Qingdao Sigma Chemical Co., Ltd (International, US, EU, Canada and Australia domestic

[TheScholarOfBrew]

Are you referring to Sema, Tirz, and Reta?

Yes

 

[Proud_papa_pump]

Anyone got a article or a resource to read up on the differences between these 3. This is a whole new ball game need to learn fast. we s a good write up from a participant in the Reta trial.

Anyone got a article or a resource to read up on the differences between these 3. This is a whole new ball game need to learn fast.

https://www.reddit.com/r/Retatrutide/s/tz0b7FjOle

From a participant in a Reta trial.

 

[rxzed]

Yes

There's lots of studies on Tirz vs Sema, but not Reta. @Ghoul has many posts about GLPs and google scholar is your friend.

A quick rundown though. Sema is a GLP-1 agonist, Tirz is a GLP-1 and GIP agonist. Reta is a GLP-1, GIP, and Glucagon agonist. You can think of them as 1st, 2nd, and 3rd generation drugs. Reta is not fda approved as of now, so data is pretty limited, but Eli Lilly is set to release their findings later this year where it will most likely receive FDA approval. With the evidence available, Tirz is superior in nearly every way; the caveat being that Reta appears better for fat loss. For health benifits, as of now, I would use Tirz. If you want fat loss primarily, Reta is an option. Semaglutide is the most cost efficient, and will still give great results. There's a lot more nuance, but that's the general gist.

 

[Dirthand]

They sure are and to each their own. But I prefer to go with the figure look. The extra weight helps too, in general self defense situations when you gotta open a can of whoop ass on some dude.

I keep trying to tell you guys
MoK= mother fucking GI Jane

 

[Dirthand]

So me being a dick publicly and privately is why I don’t get free shit.
Maybe I should change.

I have no idea really... just be you!!! All a person can be.... really is themselves..
Sending hugs
Peace
D

 

[Ghoul]

I have no idea really... just be you!!! All a person can be.... really is themselves..
Sending hugs
Peace
D

BTW wasn't ignoring your request, but I see you got a wide range of opinions and don't need mine.

I'll only add that no appetite suppression with Sema seems fairly rare, even as low as .50mg most seem to feel it, while tirz/reta gives you a lot more leeway, with few people feeling any appetite suppression in the first few dose steps. Also if Tirz works for you, it is much more economical for the long run, and you can always step up to Reta from Tirz.

 

[Swolemates365]

BTW wasn't ignoring your request, but I see you got a wide range of opinions and don't need mine.

I'll only add that no appetite suppression with Sema seems fairly rare, even as low as .50mg most seem to feel it, while tirz/reta gives you a lot more leeway, with few people feeling any appetite suppression in the first few dose steps. Also if Tirz works for you, it is much more economical for the long run, and you can always step up to Reta from Tirz.

I was subscribed ozympic for a bit made it to top dosage and I didn’t get the appetite suppressant either. It was for my diabetes not weight loss. Now triz black market did do it. I wanna run ret on this show prep.

 

[glpfun]

you guys ever noticed that @chmuse showed up around the same time Tracy left? You ever see them in the same room at the same time?

 

[Ghoul]

I was subscribed ozympic for a bit made it to top dosage and I didn’t get the appetite suppressant either. It was for my diabetes not weight loss. Now triz black market did do it. I wanna run ret on this show prep.

That's a rarity. But non-responders to Sema are not unknown.

It can be because you have a genetic mutation that causes an abundance of GLP receptors, which results in a kind of insensitivity. The overall sensitivity to appetite suppression of Sema has been theorized to be dependent on the overall proportion of receptors agonized.

Women, for instance, in general have a lower density of GLP receptors than men. At the same BMI, they generally respond better to a lower dose.

There's a $300 genetic test that can predict this, along with other factors related to likely success with GLPs,

Sounds like GIP did the trick.

The other possibility is the presence of anti-Sema antibodies. Something seen with users of earlier incretin drugs. Ever injected anything else for diabetes?

 

[Swolemates365]

That's a rarity. But non-responders to Sema are not unknown.

It can be because you have a genetic mutation that causes an abundance of GLP receptors, which results in a kind of insensitivity. The overall sensitivity to appetite suppression of Sema has been theorized to be dependent on the overall proportion of receptors agonized.

Women, for instance, in general have a lower density of GLP receptors than. men, and generally respond better to a lower dose.

There's a $300 genetic test that can predict this, along with other factors related to likely success with GLPs,

Sounds like GIP did the trick.

The other possibility is the natural presence of anti-Sema antibodies. Something seen with users of earlier incretin drugs. Ever injected anything else for diabetes?

Oddly enough I’m not a great responder to any meds. Test, tren, Clen, loratab, addys, really any meds. And alcohol metabolizes quickly in me.

