Qingdao Sigma Chemical Co., Ltd (International, US, EU, Canada and Australia domestic

A PES filter.

What the drop tests on HGH found was loss of GH by adhesion to the glass walls of the vial, which had to be recovered with a chemical soak overnight to measure. Pre-reconstituted commercial formulations include Polyaxamer 188 to prevent this "stickyness" and loss of the protein, which happens over time even without shock, but the drop made it worse.

The bigger effect from a drop is the sudden increase in aggregate formation. Initially, the aggregates were too small to identify with regular chromatography "size exclusion" techniques, but over time. they act as seeds and as more and more GH attaches to them, more GH is lost, and as they become larger, the odds of causing immune reactions increase.

So the "loss" from the drop isn't much, after 1 drop the total lost to adhesion to the glass went from 7% to 10% of a single iu (this was a 5iu/1ml vial, the higher the concentration, the worse this loss would be) but starting the "fire" of aggregation is the bigger issue, and filtering will help rid the HGH of the largest, most problematic aggregates.

None of this has anything to do with QSC HGH in particular. And the addition of polyaxamer 188 causes some degradation itself, so the pharma companies are striking a balance of a little degradation to prevent greater loss from sticking to the glass over time.

As usual, the faster you can use up a vial after reconstitution, the better., and filtering always help minimize unwanted immune reactions. Pharma BAC, if you can get it, helps too.
Thanks for the detailed breakdown—this really cleared up a lot for me. I didn’t realize aggregate formation was such a significant long-term issue, even beyond the initial protein loss from adhesion. It’s wild how it can snowball and increase the risk of immune reactions.

I’ll definitely handle reconstituted vials more carefully and start filtering as a precaution. Better safe than sorry, and I’ll use up that vial as quickly as possible. Honestly, some of these sources should have someone like you as an advisor for testing and product stability. If you hadn’t questioned that Jano test, I wouldn’t have known any better.
 
Hey just got the NPP, great packaging and short time for international thank you! But QSC really I paid 170 for CARGI now you promo for 90? I need to remember that for next year. Again, thanks for the speed and excellent packaging.
 
Hey there, just paid for an order via email after the rep sent me the BTC address/amount. Trying to reply to her with transaction hash and every reply keeps getting bounced back to me via Proton's Mail Daemon saying it was returned to sender because it was caught in QSC's spam filter.

Tracy can you help me get my email to Nia so my payment doesn't get lost? Thank you

Update: one of them finally got through when i sent a fresh email not as a reply. fixed it.
 
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Hey there, just paid for an order via email after the rep sent me the BTC address/amount. Trying to reply to her with transaction hash and every reply keeps getting bounced back to me via Proton's Mail Daemon saying it was returned to sender because it was caught in QSC's spam filter.

Tracy can you help me get my email to Nia so my payment doesn't get lost? Thank you

Update: one of them finally got through when i sent a fresh email not as a reply. fixed it.
Happens all the time. I think it’s an issue with a file that’s attached to the email.
 
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