Repurposed drugs

[Nidus]

Yeah copy. I had my medications about 1.5 hours earlier than normal yesterday and had a stellar sleep. I think timing helps a lot with these medications.

I thought mirabegron was to stop you waking to go for a piss?

Exactly, stops you from going to pee thus helps me massively to sleep through cause i pee like a horse normally, not every 20-30 minutes but just drink a lot and with a SGTL2 in play you will just urinate more frequently in general

 

[bananafeet]

Exactly, stops you from going to pee thus helps me massively to sleep through cause i pee like a horse normally, not every 20-30 minutes but just drink a lot and with a SGTL2 in play you will just urinate more frequently in general

You know that continuously peeing could mean your kidneys are not shutting off because you're not hitting the proper sleep stages. I had that issue before I started CPAP machine.

Might be unrelated....

 

[Nidus]

You know that continuously peeing could mean your kidneys are not shutting off because you're not hitting the proper sleep stages. I had that issue before I started CPAP machine.

Might be unrelated....

Yep good point but they are fine, i just pee a lot and have a small bladder unfortunately. Prostate is also good togo

 

[King_Cnut]

Interesting. I found taking Mirtazapine seems to make my semaglutide less effective. It seems to work for gastroporesis:

https://www.jamda.com/article/S1525-8610(11)00454-3/abstract

Maybe having some on hand in case of a GLP1 overdose is a good idea?

I've only ever been on tirzepatide while on mirtazapine, but it works just fine for me on a low dose of tirzepatide. That's interesting that you've noticed a difference. Is it quite a marked one?

 

[bananafeet]

I've only ever been on tirzepatide while on mirtazapine, but it works just fine for me on a low dose of tirzepatide. That's interesting that you've noticed a difference. Is it quite a marked one?

Yes. Hunger is still there and the stomach doesn't get totally stopped.

But it's still early days. I'll leave a comment when I spend a month at 3mg per week (previous highest dose of sema).

I think it would probably counter the effects of GLP1 more than GIP. But that's just me bro sciencing. Be good if other people give it a whirl.

 

[bananafeet]

Great lecture on PMDD. I find that any video over 6 years old in YouTube is great. The older the better.

Everything turned to shit on YouTube recently.

View: https://youtu.be/-5ras3wcbAc


I know this is female specific, but the neurology carries over.

 

[bananafeet]

View: https://youtu.be/2Nydy3PeRdE


It seems MAOI's can be used to lower blood pressure. I wonder if it has any benefit for bodybuilders who have mood disorders/hypertension AND high blood pressure.

I am looking into these two compounds:
Phenelzine
Tranylcypromine

There are less sexual dysfunction with this class of drugs which is relevant to me because I still get some sexual dysfunction on sertraline. Mirtazapine helps but any dose of sertraline north of 50mg is touch and go.

The atypical antidepressants or antidepressants that have less sexual side effects usually don't work too well in more severe cases of depression.