Qingdao Sigma Chemical Co., Ltd (International, US, EU, Canada and Australia domestic

[Weedup]

Michael O. Frederick, Raymond A. Boyse, Timothy M. Braden, Joel R. Calvin, Bradley M. Campbell, Shujauddin M. Changi, Stephanie R. Coffin, Carmel Condon, Olivia Gowran, Jennifer McClary Groh, Stephen R. Groskreutz, Zachary D. Harms, Ashley A. Humenik, Neil J. Kallman, Nicholas D. Klitzing, Michael E. Kopach, Juliana K. Kretsinger, Gordon R. Lambertus, Jeffrey T. Lampert, Laura M. Maguire, Humphrey A. Moynihan, Nessa S. Mullane, John D. Murphy, Marie E. O’Mahony, Rachel N. Richey, Kevin D. Seibert, Richard D. Spencer, Mark A. Strege, Nil Tandogan, Frank L. Torres Torres, Sergey V. Tsukanov, Han Xia,

Kilogram-Scale GMP Manufacture of Tirzepatide Using a Hybrid SPPS/LPPS Approach with Continuous Manufacturing,

Organic Process Research & Development,
Volume 25, Issue 7,
2021,
Pages 1628-1636,
ISSN 1083-6160,

Abstract:

ABSTRACT

The large-scale manufacture of complex synthetic peptides is challenging due to many factors such as manufacturing risk (including failed product specifications) as well as processes that are often low in both yield and overall purity. To overcome these liabilities, a hybrid solid-phase peptide synthesis/liquid-phase peptide synthesis (SPPS/LPPS) approach was developed for the synthesis of tirzepatide. Continuous manufacturing and real-time analytical monitoring ensured the production of high-quality material, while nanofiltration provided intermediate purification without difficult precipitations. Implementation of the strategy worked very well, resulting in a robust process with high yields and purity.

 

[TestosTyrone]

View attachment 307055

QSC domestic delivery. Primo 100… My mailman is going to start wondering why my boxes arrive covered in oil.

Just filter it bro

 

[Kiraa710]

I used to ship soda and beverages professionally.

We eventually concluded that a 330mL can of soda, bubble wrapped in a double walled box from Uline, packed with clear packing tape and filled with packing paper had almost 1/3 a chance of busting open.

If they can do that to metal that is bubble wrapped, padded and inside a reinforced box, I have trouble making any kind of excuse for vendors here shipping illegal goods IN GLASS.

 

[Grey Spartan]

Just filter it bro

Were your 80mg Oxandrolone round?

 

[TestosTyrone]

Were your 80mg Oxandrolone round?

They never sent me any lmao so I got a refund and found a better deal on a thousand 25mg round tablets

 

[Streetfighter V4]

When I use this blend I take first my dose of the mix then add 0.2/0.5ml of test p.
It literally feels better almost no pip

If you are running test also just mix it.
Problem usually solved.

What do u mean, its test tren mast mix, if i add test it’ll be too much which i dont want, i might add 0.5 npp, no harm in that

 

[TestyisBesty]

What do u mean, its test tren mast mix, if i add test it’ll be too much which i dont want, i might add 0.5 npp, no harm in that

It’s been posted all over the thread that it causes pip and some fatigue.

Buy separate and pin.

 

[5thGen]

FYI… post office keeps notes.. you also said 2nd time in 8weeks.. it’s been noted for sure. You better take a long break…

 

[BamaCrazy]

FYI… post office keeps notes.. you also said 2nd time in 8weeks.. it’s been noted for sure. You better take a long break…

Unfortunately I have one more order of oils coming from SSA that they’ve been delaying forever. That’ll be the last for a while.

 

[bigMoJo]

This is the 2nd time in 8 weeks. GA got me last time. Domestic also. They managed to break the plastic case this time.

Basically, all your packs. Your postal worker has a problem with you bro. He's just making you suffer through "death by a thousand cuts" before the big LE "finale."

 

[AlmightyAlpha]

These last orders from QSC have been the slowest. I ordered the HGH kit promo still waiting, test oil promo, still waiting, black Friday still waiting, tirzepatide order still waiting... And they were placed on Nov 22 and barely started moving 12/7

 

[Ghoul]

These last orders from QSC have been the slowest.

Don't give up. They can always be even slower next time.

 

[AlmightyAlpha]

Don't give up. They can always be even slower next time.

I mean there's movement finally but damn... 21 days just to get the party started is slow slow.

 

[5thGen]

2nd half of my BF local promo landed , not 1 of the DHB was crashed at all? I can’t believe it , especially this time of year and the commute time ? Well done,, tabs were nicely done and very easy to tell apart , winny and dball… and the 20mg Bpc is very good , actually jano test lists 22mg per vial.. that was the best deal ever .. ty

 

[Deezznutzz]

Received my kits from the oil promo today. Where are the sku numbers? Not seeing anything. Someone PM me to keep things more Ospec. What color tops are the Cyp kits? Thanks.

 

[Deezznutzz]

You’re lucky that none were broken and that you actually got a barcode/sku on at least one of your products. My Test-C arrived intact in the padded cosmetics boxes. They had no barcode/sku on any of the boxes, and had the same blue caps as your vials. Every vial was severely crashed (but fixable with guidance from @Ghoul). Tracy’s assistant’s reply to my request for verification from photos I sent was that I did get Test-C, but I have no idea how she came to that conclusion because there were no barcodes/skus on anything. Tracy’s response was not to rely on cap colors. I guess there’s no real way of knowing what I got unless I send a sample out for testing.

Same here. Dark blue caps everything is crashed. Not a big deal. Just hope its test C because mine is crystal clear like mast. No tint at all.

 

[Rippidy Dippidy]

Trackings are available for most of canadian orders.

negative here.

 

[Rippidy Dippidy]

What color tops is the 10mg triz promo?

Also does triz cause these symptoms? Stiffness in neck and back, and skin pain NOT surrounding the injection site. Coworker has some weird symptoms. She doesn’t take any other medications besides birth control, doesn’t smoke drink or use recreational drugs. This was about 24hrs after injection. Absolutely no redness or anything near the injection site. I gave her 5mg

@Ghoul

Usually morons who have no clue what they're doing will blame a head ache on the new thing they just injected.
Sounds like a case of thinking too much.

 

[Rippidy Dippidy]

Some people have skin symptoms like allodynia in response to higher doses of GLP-1s. People have reported this while on Tirz, on the 7.2 Sema (from the clinical trials) and on Reta too

7.2mg sema ? you serious? probably losing weight from the amount they're profusely vomiting

 

[Rippidy Dippidy]

Yes, to clarify for everyone that is exactly the situation. She was moving from the 2.4 wagovy pens and ghoul suggested 10 based on that.

Did the 2.4 pens work? if she's still fat on them she's a lost cause and give up before it's "your fault."
Does she know she can't continue stuffing her face and a pen comes into her life and immediately makes her fat disappear ?
I got sick of trying to help people myself, "i eat like 1 meal a day and its like 1000 calories i promise and i don't lose weight" - okay i need you to track your calories. "that's too much work"
lots of these clowns want to eat whatever they want whenever they want and think a magical pen is gonna erase them hitting the drive thru everyday. Makes me fucking sick