Ghoul
Member
Once you test igfbp1 if you get a poor score what kind of actionable things can you do to improve it. Besides the obvious ones that go along with your post, like reduce stress, not fast, eat in a surplus?
You’ve got to go down the list and address anything contributing to high IGFBP-1.
If inflammation is high, HS-CRP, address the infection or whatever’s causing it. If cholesterol is high, that’s often it and a statin can bring systemic inflammation down dramatically. We were talking about this recently, Pitavastatin 4mg can drop HS-CRP by 50%.
If it’s low insulin levels (which can be difficult to establish in a non diabetic) , a GLP will increase peak insulin post meal and “extinguish” a lot of IGFBP-1 production, bringing levels down. It’ll also lower systemic inflammation.
Verify free t3 annd t4 are mid range. Hypo or hyper thyroids boost igfbp1 .
There are esoteric causes but I haven’t dug into them.(adrenal/cortisol). It’s usually food/insulin too low, or inflammation.
Sometimes lowering the rHGH dose can reduce IGFBP-1 more than IGF-1 drops, increasing bioactive IGF-1, or increasing rHGH can raise IGF-1 while IGFBP-1 stays the same, increasing bioactive IGF-1 (but this method of “busting through” high IGFBP-1 is can cause strong side effects.
Make sure all test results are in nmol units, and you can calculate free IGF-1 (approx) this way:
IGF-1 ÷ (1 + 0.25×IGFBP1 + 0.15×IGFBP3) = Free IGF-1
