Qingdao Sigma Chemical Co., Ltd (International, US, EU, Canada and Australia domestic

[Ghoul]

Dude 15 is like max dosing

The guidance from Eli Lily has patients start at 2.5mg, and titrate up another 2.5mg, every four weeks (four pens per box, so it’s always four weeks) or until side effects are tolerated, OR until reach goal weight is reached, and stop the dose at that point, or drop back one level, and stay at maintenance indefinitely, like insulin. It’s not intended to stop taking it after weight loss is finished.

I had been good at 7.5mg, and just wanted the max dose so I’d get extra and “share” with someone (you can remove the internal cart from the pen, and split the dose).

By very slowly titrating up, I didn’t crush appetite, and HS-CRP, lipids, BP, and AIC improved with every increase, until 15mg was tolerable, until eventually it felt like nothing.

In the extended trials, almost everyone regardless of starting weight or total weight loss reached a maintainance dose of 15mg, by slowly titrating, with a few who couldn’t go passed 10mg.

“In SURMOUNT‑4, 92.7% of participants achieved a 15 mg maintenance dose; 7.3% remained at 10 mg ”

The current trial is Surmount MMO, 15,000 people using Sema, Tirz, or Reta for 5 years (going on long after weight loss stops, usually 1 year), to measure the direct cardiovascular protection for non-diabetics, non-weight loss users.

https://joe.bioscientifica.com/downloadpdf/view/journals/joe/263/1/JOE-24-0046.pdf?

 

[nullandvoid]

I'm at 15mg a week and 8% body fat. Sure that's with an InBody, but the scans have been consistently under 9% for a while now. Maybe closer to 10% with error, because the lower you get, the more inaccurate the impedance scanners become. However, I don't think that qualifies as a fat ass. I feel good. It doesn't create any gastro issues, and it's perfectly sustainable. By the time the next dose rolls around, I've still got good suppression, but I can tell it's wearing slightly off due to a tendency to dip into some extra cashews. People want to hate this shit because it flies in the face of convention. It's supposed to be hard. It's supposed to require ironclad willpower, or it doesn't count. However, that same logic can apply to AAS. We should all be natural, or it doesn't count. It's just another tool, and it's a damned good one.

 

[pistonpump]

Judging by the responses I got I think this is the real Tracy. If u have better sources than good for you but buying a kit for 60 compared to 150 from someone who I got all legit gear from in the past is a chance I'll take. Sucks that people are owed from the last shutdown. But man qsc was the balls with price and quality and the large collection of compounds available.

 

[BigNate78]

The guidance from Eli Lily has patients start at 2.5mg, and titrate up another 2.5mg, every four weeks (four pens per box, so it’s always four weeks) or until side effects are tolerated, OR until reach goal weight is reached, and stop the dose at that point, or drop back one level, and stay at maintenance indefinitely, like insulin. It’s not intended to stop taking it after weight loss is finished.

I had been good at 7.5mg, and just wanted the max dose so I’d get extra and “share” with someone (you can remove the internal cart from the pen, and split the dose).

By very slowly titrating up, I didn’t crush appetite, and HS-CRP, lipids, BP, and AIC improved with every increase, until 15mg was tolerable, until eventually it felt like nothing.

In the extended trials, almost everyone regardless of starting weight or total weight loss reached a maintainance dose of 15mg, by slowly titrating, with a few who couldn’t go passed 10mg.

“In SURMOUNT‑4, 92.7% of participants achieved a 15 mg maintenance dose; 7.3% remained at 10 mg ”

The current trial is Surmount MMO, 15,000 people using Sema, Tirz, or Reta for 5 years (going on long after weight loss stops, usually 1 year), to measure the direct cardiovascular protection for non-diabetics, non-weight loss users.

View attachment 361416

https://joe.bioscientifica.com/downloadpdf/view/journals/joe/263/1/JOE-24-0046.pdf?

