Qingdao Sigma Chemical Co., Ltd (International, US, EU, Canada and Australia domestic

[Jeffholio5]

Better send me an email to tracy@sigmachemical.com.cn

my assistants can't help you that much.

I (Tracy in person) don't answer the sigma/whatsapp emails anymore, only customer service issues via tracy@sigmachemical.com.cn

That’s the email I used and received the response from. Doesn’t sound like you guys can help unfortunately since the vials have no markings on them and vial caps are random colors but i do appreciate you responding, my bad for not following the opening procedures to figure out which vial was what.

Would be nice in the future if you guys put the identifying numbers on the styrofoam that holds the vials or on the vials themselves. But now that I know the proper opening procedure I won’t make the same mistakes again.

 

[youwhat?]

Is this a good reason to use a vial per day? Immediately use after reconstitution seems it won’t be susceptible to the same aggregate issue,

Just add it to the list of reasons to use a vial a day

 

[NiMa]

That’s the email I used and received the response from. Doesn’t sound like you guys can help unfortunately since the vials have no markings on them and vial caps are random colors but i do appreciate you responding, my bad for not following the opening procedures to figure out which vial was what.

Would be nice in the future if you guys put the identifying numbers on the styrofoam that holds the vials or on the vials themselves. But now that I know the proper opening procedure I won’t make the same mistakes again.

Would be nice in the future you guy following the procedures and than all ist good.

 

[youwhat?]

Would be nice in the future you guy following the procedures and than all ist good.

Bro literally has said that 100x

 

[Ghoul]

Is this a good reason to use a vial per day? Immediately use after reconstitution seems it won’t be susceptible to the same aggregate issue,

Although I can't find it now, I read a study about aggregates in 7 different pharma rHGH formulations.

The GH that came with sterile water, not BAC, so were single dose / immediate use vials had the least aggregation and lowest rate of reported side effects.

Aggregates take time to form, an "incubation" period. The more time, the bigger they get. The larger they are, the more likely they are to cause immune reactions. That's not to say sides were definitely the result of aggregates, perhaps the lack of anti-aggregation ingredients in the immediate use formula HGH was the reason, but there's a lot of circumstantial evidence pointing to aggregates being responsible.

This applies to all peptides, by the way. The longer the chain, the more susceptible they are,

My preference is smaller dose vials of whatever peptide I'm using, so they spend the least amount of time reconstituted.

If it's a peptide used intermittently, like PT-141, hanging around for a long time, I'll filter the dose just before administration to reduce the number of large aggregates. A small reduction in potency from degradation is no big deal, but I'd rather keep the aggregates out to the extent practical.

 

[Jeffholio5]

Bro literally has said that 100x

I feel like at this point I’m mostly spamming this thread so I’m gonna step out for a while but I do appreciate everyone’s constructive feedback and assistance.

 

[Grey Spartan]

Aggregates take time to form, an "incubation" period. The more time, the bigger they get. The larger they are, the more likely they are to cause immune reactions.

Come on man. You need to tell us knuckle draggers "The incubation period for HGH is 7 days". So people like me won't order 36iu, add 3ml and take 2.4iu a day (that's 15 days a bottle for you math challenged). I know, I can take more iu's or filter but we expect more from you @Ghoul. lol

 

[Clover 0080]

I appreciate you checking man that helps me at least know the cap colors are pretty random so I’ll have to probably do some of my own testing to figure it out. I’ll probably at least figure out which ones are sustanon, mast p, and primo with the roid test kit if I’m lucky. the other two will just have to remain a mystery, I’ve ran ment before so hopefully I can figure out which one is ment from anecdotal testing then if I’m lucky I’ll have an idea which one is dhb at that point.

Lesson learned, learn from my mistakes guys don’t separate your oils from your boxes until you’re absolutely sure which one is what which and email qsc if you have questions before you do that. I may make another order sometime during a promo but I really wish there was some sort of standard for labeling the vials at qsc even if the labels were just random numbers or a QR code on the vials or caps would be awesome.

Damn I was looking forward to watching the steroid roulette play out.

 

[jasonsta]

I put 1ml of bacterio water per vial of 40ui, 3 vials which I put in a pen cartridge for a total of 120ui.
I take 6iu per day the cartridge lasts me 20 days without problem

 

[Ghoul]

Come on man. You need to tell us knuckle draggers "The incubation period for HGH is 7 days". So people like me won't order 36iu, add 3ml and take 2.4iu a day (that's 15 days a bottle for you math challenged). I know, I can take more iu's or filter but we expect more from you @Ghoul. lol

I find it comforting that the FDA's position on this is essentially (if I were writing for them):

"We know some, but not all the conditions that lead to aggregation. We don't know with certainty what the mechanisms are that lead to aggregate induced problems, but it's clear the more of that shit there is, especially the big fuckers >10um, the worse patient outcomes are, so do everything possible to minimize it."