I run about 30iu lantus a day. And metformin at night. I keep fast acting insulin On hand if needed

 

[chmuse]

you guys ever noticed that @chmuse showed up around the same time Tracy left? You ever see them in the same room at the same time?

Did you tag me so I'll compliment your abs again?

 

[Ghoul]

Oddly enough I’m not a great responder to any meds. Test, tren, Clen, loratab, addys, really any meds. And alcohol metabolizes quickly in me.

I run about 30iu lantus a day. And metformin at night. I keep fast acting insulin On hand if needed

Diabetes is known to speed up clearance of drugs metabolized by these enzymes:

CYP1A2, CYP2C9, CYP2C19 and CYP2D6.14

So you can look up a drug "Which enzyme metabolizes xx" and predict whether you'll respond well or require a higher dose for the desired effect.

Something you can bring to your docs attention when they prescribe something new, so they can take that into consideration.

 

[glpfun]

Did you tag me so I'll compliment your abs again?

 

[chmuse]

Diabetes is known to speed up clearance of drugs metabolized by these enzymes:

CYP1A2, CYP2C9, CYP2C19 and CYP2D6.14

So you can look up a drug "Which enzyme metabolizes xx" and predict whether you'll respond well or require a higher dose for the desired effect.

Something you can bring to your docs attention when they prescribe something new, so they can take that into consideration.

If you can get your raw genetic data, there are lots of places you can just plug it in and they'll analyze it for you quite extensively. I have a few genetic mutations that make meds work in really fucky ways. Just make sure the place you choose to get your raw data and then the place that analyzes don't have that they own your genetic information in the fine print, a lot of them will sell it.

 

[Swolemates365]

@chmuse @Ghoul Damn, thank yall for the insight!! Sincerely appreciate it!

 

[Dirthand]

BTW wasn't ignoring your request, but I see you got a wide range of opinions and don't need mine.

I'll only add that no appetite suppression with Sema seems fairly rare, even as low as .50mg most seem to feel it, while tirz/reta gives you a lot more leeway, with few people feeling any appetite suppression in the first few dose steps. Also if Tirz works for you, it is much more economical for the long run, and you can always step up to Reta from Tirz.

I got ya dawg...yeah i got more than i bargained for!!! I really like the idea of what one persons (mok) small amount tirz with the reta.. but I always tend to.go a lil.overboard on things.. I was thinking 3t/5r. I mean im.not trying to lose weight, just built.muscle.lose.a.lol.fat and get some of these health benefits for.these amazing drugs... I had to drop the tirzepatide for surgery (surgeons order) mainly because of the delayed digestion and they want you empty.. I haven't started back..... well.because you want things FREELY Flowing after abdominal surgery I promise...
I think.i may start back next week or week after.(on the glp) maybe long walks starting next week.. no lifting for at least 3-4 more weeks....
Peace

 

[Scout23358]

That’s pre diabetic level.

Yeah. I feel like TIRZ may have saved my bacon, emphasis on may…
I’m an old fart (late 50s) and i did the usual shit, for which I honestly don’t have too many regrets: ate too much, drank way too much and didn’t stay in shape as well as i should. I never went full blown lard-ass, but i got close. Big wake up calls over the past few years and again, if im lucky, the big guy upstairs and modern medicine and some later in life diet and exercise might get me a few more good years or decades.
I am inspired daily by you fucktards and your great physiques and attention to health. Well done boys.

 

[Proud_papa_pump]

I got ya dawg...yeah i got more than i bargained for!!! I really like the idea of what one persons (mok) small amount tirz with the reta.. but I always tend to.go a lil.overboard on things.. I was thinking 3t/5r. I mean im.not trying to lose weight, just built.muscle.lose.a.lol.fat and get some of these health benefits for.these amazing drugs... I had to drop the tirzepatide for surgery (surgeons order) mainly because of the delayed digestion and they want you empty.. I haven't started back..... well.because you want things FREELY Flowing after abdominal surgery I promise...
I think.i may start back next week or week after.(on the glp) maybe long walks starting next week.. no lifting for at least 3-4 more weeks....
Peace

I’ve done Tirz for about 2 years, and Reta for 6 months. Both were extremely effective. I’m choosing to stick with just Reta, due to my outstanding lipids. Even my Apo(B) was at 58, which is awesome for me. Total cholesterol at 123, and Triglycerides at 37. I’m feeling great with those numbers.

 

[chmuse]

View attachment 317681

Are you trying to get me banned?


For the record I priced out gyms yesterday.

 

[Ghoul]

I’ve done Tirz for about 2 years, and Reta for 6 months. Both were extremely effective. I’m choosing to stick with just Reta, due to my outstanding lipids. Even my Apo(B) was at 58, which is awesome for me. Total cholesterol at 123, and Triglycerides at 37. I’m feeling great with those numbers.

Going to be a crowded planet with all these extended lifespans...lol