Love how people try to use the suggestee dosing and even jump peoples shit for using low dose. Its only recommendations as they cant go based off of everyone as every person is different or lazy expecting the drug to do all the work for them while continuing to be trash eaters non exercising. If youve got to get into MAX dosing then theres issues that need to be addressed prior too. Its like dumbasses that stack tirz and reta or one of the 3. I dont think in any way max dosing is healthy one bit

 

[Ghoul]

Love how people try to use the suggestee dosing and even jump peoples shit for using low dose. Its only recommendations as they cant go based off of everyone as every person is different or lazy expecting the drug to do all the work for them while continuing to be trash eaters non exercising. If youve got to get into MAX dosing then theres issues that need to be addressed prior too. Its like dumbasses that stack tirz and reta or one of the 3. I dont think in any way max dosing is healthy one bit

Can you elaborate on the issues you think using the max pharma doses cause?

 

[bubba618]

Love how people try to use the suggestee dosing and even jump peoples shit for using low dose. Its only recommendations as they cant go based off of everyone as every person is different or lazy expecting the drug to do all the work for them while continuing to be trash eaters non exercising. If youve got to get into MAX dosing then theres issues that need to be addressed prior too. Its like dumbasses that stack tirz and reta or one of the 3. I dont think in any way max dosing is healthy one bit

You might consider that max dosing refers to maximum tested and confirmed in clinical trials, but that clinical trials evaluating higher dosages are ongoing. In other words, we don't currently know what a maximum dose really looks like, yet.

 

[Ghoul]

You might consider that max dosing refers to maximum tested and confirmed in clinical trials, but that clinical trials evaluating higher dosages are ongoing. In other words, we don't currently know what a maximum dose really looks like, yet.

For Sema, it was 2.4mg for years. Then when Wegovy came out for weight loss, they found a percentage of weight loss non-responders at the max dose of 2.4mg. They had new trials going up to 7.2mg, larger doses worked for the former non-responders, and there were no safety issues, just the usual side effects people have when starting GLPs. Since Tirz max dose was based on Sema’s max GLP-1 receptor agonism, it’s likely there’s plenty of room in Tirz’a dose too, but no one can say for sure because GIP is also involved. Too much may cause some problem.

You *know* there have been some out there who’ve been hoping these drugs would make people’s eyes fall out, develop penile cancer, or some other well deserved “punishment” for “cheating fatties”.

Or just pharmaphobia. The belief there can be no benefit without some equal, or worse harmful effect in return. (Not unreasonable given past experience, but things have changed in the last few decades).

30 years of GLPs, and the only long term negative effect seems to be people living longer than pension funds and social security would like.

 

[SpicyMeatball]

Dude 15 is like max dosing

Hate to be the one to break the news but the guys around here sometimes take things outside of pharma guidelines.

 

[endtropy]

Hate to be the one to break the news but the guys around here sometimes take things outside of pharma guidelines.

What? You don't think my PCP would be on board with a gram of tren weekly?

 

[ackmack78]

Debating on whether I want to order more of their 40iu GH. Only ordered 2 kits and it's a pretty good deal. But want to see some feels reports along with my own too before I commit too hard

 

[BigNate78]

180 for 36iu kit hahahahahahaha again fuck tracy

 

[tweek]

180 for 36iu kit hahahahahahaha again fuck tracy

Oh damn. I think my last purchase from them was 135 a kit

 

[Cimcity]

Debating on whether I want to order more of their 40iu GH. Only ordered 2 kits and it's a pretty good deal. But want to see some feels reports along with my own too before I commit too hard

I got the 36iu kits a few weeks ago before the testing came back at 40iu so it was $300 shipped for 2 kits. And I’ve already placed a couple orders with QSC the last few months (var and cagri) so I know they always ship fast… TA within a week and good communication.

Everything seems legit. Hands get numb on 4iu if I don’t move them like when reading in bed. IGF levels tripled from an abysmal 51 to 159. I never did business with Tracy back in the old days because I wasn’t in the game back then, but I’ve had nothing but really positive experiences so far in these last couple months.