Remember the old advice of "don't shake your peptide because it's 'fragile' and could break"? Jano did an experiment essentially disproving that.

It turns out there is something to it, but it takes time. The walls of conventional glass vials have "hot spots" of impurities that cause peptides to stick, become malformed, then aggregates "grow" on that spot. When shaken, those aggregates break loose, and now another peptide sticks to the same spot and begins growing another aggregate. So rough handling hastens aggregate formation.

And again, time is the enemy.

There are new high tech vials treated with a quartz like coating to prevent this adhesion (technically called "adsorption") and preserve peptides for longer.

Here's the same process(for the cartoon watchers here), but in a prefilled syringe where silicone lubricant is the glue making peptides stick and the aggregation process is worsened when they're knocked loose:

 

[Clyde1818]

U.S domestic have it good ! Canada dosen't even have test. No orals international

 

[bigtom343]

Well, it’s priced so cheap that you can viably do that as well. I just don’t want to graduate to the level of risk, myself. And don’t want to buy the equipment for brewing. So super cheap oils from QSC and filtering makes more sense for me.

I have always felt leery of ordering raws and brewing myself. I figure I am likely to get in more trouble with law enforcement by brewing raws than I am ordering finished oils. Brewing just seems like risky operation. Filtering dirt cheap vials seems like a better option for most imo.

I’m not sure if actually producing/manufacturing raws into oils carries a heavier sentence if caught. I love my gears but these wrists ain’t made for cuffs.

Filtering vials is also considered manufacturing in the eyes of the pigs

 

[Grey Spartan]

Filtering vials is also considered manufacturing in the eyes of the pigs

I want to call BS on this but I'm sure your right. I bet they would get you for distribution if you have more than three viles.

 

[Ghoul]

I want to call BS on this but I'm sure your right. I bet they would get you for distribution if you have more than three viles.

I mean they can charge you with whatever they want, but without direct evidence of sales it'd never stick.

Most states build their drug laws around the federal standards, and as of the new 2023 guidelines, fewer than 50 vials is a "level 6" crime, squarely in "personal use amount" territory. 1 gram of pot is "level 6".

 

[Qingdao Sigma Chemicals]

Two excipient ingredient examples from pharma:

Norditropin

histidine
poloxamer 188
phenol
mannitol

Genotropin

glycine
mannitol
metacresol

Histidine and metacresol are especially significant.

In short they create an environment that prevents peptides from breaking down and reforming into aggregates. I'm not going to go into the aggregate issue here, it's been discussed in depth elsewhere, but if you understand that dimer in HGH is bad, aggregate is "super dimer" that forms after reconstitution. At the least that makes some of the peptide ineffective, can induce side effects, and rarely, can trigger an immunity to HGH that makes it ineffective (happens in about 2% of HGH recipients).

On the other hand, you can be allergic to either of these ingredients, so in that sense, if Qs HGH only has mannitol, it's more "organic" and pure.

Metacresol is what’s responsible of the smell in geno and insulin pens

 

[Sampei]

Metacresol is what’s responsible of the smell in geno and insulin pens

I like that smell

 

[SpicyMeatball]

That’s the email I used and received the response from. Doesn’t sound like you guys can help unfortunately since the vials have no markings on them and vial caps are random colors but i do appreciate you responding, my bad for not following the opening procedures to figure out which vial was what.

Would be nice in the future if you guys put the identifying numbers on the styrofoam that holds the vials or on the vials themselves. But now that I know the proper opening procedure I won’t make the same mistakes again.

We like you despite the asking about cap colors which was quite the coup, don’t fuck it up by whining about the system.

 

[Bumpygooch]

Anyone else who’s ordered and received orals. Please advise if the packaging used for all orals is the same. Do they all read “20mg?” Several communications with Tracy and staff have been ambiguous. Ordered 3 orals, received 2, the quantity is accurate. However, they both look exactly the same and are all in the exact same packaging. For my own edification, prior to ingesting, I’d like reassurance that the both the compound and dosaging are what was ordered. The sku on one bag says “win5,” which I was told was winny. The other places only read “AF” as an identifier…..anadrol, perhaps(which is what was ordered). The anavar was excluded, even though the shipping charge wasn’t amended.

 

[Ghoul]

Metacresol is what’s responsible of the smell in geno and insulin pens

I don't know what the negative effects of those ingredients are, but generally preservatives are best avoided where possible. Pharma has to protect themselves from someone who never refrigerates the vial, is the one in a million who gets sick, and sues them. I'm pretty sure most here are smarter than that so maybe we're better off without those ingredients, and just treat reconstituted peptide vials like a container of milk.

 

[BazzBeat]

For me, the primo 200 always leaves a bit of lump. Nothing crazy, but not as smooth as EQ, mast, etc. DHB I haven't tried but yeah definitely gonna give bad PIP as far as I understand.

I used dhb (10 vial) . zero pip