Reta phase 3 results out

[RockyP]

https://www.fiercebiotech.com/biotech/eli-lillys-obesity-triple-threat-smashes-efficacy-expectations-phase-3-proves-intolerable

I’m waiting for commentary from @Ghoul @Photon and others. They ratcheted these poor bastards up to 12 mg daily. Can’t imagine taking that much. Efficacy was above expectations but so was discontinuation rate (again, 12 mg is nuts).

Lilly has 7 more Reta trials in the works.

 

[Photon]

https://www.fiercebiotech.com/biotech/eli-lillys-obesity-triple-threat-smashes-efficacy-expectations-phase-3-proves-intolerable

I’m waiting for commentary from @Ghoul @Photon and others. They ratcheted these poor bastards up to 12 mg daily. Can’t imagine taking that much. Efficacy was above expectations but so was discontinuation rate (again, 12 mg is nuts).

Lilly has 7 more Reta trials in the works.

I don't have much to comment lol.
I stopped following GLP news after i decided on using reta.

I'm currently taking 1/2 a vial of SSA 50mg now 1x a week.
The dropout rates do seem really high tho, 3x higher vs tirz.

However, 18.2% of patients dropped out of the retatrutide study due to gastrointestinal side effects. In comparison, 6.2% of patients given a 15-milligram dose of tirzepatide dropped out, Risinger said. The discontinuation rates correlated with a higher body mass index, or BMI, at the start of the test and included patients who dropped out after "perceived excessive weight loss."

https://www.investors.com/news/technology/eli-lillys-experimental-obesity-drug-cut-weight-by-23-7/

 

[MentEFresh]

I don't have much to comment lol.
I stopped following GLP news after i decided on using reta.

I'm currently taking 1/2 a vial of SSA 50mg now 1x a week.
The dropout rates do seem really high tho, 3x higher vs tirz.

However, 18.2% of patients dropped out of the retatrutide study due to gastrointestinal side effects. In comparison, 6.2% of patients given a 15-milligram dose of tirzepatide dropped out, Risinger said. The discontinuation rates correlated with a higher body mass index, or BMI, at the start of the test and included patients who dropped out after "perceived excessive weight loss."

https://www.investors.com/news/technology/eli-lillys-experimental-obesity-drug-cut-weight-by-23-7/

Youre saying youre taking 25mg Reta weekly? Bruh...

 

[juicebro]

I don't have much to comment lol.
I stopped following GLP news after i decided on using reta.

I'm currently taking 1/2 a vial of SSA 50mg now 1x a week.
The dropout rates do seem really high tho, 3x higher vs tirz.

However, 18.2% of patients dropped out of the retatrutide study due to gastrointestinal side effects. In comparison, 6.2% of patients given a 15-milligram dose of tirzepatide dropped out, Risinger said. The discontinuation rates correlated with a higher body mass index, or BMI, at the start of the test and included patients who dropped out after "perceived excessive weight loss."

https://www.investors.com/news/technology/eli-lillys-experimental-obesity-drug-cut-weight-by-23-7/

and there goes my throne as the highest dose reta user

 

[BP_6]

and there goes my throne as the highest dose reta user

Lol, and I got shit from just 8mg with 5mg triz because I happen to have it on had and added that vs bumping the reta to 10 or even 12mg.

Serious question though, no hate. What would be the point of taking a 25mg/week dose of reta even if you can handle the sides? The highest they went up to in the trials was 12mg and even that was only minimally more effective than the 8mg with the most sides of all the dosages. Plus I am sure that dose was used in the more extreme cases of obesity. What is looking to be accomplished?

 

[naps_for_gains]

I'm also running tirzepatide and retatrutide together (currently at 2 mg/week tirzepatide and 4 mg/week retatrutide) and have been for a while now. It's great because I can adjust the tirzepatide dosage to modulate appetite suppression while titrating retatrutide to drive fat loss. The effects are synergistic.

 

[BP_6]

I'm also running tirzepatide and retatrutide together (currently at 2 mg/week tirzepatide and 4 mg/week retatrutide) and have been for a while now. It's great because I can adjust the tirzepatide dosage to modulate appetite suppression while titrating retatrutide to drive fat loss. The effects are synergistic.

I ran tirz for a long time, decided to try reta. Then with all the tirz I had left instead of going full reta, I decided to drop the tirz dose down and add in the reta at comparable trial doses not to exceed the max of what would be with either compound when combined. In other words I count 2mg of reta as 2.5mg of tirz. I could always stop if I didn't like the results.

Well the results currently are what I am looking for so I am not going to change for the time being unless the results or sides change to something that is unfavorable to me.

 

[juicebro]

Have you found tirz to be a lot more effective as far as appetite goes? Reta no longer does anything for me for appetite. I was going to add semaglutide but you're making me consider tirz
@Bp-Sp @naps_for_gains

 

[Photon]

Have you found tirz to be a lot more effective as far as appetite goes? Reta no longer does anything for me for appetite. I was going to add semaglutide but you're making me consider tirz
@Bp-Sp @naps_for_gains

Just increase the reta dose lol

 

[BP_6]

Have you found tirz to be a lot more effective as far as appetite goes? Reta no longer does anything for me for appetite. I was going to add semaglutide but you're making me consider tirz
@Bp-Sp @naps_for_gains

What is your current dosage of reta?

 

[juicebro]

Just increase the reta dose lol

What is your current dosage of reta?

I was on 20mg reta. Backed down to 15mg. It stopped lowering my appetite a while ago no matter the dosage. Been on it over a year now.