant energy, but movement seems to require less effort. Everything "lighter".

My mum and I have noticed we run a lot warmer on it.

My mum didn’t have the heating on all winter, but she ran out of MT2 the other week and said within a week she needed the heating on, despite it going from winter weather to summer weather.

 

[AlexDavis43]

I believe AAS negate this fully, i mean most bodybuilders use MT2 during prep and for shows, none of them get "smaller"

what are you talking about dude

All bodybuilders get smaller during prep.

Who uses MT2 during prep, specifically?

 

[Nidus]

what are you talking about dude

All bodybuilders get smaller during prep.

Who uses MT2 during prep, specifically?

Smaller by loosing fat and utilizing fat burners and other components, yes indeed.
MT2 is no secret so they get the tan they needed, so once the show tan is applied it looks even better. Seen plenty of bodybuilders do that, to slowly sneak in MT2 during prep to maintain a good tan and then simply look better on stage.

 

[AlexDavis43]

Smaller by loosing fat and utilizing fat burners and other components, yes indeed.
MT2 is no secret so they get the tan they needed, so once the show tan is applied it looks even better. Seen plenty of bodybuilders do that, to slowly sneak in MT2 during prep to maintain a good tan and then simply look better on stage.

OK all else aside: who are the bodybuilders sneaking in MT2, specifically? Any evidence of this or are you just guessing

I could be wrong

 

[Nidus]

OK all else aside: who are the bodybuilders sneaking in MT2, specifically? Any evidence of this or are you just guessing

I could be wrong

In germany, its quite common. One of the examples is Roman Fritz. He always stays on a maintenance dose during prep and towards the end he slowly increases it
According to himself he likes to have a slightly darker skin so that when tan is applied it looks better on stage and gives a little advantage compared to just applying tan
Tim Budesheim, also does that during the last 2-3 weeks of his prep but at really low doses. He is quite pale usually but during prep he gets a bit darker.

I can see it making sense to do that, tan can be a tricky thing and when it gives you a better look why not, also when deep in the prep MT2 might help with sex drive when its already nuked cause of the lack of food