 

[BigNate78]

I got the 36iu kits a few weeks ago before the testing came back at 40iu so it was $300 shipped for 2 kits. And I’ve already placed a couple orders with QSC the last few months (var and cagri) so I know they always ship fast… TA within a week and good communication.

Everything seems legit. Hands get numb on 4iu if I don’t move them like when reading in bed. IGF levels tripled from an abysmal 51 to 159. I never did business with Tracy back in the old days because I wasn’t in the game back then, but I’ve had nothing but really positive experiences so far in these last couple months.

Yet I can go elsewhere and get 36 for cheaper and elsewhere has also tested yet theu dont raise their prices after the fact. Again fuck tracy

 

[Cimcity]

Yet I can go elsewhere and get 36 for cheaper and elsewhere has also tested yet theu dont raise their prices after the fact. Again fuck tracy

Yeah I definitely haven’t seen other vendors do that. Like Primal won’t even sell something until the testing comes back legit.

 

[Ghoul]

I got the 36iu kits a few weeks ago before the testing came back at 40iu so it was $300 shipped for 2 kits. And I’ve already placed a couple orders with QSC the last few months (var and cagri) so I know they always ship fast… TA within a week and good communication.

Everything seems legit. Hands get numb on 4iu if I don’t move them like when reading in bed. IGF levels tripled from an abysmal 51 to 159. I never did business with Tracy back in the old days because I wasn’t in the game back then, but I’ve had nothing but really positive experiences so far in these last couple months.

51??!!

Unless you’re 92 years old, or something else is wrong with you, you may very well have adult growth hormone deficiency and qualify for a rHGH replacement dose prescription.. Seriously, I’d stop the rHGH for now, see an endocrinologist. complain about “lack of vigor”, just feel run down, and would like your hormones checked (and make sure he includes IGF).

 

[Cimcity]

51??!!

Unless you’re 92 years old, or something else is wrong with you, you may very well have adult growth hormone deficiency and qualify for a rHGH replacement dose prescription.. Seriously, I’d stop the rHGH for now, see an endocrinologist. complain about “lack of vigor”, just feel run down, and would like your hormones checked (and make sure he includes IGF).

I’m 36 years old with no known health issues. After your reply I just checked my bloodwork prior to rHGH. 56* was the original number and the number since starting is actually 106 not 159. I was confusing the number with something else. So still not good even on 4iu.

I never even considered I may actually be deficient. Pharma GH script would be awesome either way tho right? Feeling run down and lethargic was the whole reason I started rHGH and test a couple months ago.

 

[Ghoul]

I’m 36 years old with no known health issues. After your reply I just checked my bloodwork prior to rHGH. 56* was the original number and the number since starting is actually 106 not 159. I was confusing the number with something else. So still not good even on 4iu.

I never even considered I may actually be deficient. Pharma GH script would be awesome either way tho right? Feeling run down and lethargic was the whole reason I started rHGH and test a couple months ago.

36 makes that level even worse:

I’m in a rush so going to cheat and let this sum it up. Make sure you stop rHGH asap. You’ll need 4 weeks, 5 is better, to return to baseline so it’s not elevated when they test. I wouldn’t mention you used rHGH. Complain like the symptoms have been increasing for a year or more, and a buddy recommended a hormone workup. (When they order the tests, “suggest” IGF-1 since “Dr Google” suggested that might cause
your symptoms. If they don’t order it, you may want to get it on your own (just IGF-1), tell the doc your buddy pressured you to do it, and give him the results (make sure he can’t see previous ones), otherwise you may be fucking around for months before they finally test it.

Whatever’s going on, even if not AGHD (but it does look likely), you still need to get to the bottom of it, since none of the causes can be ignored.

——

IGF-1 of 56 in a 36-year-old: Clinical Context

1. Typical IGF-1 levels:
• For adults around 36 years old: roughly 100–300 ng/mL (lab-dependent).
• 56 is significantly below normal, suggesting low GH activity.

2. Possible causes of low IGF-1:
• Adult Growth Hormone Deficiency (AGHD) – pituitary not producing enough GH.
• Other hormonal issues – low thyroid (hypothyroidism), low sex hormones, or adrenal problems.
• Chronic illness or malnutrition – liver disease, kidney disease, severe illness..

