The one thing I see glossed over time and time again in discussions about this class of drugs is that they were NOT designed to reduce appetite. Yet appetite reduction is seemingly the only topic on the table. Appetite reduction is a side effect of this class of drugs which were designed to reduce blood glucose/ A1C. Incretin mimetics work by switching on insulin and suppressing glucagon to control blood glucose. Ostensibly quite simple. Some people don't even experience a reduction in hunger. They simply don't "suffer" that particular side effect of these drugs.
It pisses me off to no end when people say, "______ stopped working for me!" Fill in the blank with Tirz, sema, reta, whatever. No, unless you're measuring your blood glucose on a regular basis and noted an increase, the drug is absolutely still working. Not to mention 80% of those people aren't even on the full recommended dose.
So, to answer your question, it depends on what the desired results are. There exists a multitude of reasons for which one would use these drugs. The original question was in reference to benefits outside of appetite reduction. In my opinion, the larger the dose the more benefits you will experience. But as with, say, testosterone, that dose will vary per individual.
I've used nearly 5mg/ week of sema and currently use 22mg/ week of tirz. I don't experience the same negative effects that some people report with any dose of either of these drugs. I can eat as much or as little as I want and I poop just fine. I'll probably step up to 25mg soon. I'm personally pushing to see what magic can happen for me outside of appetite control. But I won't go into that here.
The pharmaceutical companies have created dosing protocols that work for a majority of people. Use those as a guide but not a limit.
As with any other performance enhancing drug, one should be monitoring blood work and vitals and noting how they feel with each escalation in dose.
