MESO-Rx
Anabolic Steroids
Reta phase 3 results out
- Thread starter RockyP
- Start date
Photon
Member
I don't have much to comment lol.
I stopped following GLP news after i decided on using reta.
I'm currently taking 1/2 a vial of SSA 50mg now 1x a week.
The dropout rates do seem really high tho, 3x higher vs tirz.
However, 18.2% of patients dropped out of the retatrutide study due to gastrointestinal side effects. In comparison, 6.2% of patients given a 15-milligram dose of tirzepatide dropped out, Risinger said. The discontinuation rates correlated with a higher body mass index, or BMI, at the start of the test and included patients who dropped out after "perceived excessive weight loss."https://www.investors.com/news/technology/eli-lillys-experimental-obesity-drug-cut-weight-by-23-7/MentEFresh
New Member
Youre saying youre taking 25mg Reta weekly? Bruh...
and there goes my throne as the highest dose reta user
BP_6
Member
Lol, and I got shit from just 8mg with 5mg triz because I happen to have it on had and added that vs bumping the reta to 10 or even 12mg.
Serious question though, no hate. What would be the point of taking a 25mg/week dose of reta even if you can handle the sides? The highest they went up to in the trials was 12mg and even that was only minimally more effective than the 8mg with the most sides of all the dosages. Plus I am sure that dose was used in the more extreme cases of obesity. What is looking to be accomplished?
naps_for_gains
New Member
I'm also running tirzepatide and retatrutide together (currently at 2 mg/week tirzepatide and 4 mg/week retatrutide) and have been for a while now. It's great because I can adjust the tirzepatide dosage to modulate appetite suppression while titrating retatrutide to drive fat loss. The effects are synergistic.
BP_6
Member
I ran tirz for a long time, decided to try reta. Then with all the tirz I had left instead of going full reta, I decided to drop the tirz dose down and add in the reta at comparable trial doses not to exceed the max of what would be with either compound when combined. In other words I count 2mg of reta as 2.5mg of tirz. I could always stop if I didn't like the results.
Well the results currently are what I am looking for so I am not going to change for the time being unless the results or sides change to something that is unfavorable to me.
I was on 20mg reta. Backed down to 15mg. It stopped lowering my appetite a while ago no matter the dosage. Been on it over a year now.
BP_6
Member
Well, that's not a low dose lol. I mean, you could add tirz, but with the reta already over the max dosage, i am not sure adding more would help. How much weight have you lost in that time? Are you pretty damn lean and just want to get leaner? I don't know, but I would guess at a certain point as you start to get to certain stages of leanness depending on the person those hunger signals will strengthen. Possibly to the point where the GLP-1 won't be able to fully suppress them even at high doses.
I have heard people though say in the past like you obviously know, that tirz seems to cause better overall appetite suppression for some.
Its so wild how differently everyone handles or reacts to different compounds. Triz made me feel awful and ended up stopping after 3 weeks. Reta has been solid. Have to force myself to hit my macros and I certainly have no desire to have more than one if any alcoholic drink if I'm in a social setting.
nixu
New Member
Correct me if I’m wrong, but if cagrilintide is available and has shown positive results, why combine two GLP-1s that compete on the same appetite pathways instead of pairing cagrilintide with a GLP-1?
Combinations like retatrutide + tirzepatide will have receptor overlap and biased signaling that can compete or partially cancel each other out. Rather than crowding the same pathway, it seems more logical to use a different one, e.g adding cagrilintide to reta or tirz.
Instead taking already crowded highway, just take the arterial road bro.
Combinations like retatrutide + tirzepatide will have receptor overlap and biased signaling that can compete or partially cancel each other out. Rather than crowding the same pathway, it seems more logical to use a different one, e.g adding cagrilintide to reta or tirz.
Instead taking already crowded highway, just take the arterial road bro.
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Cagri scares me due to the possible Alzheimer's link. Plus I tried it one time and it had me so damn fatigued I could barely function
