Qingdao Sigma Chemical Co., Ltd (International, US, EU, Canada and Australia domestic

[nighthawkmuscle]

Tren plus tirz has been the easiest cut of my life. And I agree with what you said to the point I plan on keeping tirz in on my rebound and into the off-season at a very low dose for these exact reasons.

Would love to try tirz with trest. Trest shreds me like nothing else with so much energy but also makes you hungry as.

 

[AnTabolic73]

1. It's a mistake to think you'll reset "tolerance" to GLPs by taking a break. That's not how they work. They're hormones, not diet pills. Do you develop a tolerance to Testosterone? In fact, it seems stopping and restarting most often results in a weaker response in the future.

2. GLPs adjust the body's "set weight". At a stable dose, as your weight approaches that point, appetite suppression is reduced. If you gain weight, it will increase again. In order to increase appetite suppression once you've reached a weight where is weakens, you have to increase dose to push the "set weight" lower.

So which do you recommend: dropping to a low dose (2.5or5) during a bulk to reap benefit. Or dropping it completely during a bulk.

Also, if I were to drop it, when I do use it to cut again should I just start at the dose I last used or start at 2.5 and build like when I first start?

Also, when people switch glps because they feel it's not working. Is it just to regain appetite suppression? You're still reaping the benefits of glps even without feeling the appetite suppression?

 

[nighthawkmuscle]

Many buyers can't afford full kits at this concentrations, so no.

To put it politely, Fuck them. Would also prefer in higher concentrations. But I guess I get your stance.

 

[Merica1776]

1. It's a mistake to think you'll reset "tolerance" to GLPs by taking a break. That's not how they work. They're hormones, not diet pills. Do you develop a tolerance to Testosterone? In fact, it seems stopping and restarting most often results in a weaker response in the future.

2. GLPs adjust the body's "set weight". At a stable dose, as your weight approaches that point, appetite suppression is reduced. If you gain weight, it will increase again. In order to increase appetite suppression once you've reached a weight where is weakens, you have to increase dose to push the "set weight" lower.

Good info

 

[Ghoul]

So which do you recommend: dropping to a low dose (2.5or5) during a bulk to reap benefit. Or dropping it completely during a bulk.

Also, if I were to drop it, when I do use it to cut again should I just start at the dose I last used or start at 2.5 and build like when I first start?

Also, when people switch glps because they feel it's not working. Is it just to regain appetite suppression? You're still reaping the benefits of glps even without feeling the appetite suppression?

Personally, based on everything I've personally seen, experienced, and while not examined directly, anecdotally observed by researchers in studies and by practitioners in medical journal articles, using, then stopping GLP class meds, whether it's months or years, results in a weaker weight loss response for some reason.

The other benefits, to the heart, liver, vascular system, nerves, pancreas are independent of the weight loss aspect as those organs are all rich in GLP receptors and the benefits are the direct result of their activation.

I think staying on a low dose continuously, below the weight loss threshold, is the smartest way to use these for now, to avoid the risk of desensitization, and benefit from the long and growing list of potent health benefits.

When you want to lose weight, titrate the dose up over a few weeks, and drop back down.

As far as people switching to different GLPs because they think "it's stopped working" due to "tolerance" is overlaying their knowledge of other meds onto these.

How do we know there's no tolerance?

Because when used per the conventional protocol, once goal weight is reached, patients stay on a long term maintainance dose. Studies involving tens of thousands of users demonstrate that after 3 years at the same maintainance dose the overwhelming majority do not regain any weight. a few continue to lose, and even fewer gain a small amount. If tolerance was a thing, that wouldn't be the case and people would slowly return to baseline weight.

It's helpful to think of the thermostat analogy. These drugs lower the weight setting. Once that setting is reached, you no longer feel appetite suppression. If you gained weight you'd feel it again until you get back down to the "setting". By increasing the dose, the setting is lowered further, and appetite suppression would return until you get down to whatever the new level is. It's worth noting it takes 4 weeks at the new dose to reach the full potential of that dose. Sometimes one week after an increase it's barely felt, people increase again, and it's too much, so I like to wait 2 weeks after an adjustment to decide whether to increase again.

 

[Qingdao Sigma Chemicals]

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[rypeptideguy]

From what I researched for Tirz, shot every 5th - 6th day is optimal. I'm using for something else that's got nothing to do with fat loss, so I'm only taking 5mg each 5 days and not increasing it. I still notice appetite suppression and its been 6 weeks on it so far.

Honestly, at 5mg each 5th day, if I went onto even a semi clean diet, I'd be shedding weight!

I think as more research makes its way mainstream, people are going to realize that rapid fat loss is a side effect of overdosing GLP1's (Don't get me wrong, I'm not one to admonish anyone for high doses of anything, you do you) but I think the whole weight loss thing is really over shadowing just how beneficial LOW dose GLP1's can be for a whole range of things.

I also think off season low dose GLP1's will become mainstream in BB, low enough that they aren't interfering with being able to eat the calorie's to grow, yet still getting a whole heap of long term health benefit's from them. My thinking around it at this point is that it has the potential to act as protection for a host of negative health outcomes that can come from PED use.... But that's a very early opinion.

Combine daily Metformin with your low dose GLP1 shot and you may live forever.

