Qingdao Sigma Chemical Co., Ltd (International, US, EU, Canada and Australia domestic

[kingtung]

Here we go again...

No his on the right track bro. The reasons to why generic doesn't 'feel' like pharma (bloat, extreme lethargy etc)

 

[Qingdao Sigma Chemicals]

@Qingdao Sigma Chemicals What color are the caps on the Test-C 250mg vials from the Test Apocalypse Promo supposed to be? I was expecting purple based upon the link to the Jano on the price list, but I received blue cap vials which the price list shows as being Test-E.

We don’t have color of tops for oils that matchs the lab tests

 

[BP_6]

No his on the right track bro. The reasons to why generic doesn't 'feel' like pharma (bloat, extreme lethargy etc)

That is very subjective. Many people have also claimed they notice no difference between generic and pharm grade. The only way to confirm this would to be to do a blind study and give some people pharm grade and others generic and then document the results.

 

[Qingdao Sigma Chemicals]

Because unless I'm mistaken, haven't we seen 99% HGH results from his lab?

Yes and it’s 2 pages earlier.
It didn’t cost us more to produce it.
Been tested 99% wasn’t a reason for me to act greedy and sell it at higher prices.
HGH production process has always been the same.
Same cost.
Either it tests 96% or 99%.
What can be interesting is to send some hgh raw materials for testing and see what the purity looks like before the freeze drying.

 

[ThePepBrother]

We don’t have color of tops for oils that matchs the lab tests

Okay, I was going off the pictures in the Janos that are linked to your price list for the products. Also, there are no SKU codes on any of the boxes I received for me to use to verify with your assistants that the vials I received are what I ordered.

 

[max187]

We don’t send confirmation email.
It means your order is processed

Okay no problem, I sent the hash and the payment was received and accepted. I emailed Nia asking for tracking information and this is what she replied. I've never had this happen before in my 20+ orders with QSC.

 

[kingtung]

That is very subjective. Many people have also claimed they notice no difference between generic and pharm grade. The only way to confirm this would to be to do a blind study and give some people pharm grade and others generic and then document the results.

Read my image.

Generic can produce good igf, its the '5%' that can cause people issues.

Qindao, if production same why is it some batches score 95 some 99? Shouldn't it as your saying, same cost and process all theoritcally be same numbers?

 

[bighunanballs]

Here we go again...

At least ol dude is offering research backed opinions as to why we see such anecdotal spread of efficacy between pharma and UGL HGH. A much more clearly laid out hypothesis backed with links to studies compared to the nonsense Kurt Havens and other "ped educators" spread about UGL vs Pharma hgh. "It's the polymers in ugl hgh", "the molecular weight of UGL hgh is different than the MW of pharma"

 

[Ghoul]

Here we go again...

I decided some time ago I'm not the Headmaster of "Ghoul's Academy of Wayward Knuckledraggers", so I'm reluctant to waste my time with basic education on a given topic, and only take the time to respond with explanations to questions presented in a sincere respectful way.

Since you haven't been a complete asshole, I'll give you the benefit of the doubt,

You have a fundamental misunderstanding of how the threat of immunogenicity is measured, and managed.

The study you quoted does not mean "immunogenicity is not a problem with Tirzapatide no matter how high immunogenicity levels get, Hooray!"

It means "Using the formulation we intend to sell at retail, delivered in these specific pens, at these doses, injected in these 3 areas, ONCE A WEEK, over this period of time, in patients matching the demographics of the selected subjects, the measured level of immunogenicity that developed did not rise to a clinically significant level."

If ANY of those factors change, like the prescribed injection frequency or the plastic used to make the pens, they MUST demonstrate to the FDA that immunogenicity won't increase to a level that threatens health.

It does NOT MEAN "And if we let our manufacturing standards decline inducing higher levels of impurities, synthesized instead of of using recombinant methods to produce Tirz, used higher concentrations, switched to daily injections, left it unrefrigerated for months, let subjects hop on and off at will to maximize "re-exposure events" immunogenicity won't be a problem.

UGL tirz is not recombinant, it's synthesized.

It's not supplied via a cold chain in high quality, particulate free containers.

It's not reconstituted with regard to any specific PH to prevent immunogenic inducing aggregates.

It's not very likely to have a 2 year shelf life in reconstituted form like pharma is, because UGL is "sloppy", allowing for all these factors to degrade it into forms that are known to induce higher levels of immunogenicity.

Here are the in vitro immune responses to pharma GLPs vs 2 compounding pharmacy GLPs, who are using synthesized APIs and excipients that differ from the pharma formulation. Do you think a 200x stronger immune reaction will have the same "non clinically significant" impact the ultra-low immunogenicity pharma products do?

