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If tirz or sema work well for you, then definitely don't mess with success.

But reta's "low single digit greater max weight loss" ends up being a what, 20-30% difference between it and tirz?

What I've noticed is that it doesn't have nearly the appetite suppression that tirz did, but it definitely does (for me) cause visceral fat loss and much greater vascularity.

How long do you expect to stay on it, or another GLP drug?

What do you expect to happen when you come off?
 
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Published 2 days ago at an international conference of nerve specialists:

TLDR: There's growing evidence GLP/GIPs (Tirz/Reta) protect and *regenerate* damaged nerves, throughout the body, including those responsible for causing cognitive decline, Alzheimer's and Parkinson's.

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What we do know about medications that work on the GIP and the GLP-1 receptors, particularly the GIP receptors, is that they affect neurons," said Russell.

He added that there is also the suggestion that these medications may help regenerate hippocampal neurons.

In addition, "there's evidence for drugs that affect the GIP receptor that they may be protective in animal models of parkinsonism or Alzheimer's disease. So, in other words, there's this idea that this isn't just a diabetic drug anymore it potentially, in fact, could affect diseases where there is neuronal degeneration," he added.

Commenting on the research for Medscape Medical News, Arun Krishnan, PhD, professor and head of the Neuromuscular Disease Research Group, University of New South Wales, and a neurologist at Prince of Wales Hospital in Sydney, Australia, said that these data are supported by recent work by his own group, which shows GLP-1 receptor agonists are highly effective treatments for improving nerve morphology, clinical symptoms, and nerve conduction parameters.

"This is a very exciting area of research as it suggests that diabetic peripheral neuropathy may be a treatable neuropathy, something that would have been considered unimaginable a decade ago. Given the enormous global burden of this condition, these treatments may have the potential to reduce neuropathy disability worldwide," said Krishnan.

He added that another paper from his team also suggests that these medications have a direct effect on peripheral nerves. "I don't think that it is due to weight loss or diabetic control. We have another manuscript, currently under review, that will support that argument," he added.

 
Then shut up already, mutual decision and nothing to do with you at all.

You missed the part where he said he “got two girlfriends to” have abortions. Nothing in that statement sounds like it was mutual or that they wanted to. Maybe it’s an argument over semantics, but unless he worded it wrong, it sounds gross.

You’re talking to a woman, and you’d be surprised how many times we are coerced, bullied, or told to abort by men who casually talk about how they “got” us to have abortions.

Iris was not replying to the procedure itself, but the way buddy seemed so flippant about getting women to abort.
 
I had constipation beyond just the gastric slowing and lower calls. Had to take Metamucil or stool softener pretty regularly. My brother did not tho ‍♂️
Thank you. Good to hear it is not just me. For me it was Retatrutide.Yes eventually it is also stool softener. Definitely side effects. I think 2-3 months is max this should be run.
 
In general, I prefer to minimize risk by not being an early adopter. By the time I used Sema (or Tirz), millions of "Patient years" of clinical experience had been established by their initial use for diabetes, and of course that was built on a 30 year history of earlier short acting GLPs.

Personally, while I respect adventurousness into new compounds (I worked my way through TIHKAL and PIHKAL decades ago if you know what those are), the question I'd be asking myself is "What are you trying to gain that offsets the additional risk, however small, of drugs we have significantly less experience with?"

So far all I've seen is possibly low single digit greater max weight loss potential, which I don't need. Slightly faster liver fat clearance which I don't need. So in my mind it's all additional risk, higher cost, and no benefit.

Again I think a lot of this may stem from thinking of these compounds like diet pills, and the "new ones" are "more effective" so I should use those.

Also, the primary driver in most of these is not to be "better", but to give each company a unique formulation they can patent and market in order to compete with Tirz.
I believe retatrutide is being developed by Eli Lilly, the same company that developed tirzepatide. I'm not sure how they plan to market it due to that. I doubt they would replace tirzepatide. It's only a few percent better at weight loss from what I've seen. Less food noise suppression but higher resting metabolic rate due to the glucagon action
 
I believe retatrutide is being developed by Eli Lilly, the same company that developed tirzepatide. I'm not sure how they plan to market it due to that. I doubt they would replace tirzepatide. It's only a few percent better at weight loss from what I've seen. Less food noise suppression but higher resting metabolic rate due to the glucagon action

Time will tell. You know how it goes: everyone wants results in 6 days, 6 weeks, 6 years? Millennials (no offense) are poisoned with instant gratification mentality.
 
Just received my primo from the group buy from qsc. First time ordering oils from them blue bottles what is confusion is that it is labeled peach oil. My peptides never come labeled is this normal?
Yup.
Advertising the stealth is genius.
Lol

Peach oil?
That’s probably anti stealth.
So stupid the customs agent gets mad

Like when the IRS finds out you’re playing games they go super saiyan
 
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