The bulk of the powder (“cake” or “puck”) isn’t “filler”. If done right the bulk of the cake is a combination of substances used to do one or more of the following: facilitate the freeze drying of the API/drug; stabilize the API/drug from degradation; enhance solubility in injection solution; encourage less reaction during/after injection; provide a visual indicator of low water content/proper freeze drying; etc.
And basically the vast majority of the cake you see there is void (from the freeze drying out removing all the ice that was there and being replaced with vacuum and continuing to be vacuum if properly sealed). Beyond that the vast majority of the solid matrix/mass occupying the same region as the void is the excipients above, very little is the API drug itself.
Same applies to weight…can’t compare the weight. Only way to know is via testing.
Perhaps the only useful visual comparisons of amounts one might be able to do is when comparing vials from the same batch (same solution into the vials, same lyophilizer run) and even then, it’s not very reliable. If you known they are from the same run and the substances inside are intact cakes (not fucked up by handling) that lyophilized correctly (there’s a pdf out there showing visually all the different ways it can fail) and at that point the cake sizes are different…then you know the automated filler(s) were not adjusted properly and you have significant variations of API/drug. Mostly that’s only useful for the producers/sellers to know since everything can be shuffled around before a kit is put together.
Anyway, generally not “fillers”.
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