 

[rypeptideguy]

Personally, based on everything I've personally seen, experienced, and while not examined directly, anecdotally observed by researchers in studies and by practitioners in medical journal articles, using, then stopping GLP class meds, whether it's months or years, results in a weaker weight loss response for some reason.

The other benefits, to the heart, liver, vascular system, nerves, pancreas are independent of the weight loss aspect as those organs are all rich in GLP receptors and the benefits are the direct result of their activation.

I think staying on a low dose continuously, below the weight loss threshold, is the smartest way to use these for now, to avoid the risk of desensitization, and benefit from the long and growing list of potent health benefits.

When you want to lose weight, titrate the dose up over a few weeks, and drop back down.

As far as people switching to different GLPs because they think "it's stopped working" due to "tolerance" is overlaying their knowledge of other meds onto these.

How do we know there's no tolerance?

Because when used per the conventional protocol, once goal weight is reached, patients stay on a long term maintainance dose. Studies involving tens of thousands of users demonstrate that after 3 years at the same maintainance dose the overwhelming majority do not regain any weight. a few continue to lose, and even fewer gain a small amount. If tolerance was a thing, that wouldn't be the case and people would slowly return to baseline weight.

It's helpful to think of the thermostat analogy. These drugs lower the weight setting. Once that setting is reached, you no longer feel appetite suppression. If you gained weight you'd feel it again until you get back down to the "setting". By increasing the dose, the setting is lowered further, and appetite suppression would return until you get down to whatever the new level is. It's worth noting it takes 4 weeks at the new dose to reach the full potential of that dose. Sometimes one week after an increase it's barely felt, people increase again, and it's too much, so I like to wait 2 weeks after an adjustment to decide whether to increase again.

I’ve seen the same results with 3mo on 2.5mg Tirz. I’ve plateaued. But when I want to drop to that new homeostasis weight I throw in 0.25 sema mid week which helps drop until I hit that new level.

I’ve read some info that a daily low dose Reta (.25 -.50mg) has been working very well during a cut. I have that on my radar once I see more studies about it. Especially since energy in the gym sucks when I throw Sema on top.

But Ghoul always makes a good point - if what your doing isn’t broken why fix it?

 

[Ghoul]

I’ve seen the same results with 3mo on 2.5mg Tirz. I’ve plateaued. But when I want to drop to that new homeostasis weight I throw in 0.25 sema mid week which helps drop until I hit that new level.

I’ve read some info that a daily low dose Reta (.25 -.50mg) has been working very well during a cut. I have that on my radar once I see more studies about it. Especially since energy in the gym sucks when I throw Sema on top.

But Ghoul always makes a good point - if what your doing isn’t broken why fix it?

My default position would be to stick with one until reaching the max conventional dose and only then switch, or in the case of Tirz, start adding a little Sema if not reaching the desired weight at 15mg.

The odds of not reaching goal weight with 2.4mg Sema or 15mg Tirz are pretty low, with most achieving it at lower dosages than that.

I tell friends either will help them lose weight more or less to the same degree, provide all the other health benefits, anti-addiction etc, with some specific considerations.

Sema for ultimate cost effectiveness, worth keeping in mind as 98%+ must stay on a GLP to maintain the weight loss.

Tirz for gentler sides (only a factor during titration period) and rapid reversal of fatty liver disease. At max dose 3x-4x more expensive than max dose Sema.

 

[LGOP528]

I’ve seen the same results with 3mo on 2.5mg Tirz. I’ve plateaued. But when I want to drop to that new homeostasis weight I throw in 0.25 sema mid week which helps drop until I hit that new level.

I’ve read some info that a daily low dose Reta (.25 -.50mg) has been working very well during a cut. I have that on my radar once I see more studies about it. Especially since energy in the gym sucks when I throw Sema on top.

But Ghoul always makes a good point - if what your doing isn’t broken why fix it?

I see little to no performance loss on Reta. It is pretty wild actually. During hard rounds of bjj on sema and triz, my cardio would be shot and I would be fighting off dry heaving. This has not happened with Reta. Obviously there is a limit but I have not found it yet. I would argue that their is something to be fixed if it is affecting your workouts.

 

[LGOP528]

If this is still an issue, maybe try CBD isolate. You get all the anxiolytic benefits and none of the psychoactive properties. I don't tolerate THC well at all, but CBD is great at anywhere from 30-200mg.

Occasionally, I'll have to speak in front of large groups or have contentious discussions. Beforehand I'll chug an energy drink and take 200mg CBD sublingual (in tincture form). It works a charm, I'm amped up, engaged, mentally present, but relaxed and most importantly, not a giant asshole.

I got through the degree so luckily I don’t have to deal with it anymore. I started with CBD but I have the other problem I tolerate drugs pretty well so it did not do much for me.

If I had to do it again, I would probably use NA-Semax. It really seems to keep me calm but also sharp.

 

[HB_22]

I see little to no performance loss on Reta. It is pretty wild actually. During hard rounds of bjj on sema and triz, my cardio would be shot and I would be fighting off dry heaving. This has not happened with Reta. Obviously there is a limit but I have not found it yet. I would argue that their is something to be fixed if it is affecting your workouts.

I feel like reta and survodutide are slightly catabol.