MESO-Rx
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Qingdao Sigma Chemical Co., Ltd (International, US, EU, Canada and Australia domestic
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Trenbolonetax
Well-known Member
I shoot that IM specifically due to that. I use .5ml water. MOTS-C is the other one that does that for me.
Ghoul
Well-known Member
Normal for the compound. Make sure you're diluting to the correct proportions, and run through a 13mm .2um PES syringe filter to reduce or eliminate that reaction.
How about mast p?
Not sure as i am not interested in mast P. I will likely buy my oils elsewhere while the issue with the stocks persists.
2-3 days ago they told me my Mast P order during the last oils promo was out of stock. So they replaced it with Mast E. But 3 days later I asked for a tracking number and they sent me the tracking # for a different shipment (Reta 20). It makes me wonder if they really did have Mast E in stock. Ordering through QSC is such a goat rope.
The communication on WhatsApp has gone downhill hugely in the last two months for me.
Getting short answers and long waiting times for replies compared to what It was like before. The price of the Mast E and Primo 100 makes me come back but other than that the oils from other vendors are getting super close. For peptides QSC is king but oils I think maybe a diff vendor from now on.
I am also being told I cannot add 3ml kits of BAC water to my group buy order or I have to pay shipping lol seems a bit ridiculous.
MyNameIsJeff
Member
You know, I was skeptical about filtering peptides, but for this one, I might actually give it a try.
Ghoul
Well-known Member
The reason Menopur HMG vs the Repronex brand has so many fewer site reactions is because they filter out the "random proteins" that form large aggregates that trigger an immune response. I think you'll find filtering helps a lot.
The reason "random proteins" and degraded (broken chain) peptide "impurities" are a problem is because they've got lots of spots to adhere to each other forming aggregates. The original, intact peptide is typically not as "sticky".
Subcutaneously administered Menopur(R), a new highly purified human menopausal gonadotropin, causes significantly fewer injection site reactions than Repronex(R) in subjects undergoing in vitro fertilization - PMC
The safety and tolerability of a new highly purified, urine-derived human menopausal gonadotropin (hMG) preparation [Menopur(R)] was compared with a currently available hMG [Repronex (R)] in women undergoing in vitro fertilization (IVF). This was a ...
pmc.ncbi.nlm.nih.gov
MyNameIsJeff
Member
But this is about the purification of urine-derived HMG. QSC's is recombinant, so there should not be these types of impurities that require advanced filtering. Also, do you have a link for buying sterile, 4mm, 0.2 μm, PES filters?The reason Menopur HMG vs the Repronex brand has so many fewer site reactions is because they filter out the "random proteins" that form large aggregates that trigger an immune response. I think you'll find filtering helps a lot.
The reason "random proteins" and degraded (broken chain) peptide "impurities" are a problem is because they've got lots of spots to adhere to each other forming aggregates. The original, intact peptide is typically not as "sticky".
Subcutaneously administered Menopur(R), a new highly purified human menopausal gonadotropin, causes significantly fewer injection site reactions than Repronex(R) in subjects undergoing in vitro fertilization - PMC
The safety and tolerability of a new highly purified, urine-derived human menopausal gonadotropin (hMG) preparation [Menopur(R)] was compared with a currently available hMG [Repronex (R)] in women undergoing in vitro fertilization (IVF). This was a ...
Ghoul
Well-known Member
I'm sure QSC is paying for rHMG, and their supplier wouldn't take a shortcut by using the dirt cheap highly purified urine derived HMG from India, so I presume there are other impurities creating a side effect closely associated with the latter.
Other than a little bit of "ick" factor, they're equally effective anyway. I'm not sure if Jano's test distinguishes between the two. It looks to only be quantitative.
In any case, the filter will almost certainly reduce the site reaction by an order of magnitude or more. I've noticed the first post filtration dose of a site reaction inducing peptide is the best, and by a week later the site reaction from that vial returns to a degree (but still much better). I'm guessing that's because enough time has passed for more aggregation to take place. If I filter a single dose after this starts its back to being near reaction free, but per dose filtration can get expensive so you'll have to strike a balance.
I buy Pall from surplus science lab sources to get the supposedly better "Supor" PES material and they're still expensive, but this looks like a good source at a reasonable price (forget 4mm, the savings are next to nothing and they clog up fast when dealing with a "dirty" peptide). Holdup volume is only 2 units (.02ml) after you push 1ml of air through the filter to recover all the fluid you can:
DON'T get the type with the prefilter.
Sterile 0.2 μm PES Syringe Filters
Hydrophilic PES syringe filters with single or double-layer membrane. Pore sizes of 0.2μm. Diameter of 13mm/25mm/33mm with Luer lock. Sterile individually packed. Used for sterile filtration of protein solutions, cell culture media, and buffers.
shop.cobetter.com
Last edited:
curveball2025
New Member
I am also still waiting for a response from a couple of days ago. He will eventually answer.
Trenbolonetax
Well-known Member
Apparently I’m a knuckledragger who doesn’t care about the site reactions so I just do motsc and HMG in one 1ml syringe IM to delt lol probably don’t follow my lead on that
I am also a dirt bomb that just mixes stuff and doesn’t filter. No one should do what I do though, I never said I was smart
@Qingdao Sigma Chemicals is it possible to mix promos together in an order? For example domestic gh and tirz? Not a huge deal just curious
I doubt it man, they won't even allow me to add a few kits of 3ml BAC water without adding shipping cost .
MyNameIsJeff
Member
@Qingdao Sigma Chemicals Could you inquire with the raws supplier of your HMG as to possible reasons for the strong injection site reactions that users here see? As shown in the link provided by Ghoul, pharma-grade rHMG should not cause these reactions. Thanks!
Ghoul
Well-known Member
I realize the significance of this is going to be somewhat debateable, and despite the fact we talk about "peptides" as a uniform group of compounds they vary tremendously from one to another, so it's always hard to generalize about things like storage, or in this case, filtration and the the significance of immune reactions.
For me, if I'm getting PIP from a peptide, it's not the discomfort that concerns me, but what else may be going on as a result from that immune response.
While everyone wants definitive answers, the only thing we (and the FDA and Pharma) know for sure is the range of possibilities of injecting some deformed protein is from nothing to catastrophic. This risk is somewhat limited in pharma produced peptides manufactured and reconstituted under controlled conditions. They can guess what "worst case" scenario might be by running a simulation of all the ways a protein could break down and reform, and how strongly of an immune reaction those could induce.
We don't have anything like those controlled conditions with UGL compounds reconstituted with random BACs, at random PHs, and random concentrations (the last one is ridiculous, every peptide should have a clear "standard" for dilution ratio).
If I'm getting a site reaction, that's a warning sign as far as I'm concerned, and for those peptides especially, it's worth 5 minutes and $1 to filter the vial to reduce my exposure to some randomly formed protein that no one has ever considered as possibly being injected into a human.
Spaceman Spiff
Well-known Member
For the record, I don't get anything out of any testing and posting for QSC
I share my results for everyone. I want more people to homebrew. Control your oils you use.
I have always been happy with the raws I have received. Also peptides
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