3. Symptoms often associated with low IGF-1 / GH deficiency:
• Fatigue, low energy
• Decreased muscle mass / strength
• Increased body fat (especially around abdomen)
• Poor exercise tolerance
• Thinning skin, decreased bone density
• Mood changes, low motivation

4. Next steps typically recommended by specialists:
• Confirm the low IGF-1: repeat test to rule out lab error.
• Full pituitary hormone panel: TSH, free T4, cortisol, LH/FSH, testosterone/estradiol as applicable.
• GH stimulation testing: e.g., insulin tolerance test, arginine-GHRH, or glucagon test to confirm AGHD.
• Evaluate for underlying conditions like liver/kidney disease or malnutrition.
• Imaging: MRI of the pituitary if a deficiency is confirmed, to check for structural causes.

5. Treatment considerations:
• If AGHD is confirmed, GH replacement therapy can improve:
• Body composition (more muscle, less fat)
• Bone density
• Energy and quality of life
• Cardiovascular risk markers

Important: GH therapy is prescription-only and carefully monitored with IGF-1 levels to avoid side effects (like swelling, joint pain, insulin resistance).

 

[Cimcity]

36 makes that level even worse:

I’m in a rush so going to cheat and let this sum it up. Make sure you stop rHGH asap. You’ll need 4 weeks, 5 is better, to return to baseline so it’s not elevated when they test. I wouldn’t mention you used rHGH. Complain like the symptoms have been increasing for a year or more, and a buddy recommended a hormone workup. (When they order the test, “suggest” IGF-1 since “Dr Google” suggested that might cause
your symptoms. If they don’t order it, you may want to get it on your own (just IGF-1), tell the doc your buddy pressured you to do it, and give him the results (make sure he can’t see previous ones), otherwise you may be fucking around for months before they finally test it.

——

IGF-1 of 56 in a 36-year-old: Clinical Context

1. Typical IGF-1 levels:
• For adults around 36 years old: roughly 100–300 ng/mL (lab-dependent).
• 56 is significantly below normal, suggesting low GH activity.

2. Possible causes of low IGF-1:
• Adult Growth Hormone Deficiency (AGHD) – pituitary not producing enough GH.
• Other hormonal issues – low thyroid (hypothyroidism), low sex hormones, or adrenal problems.
• Chronic illness or malnutrition – liver disease, kidney disease, severe illness.
• Medications – glucocorticoids, some chemo, or other hormone therapies.

3. Symptoms often associated with low IGF-1 / GH deficiency:
• Fatigue, low energy
• Decreased muscle mass / strength
• Increased body fat (especially around abdomen)
• Poor exercise tolerance
• Thinning skin, decreased bone density
• Mood changes, low motivation

4. Next steps typically recommended by specialists:
• Confirm the low IGF-1: repeat test to rule out lab error.
• Full pituitary hormone panel: TSH, free T4, cortisol, LH/FSH, testosterone/estradiol as applicable.
• GH stimulation testing: e.g., insulin tolerance test, arginine-GHRH, or glucagon test to confirm AGHD.
• Evaluate for underlying conditions like liver/kidney disease or malnutrition.
• Imaging: MRI of the pituitary if a deficiency is confirmed, to check for structural causes.

5. Treatment considerations:
• If AGHD is confirmed, GH replacement therapy can improve:
• Body composition (more muscle, less fat)
• Bone density
• Energy and quality of life
• Cardiovascular risk markers

Important: GH therapy is prescription-only and carefully monitored with IGF-1 levels to avoid side effects (like swelling, joint pain, insulin resistance).

Thanks for the detailed response brother. Much appreciated. I will absolutely look into it.

 

[juicebro]

Hate to be the one to break the news but the guys around here sometimes take things outside of pharma guidelines.

I was on 20mg reta. Tried taking a break and jumped back on 15mg... I don't think the appetite suppression ever comes back. I'm not just using it for the health benefits. I never needed it to drop weight.