Ghoul
Well-known Member
A PES filter.
What the drop tests on HGH found was loss of GH by adhesion to the glass walls of the vial, which had to be recovered with a chemical soak overnight to measure. Pre-reconstituted commercial formulations include Polyaxamer 188 to prevent this "stickyness" and loss of the protein, which happens over time even without shock, but the drop made it worse.
The bigger effect from a drop is the sudden increase in aggregate formation. Initially, the aggregates were too small to identify with regular chromatography "size exclusion" techniques, but over time. they act as seeds and as more and more GH attaches to them, more GH is lost, and as they become larger, the odds of causing immune reactions increase.
So the "loss" from the drop isn't much, after 1 drop the total lost to adhesion to the glass went from 7% to 10% of a single iu (this was a 5iu/1ml vial, the higher the concentration, the worse this loss would be) but starting the "fire" of aggregation is the bigger issue, and filtering will help rid the HGH of the largest, most problematic aggregates.
None of this has anything to do with QSC HGH in particular. And the addition of polyaxamer 188 causes some degradation itself, so the pharma companies are striking a balance of a little degradation to prevent greater loss from sticking to the glass over time.
As usual, the faster you can use up a vial after reconstitution, the better., and filtering always help minimize unwanted immune reactions. Pharma BAC, if you can get it, helps too.
