Qingdao Sigma Chemical Co., Ltd (International, US, EU, Canada and Australia domestic

[thecmorgan]

l

Sema 7.2mg and CagriSema trials both ended up being failures(hitting Novo's stock price) , despite early promising results,

Why do you think the sema trial was a failure? The data that was released last month looked good for the 7.2mg trial. Just wondering If I missed something.

STEP UP Trial Shows Semaglutide 7.2 mg Achieves Superior Weight Loss vs. 2.4 mg, Placebo | Applied Clinical Trials Online

Semaglutide 7.2 mg significantly outperformed semaglutide 2.4 mg and placebo with a 20.7% average reduction in weight and a comparable safety and tolerability profile, further establishing its efficacy in obesity treatment.

www.appliedclinicaltrialsonline.com

The randomized, double-blinded, parallel-group, superiority phase 3 STEP UP trial (ClinicalTrials.gov Identifier: NCT05646706) enrolled 1407 adults aged 18 years and older with a body mass index of at least 30kg/m2 and without diabetes. Study participants were randomly assigned to receive subcutaneous semaglutide 7.2 mg, semaglutide 2.4 mg, or placebo once weekly; all treatments were in conjunction with lifestyle interventions.

Results based on the trial product estimand (treatment effect if all people adhered to treatment) showed semaglutide 7.2 mg-treated patients achieved a superior weight loss of 20.7% after 72 weeks compared with a weight loss of 17.5% and 2.4% in those treated with semaglutide 2.4 mg and placebo, respectively. Notably, 33.2% of patients who received semaglutide 7.2 mg had a weight loss of at least 25% compared with 16.7% with semaglutide 2.4 mg and 0.0% with placebo.

Findings from the treatment policy estimand (treatment effect regardless of treatment adherence) demonstrated similar results, with the semaglutide 7.2 mg group achieving a superior weight loss of 18.7% vs 15.6% and 3.9% for the semaglutide 2.4 mg and placebo groups, respectively.

Treatment with semaglutide 7.2mg was safe and well-tolerated, with the most common adverse events reported being mild to moderate gastrointestinal issues.

 

[Juiced_lizard]

My vision has definitely changed.
Background: Taking tirz for about 6 months. Initially from Henry Meds (compounding Rx) then over to QSC. Down 30lbs, 230-200lbs so far. Never diabetic. No high BP issues ever or other conditions that might mess up my vision.
Had to go out and get a new eyeglass Rx last week.
Told doc about weight loss/tirz, and he said "yeah, that's probably why. we're seeing vision changes with people on GLPs"
He attributed it to "less inflammation and less physical pressure on the eyes."
Guess we'll see if this is a problem or not down the road. Maybe just fat people getting unfat vs some new side effect of the drugs. I'll let you guys know if I go blind.

did/do you monitor glucose? Do you go hypoglycemic regularly?

 

[Thequadfather]

i've had Fantastic success with bpc157, ymmv,

My wife had great results with oral BPC for her gut issues. Me using it for injury repair feels like a placebo, but I may just be underdosing. I have been using it for three months post-op for a hernia repair, and I feel no difference compared to natural healing.

 

[Ghoul]

Why do you think the sema trial was a failure? The data that was released last month looked good for the 7.2mg trial. Just wondering If I missed something.

STEP UP Trial Shows Semaglutide 7.2 mg Achieves Superior Weight Loss vs. 2.4 mg, Placebo | Applied Clinical Trials Online

Semaglutide 7.2 mg significantly outperformed semaglutide 2.4 mg and placebo with a 20.7% average reduction in weight and a comparable safety and tolerability profile, further establishing its efficacy in obesity treatment.

www.appliedclinicaltrialsonline.com

The randomized, double-blinded, parallel-group, superiority phase 3 STEP UP trial (ClinicalTrials.gov Identifier: NCT05646706) enrolled 1407 adults aged 18 years and older with a body mass index of at least 30kg/m2 and without diabetes. Study participants were randomly assigned to receive subcutaneous semaglutide 7.2 mg, semaglutide 2.4 mg, or placebo once weekly; all treatments were in conjunction with lifestyle interventions.

Results based on the trial product estimand (treatment effect if all people adhered to treatment) showed semaglutide 7.2 mg-treated patients achieved a superior weight loss of 20.7% after 72 weeks compared with a weight loss of 17.5% and 2.4% in those treated with semaglutide 2.4 mg and placebo, respectively. Notably, 33.2% of patients who received semaglutide 7.2 mg had a weight loss of at least 25% compared with 16.7% with semaglutide 2.4 mg and 0.0% with placebo.

Findings from the treatment policy estimand (treatment effect regardless of treatment adherence) demonstrated similar results, with the semaglutide 7.2 mg group achieving a superior weight loss of 18.7% vs 15.6% and 3.9% for the semaglutide 2.4 mg and placebo groups, respectively.

Treatment with semaglutide 7.2mg was safe and well-tolerated, with the most common adverse events reported being mild to moderate gastrointestinal issues.

"Failed" from a business perspective.

Both of these trials were intended to give Novo a product to compete with Eli Lilly. Neither did.

CagriSema failed to reach its target and underperformed Reta results,

Novo Nordisk stock crashes after CagriSema misses phase 3 weight-loss goal

A phase 3 trial of Novo Nordisk’s next-generation obesity prospect CagriSema has failed to achieve the level of weight loss targeted by executives, prompting investors to wipe 19% off the | A phase 3 trial of Novo Nordisk’s next-generation obesity prospect CagriSema has failed to achieve the...

www.fiercebiotech.com

While it's good to know much higher doses of Sema are safe, triple the dose for a 2.5% median greater weight loss vs 2.4mg, along with a disproportionate increase in sides is nothing to get excited about. What doctor would prescribe this over Tirz?

All they can do with these is drop the price, and say "May not be as good as Zepbound/Reta but it's a better value.", if they do market either.

 

[Dirthand]

What the f dude?! My friends don’t give me free shit, let alone top quality stuff like that.
I need to meet this girl.

Shit i've never met her, but she is a good friend.. People on here and discord (in my experience ) give each other shit all the time for nothing... just out of human kindness and out of privacy or humility dont say much about it!! Although I am a smartass publicly, privately i am a pretty ok dude which has warranted me some pretty amazing online friends on this board and discord. It's fucking amazing the kindness and comradery that goes on behind the scenes here without any drama or negativity . It truly warms my heart.. now fuck.off
Peace
D

 

[glpfun]

Shit i've never met her, but she is a good friend.. People on here and discord (in my experience ) give each other shit all the time for nothing... just out of human kindness and out of privacy or humility dont say much about it!! Although I am a smartass publicly, privately i am a pretty ok dude which has warranted me some pretty amazing online friends on this board and discord. It's fucking amazing the kindness and comradery that goes on behind the scenes here without any drama or negativity . It truly warms my heart.. now fuck.off
Peace
D

I’ve seen a lot of begging for steroids on discord and people sending them stuff lmao

 

[Ateam2023]

My wife had great results with oral BPC for her gut issues. Me using it for injury repair feels like a placebo, but I may just be underdosing. I have been using it for three months post-op for a hernia repair, and I feel no difference compared to natural healing.

if your doing less than 1 mg per dose of injectable bpc157 , then yes you are under dosing imho,, ive used up to 5 mg a day split in several injections and have had amazing results "aiding" in a severe tennis/golfers elbow injury,,

 

[Here2Learn]

My wife had great results with oral BPC for her gut issues. Me using it for injury repair feels like a placebo, but I may just be underdosing. I have been using it for three months post-op for a hernia repair, and I feel no difference compared to natural healing.

Oral is great for gut but not for healing other areas from what I’ve read.

 

[Dirthand]

I’ve seen a lot of begging for steroids on discord and people sending them stuff lmao

Different situation , i generally only use discord for PM.. my message had nothing to do.with desperate begging peices of shit.... dont make it out to be....

 

[mok4315]

My wife had great results with oral BPC for her gut issues. Me using it for injury repair feels like a placebo, but I may just be underdosing. I have been using it for three months post-op for a hernia repair, and I feel no difference compared to natural healing.

if your doing less than 1 mg per dose of injectable bpc157 , then yes you are under dosing imho,, ive used up to 5 mg a day split in several injections and have had amazing results "aiding" in a severe tennis/golfers elbow injury,,

BPC did nothing for me. I went up to 2mg/day, though maybe a higher dosage would’ve been worth it. I was trying to decrease the chronic pain from an overuse injury after 25 years of martial arts, but gave up on BPC after 5 months. Anecdotally though it’s helping people a lot with recent injuries, even if not so much with chronic injuries.

 

[Thequadfather]

if your doing less than 1 mg per dose of injectable bpc157 , then yes you are under dosing imho,, ive used up to 5 mg a day split in several injections and have had amazing results "aiding" in a severe tennis/golfers elbow injury,,

I do 2mg daily.

 

[Dirthand]

after 25 years of martial arts

I told yall GI Jane badass!!
Have tou tried tb500 (tb4)?? Sure you have.....

 

[Trailmixed]

Have any of y'all tried the mix of BPC/TB500/GHK-Cu?

 

[Dirthand]

Have any of y'all tried the mix of BPC/TB500/GHK-Cu?

My thing is tb/bpc/hgh. I tried throwing in the GHK-Cu for a lil bit and didn't notice any marginal difference ...

 

[Trailmixed]

My thing is tb/bpc/hgh. I tried throwing in the GHK-Cu for a lil bit and didn't notice any marginal difference ...

Ah gotcha, so the tb/bpc was a good combo?

 

[mok4315]

I told yall GI Jane badass!!
Have tou tried tb500 (tb4)?? Sure you have.....

No. Honestly I’m trying to decrease my peptide use. I read up some studies on tb and they were pretty meh. Low dose Tirz is actually mindfuckingly amazing for my chronic injuries. Probably has something to do with the inflammation decrease it leads to. I went off Tirz when I switched to Reta to do my lean bulk, and it was fine at first. About a month later, my SI joints started flaring like I was jamming a knife into them. Also gained like no shit 10lbs of water weight in one week. Went back on 2mg tirz and all that shit reversed in 2 days.

 

[Sampei]

Have any of y'all tried the mix of BPC/TB500/GHK-Cu?

I do it daily 6 weeks on 2 off 1/1/2 mg wise

 

[Trailmixed]

I do it daily 6 weeks on 2 off 1/1/2 mg wise

How's that regimen been? Notice any differences? And if so what?

 

[Sampei]

No. Honestly I’m trying to decrease my peptide use. I read up some studies on tb and they were pretty meh. Low dose Tirz is actually mindfuckingly amazing for my chronic injuries. Probably has something to do with the inflammation decrease it leads to. I went off Tirz when I switched to Reta to do my lean bulk, and it was fine at first. About a month later, my SI joints started flaring like I was jamming a knife into them. Also gained like no shit 10lbs of water weight in one week. Went back on 2mg tirz and all that shit reversed in 2 days.

Yeah many ppl reports consistent decrease of systemic inflammation on Tirzepatide. Not much on reta tho.

Maybe it's the GIP part of tirz

 

[Sampei]

How's that regimen been? Notice any differences? And if so what?

Small injuries gone. I easily feel pain when lifting heavy on chest exercise, my shoulders and elbows. On this regimen I feel nothing but when I stop it comes back quite quickly if I'm not careful on how I lift. So take it with a grain of salt.