Pharma GLP immune response (left side of each chart vs Compounder GLPs (two on the right of each chart).


Even in the case of pharma, some GLPs result in significant enough immunogenicity over 6 months or a year diabetics start to see their blood glucose get out of control because they develop immunity to the proteins, and have to stop using the drugs. 200x stronger reactions are certain to bring that on faster and with more severe effects.

All I'm suggesting is doing what you can to minimize the possibility. Take whatever action you're willing to and find reasonable. Notice that after .2um filtration, one of the compounder GLP showed an 80% lower immune response. Would you consider filtering an unnecessary waste of effort?

You're suggesting no need to bother because it can't possibly be a problem. You likely won't be satisfied without a trial intentionally trying to induce immunogenicity in subjects, which would never be allowed, The FDA specifically expresses great concern that trial subjects not be exposed to immunogenic risks, and so the unpublished computer simulations, in vitro tests, and animal studies are performed, then adjustments are made, and only once the FDA is very confident a particular protocol won't be an issue will trials on human subjects be allowed.

We are the *trial subjects* for a whole host of experiments with these unregulated, largely untested novel compounds without the benefit of any immunogenicity predicative testing to ensure it won't impact our health.

Individuals can decide which way is prudent for themselves.

 

[Xiaoxiong]

@Qingdao Sigma Chemicals - I ordered some winstrol 25mg with Black Friday promo.. the Jano report has oblong tablets, the ones I received are round, can you confirm that is correct?

@Qingdao Sigma Chemicals - can you confirm the current winstrol tabs are round and not oblong?

 

[Qingdao Sigma Chemicals]

@Qingdao Sigma Chemicals - can you confirm the current winstrol tabs are round and not oblong?

Yes there have been a round tabs restock

 

[GearUnit]

Got my packed after 15days to EU.
It is better packed and label from another china source.

But for now I am happy.

Thanks QSC

 

[bighunanballs]

This is interesting, because "High Molecular Weight" (HMW) proteins can induce side effects, largely through immunogenic reactions.

However, HMWs can either be longer than intended protein chains that aren't removed during the recombinant production process, which would show up in purity tests, or aggregates, which primarily form after reconstitution.

We can see there's been an evolution in the quality of HGH from years ago, when zero dimer was a rarity, for instance. It's important to recognize what was true a decade ago is not necessarily true today.

Since we're seeing 99%+ purity tests on UGL hGH, I'd say the remaining difference between Pharma and UGL is the lack of aggregate formation prevention through the careless choice of excipients (especially PH control), substandard BAC water, excess concentration of reconstituted product, contaminated containers providing aggregate "seeds" that become the nuclei for aggregates, and general poor handling by vendors and end users.

This is unlike the differences between pharma GLPs and UGL GLPs, since pharma is recombinant and UGL is synthesized, regardless of the purity achieved, or the lack of aggregation(though this is also an issue for UGL for the same reasons as above), synthesized proteins appear as more "foreign" to the immune system than recombinant produced proteins and trigger stronger immune responses.

At the end of the day all this points to the fact that if you want to get as close to "pharma" results as you can, use what's in your control to mimic pharma.

Start with the purest HGH / peptide you can source.

Use pharma grade BAC

Reconstitute to the proper minimum dilution ratio.

Filter (even better if done per dose aka "bedside filtration" in medical terms, just before administration, but this can be a pain in the ass, though there are ways to make it more practical).

Transfer to a container that's been certified particulate free by an FDA facility (these are cheap).

Protect from heat, impact, and light by spending the extra dime on amber glass(thanks @Clover 0080) .

Try to use lower dose vials to minimize the time your peptide/HGH is in reconstituted form.

Looks like serostim says .5-1ml bac water per 4,5 & 6mg vial. Pretty big spread there. You could theoretically match this with QSC 36iu kits with only 1ml bac water

 

[bullysticks235]

Yes there have been a round tabs restock

Check your DMs.

Received order but missing quite a bit! Again, unable to reach anyone regarding the issue.

 

[Roidster]

@Qingdao Sigma Chemicals still waiting for an answer for the missing kit, pls check your email

 

[Qingdao Sigma Chemicals]

Check your DMs.

Received order but missing quite a bit! Again, unable to reach anyone regarding the issue.

In 99% of cases when someone tells me he’s missing something, he is just not aware of the other trackings, many orders are shipped with multiples packs including dom and int.

Please if you have any customer service issue send to tracy@sigmachemical.com.cn

Today we took a day off, but tomorrow we resume replies to emails and whatsapp