Weight will be regained with current GLPs. The thing about fat cells is that when you get them, you get them. They don't go anywhere. They just store fat or release them. Adipocytes don't die (except if one takes Adipotide.. but that is another kettle of fish)
Folks in their younger years will talk about eating like horses but not gaining weight. Well if the body keeps producing adipocytes, they are building a larger capacity "fat wallet" Eventually excess begins to accumulate in said wallets. The key strategy now is to make sure children never get the capacity to build "massive" wallets that will count against them in the future. For now, GLPS may be lifelong or at least less frequently contained in the maintenance phase. Remember these participants were not advised about how to wean off or taper. Recent studies have shown better weight control in those who taper off.
Then most importantly, there are newer drugs that actually target the liver more.
FYI there are at least 22 compounds varying from small molecules to peptides that are being researched.. Their activity varies from mitochondrial uncoupling (what DNP does, but safer) to long term appetite suppression to mechanisms similar to the existing GLPs.
There is a reason why Big Pharma is excited. The US is 'fat' Eventually folks will figure out a way to out medicate obesity. Especially with the increasing focus of Nutritional epi and weight management medicine being maintaining healthy body homeostasis/metabolism and not necessarily maintaining standard BMI
Last edited:
