mok4315
Member
They sure are and to each their own. But I prefer to go with the figure look. The extra weight helps too, in general self defense situations when you gotta open a can of whoop ass on some dude.
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MESO-Rx
Anabolic Steroids
Qingdao Sigma Chemical Co., Ltd (International, US, EU, Canada and Australia domestic
- Thread starter Qingdao Sigma Chemicals
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Ateam2023
Member
i was considering doing a low dose of Tirz just for the enhanced anti immflamatory benefits as well, did you start straight away at 2 mg of tirz, or lower titrating up?
Proud_papa_pump
Member
We are lucky they allow tablets in prison. Otherwise, no updates at all…
mok4315
Member
I started at 2.5mg. One thing that’s been reported frequently in studies (and that I’ve seen with my brother), is that men respond better to higher doses. So I wouldn’t start lower if I were you.
Ateam2023
Member
the fake boobs just doesn't look good to me, for some reason they're all just overdone and it looks funny, just my obsevation, but they are STILL hot,,
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A third of those people actually had 25% weight loss. Add that to Sema patent up for grabs soon and Sema may become to goto GLP, Norvo stocks be damned!"Failed" from a business perspective.
Both of these trials were intended to give Novo a product to compete with Eli Lilly. Neither did.
CagriSema failed to reach its target and underperformed Reta results,
Novo Nordisk stock crashes after CagriSema misses phase 3 weight-loss goal
A phase 3 trial of Novo Nordisk’s next-generation obesity prospect CagriSema has failed to achieve the level of weight loss targeted by executives, prompting investors to wipe 19% off the | A phase 3 trial of Novo Nordisk’s next-generation obesity prospect CagriSema has failed to achieve the...www.fiercebiotech.com
While it's good to know much higher doses of Sema are safe, triple the dose for a 2.5% median greater weight loss vs 2.4mg, along with a disproportionate increase in sides is nothing to get excited about. What doctor would prescribe this over Tirz?
All they can do with these is drop the price, and say "May not be as good as Zepbound/Reta but it's a better value.", if they do market either.
Ateam2023
Member
i'm not looking to actually drop weight, from your experience is there a realistic way to do tirz for the anti inflammatory benefits or is the weight loss part of the package? I've got so much different information about the different glp1 but tirz definitely has my attention, thanks @mok4315
Letits now
Member
So me being a dick publicly and privately is why I don’t get free shit.
Maybe I should change.
Lowest dosage on trials is 2.5 for tirz.
Ghoul
Member
If I was running Novo, I'd offer a deal to the largest insurers, and offer them a cut price (but undoubtedly still massively profitable) IF they require "Step therapy" like is common practice before covering other expensive drugs.
In other words, "We won't cover other, pricier GLPs, until you try Sema for 12 months first. Only if that fails to lower your BMI below the obesity range will we cover the more expensive option.".
Then Sema becomes the default GLP overnight. If you want a "better" GLP either pay for it yourself (or more likely Eli will have to drop their price to Sema to regain market share).
Because as things stand, why would anyone ask for, or be initially prescribed Wegovy over Zepbound at this point, unless the patient or doctor is completely ignorant as to the superiority of Tirz.
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mok4315
Member
Yeah, 2.5mg is for sure a good place to start. I’m not dropping any weight on 2mg right now and unless you’re a unicorn, I don’t think you will either. You can always adjust and play around with dosages, but 2.5 is pretty safe.
Swolemates365
Member
Dude they ain’t coming back!
Ghoul
Member
The TLDR is that we know Vagal nerve activation moderates systemic inflammation. GLP and GIP both active it. The other effect of Vagal stimulation is a lowering of heart rate variability, which is probobly the cause of increased heart rate in some, particularly, Tirz users. This seems to happen even in the absence of appetite suppression.
Research hasn't gotten far enough to conclusively demonstrate a non-appetite suppression dose can reduce inflammation, but that effect is separate from weight loss, making it entirely possible, in my opinion, that there are benefits to be had at doses that don't induce weight loss.
My guess is the higher the dose you can take without unwanted appetite suppression, the better the odds of inflammation reduction. Some "unlucky" guys find 2.5mg crushes appetite, while others feel nothing below 10mg.
Have you gotten your fasted insulin checked?
mikeh1998
Member
Well, if Bryan Johnson stopped taking it...
TheScholarOfBrew
Banned
Anyone know of the best current peptide supplier until qsc comes back? Want to buy a years supply of sema or reta at least to run. Preferred one who isn't upcharging out the ass ATM. OK with waiting a month.
Vendors shouldn't be upcharging peptides atm; CBP shouldn't be seizing them if its packaged correctly, as far as I understand. SSA looked good to me, but you'd have to check their reviews. Also, some people have said there's issues with reta quality from many sources, so beware.
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No if it’s a panel I’ll throw it on my next labs in a couple weeks.
It is. I'd be interested if you are just super insulin sensitive or if you have hyperinsulinemia.
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