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MESO-Rx
Anabolic Steroids
Scam [Complete & Total] Bullshit Alert
- Thread starter Michael Scally MD
- Start date
virtuosa150
New Member
Go on the posted link and click 'find a practioner'.
Scroll down to Pennsylvania.
Yup
Scroll down to Pennsylvania.
Yup
hardasnails1973
New Member
Yup and clients are improving. when the traditional routes were not successful..Don't blame me, medical professionals who are having complex cases are referring them ...
There are 1000's of articles referencing polymorphism...
Bull shit means may simply mean traditional medicine is several years behind the times..
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virtuosa150
New Member
I'm not questioning polymorphism since I know nothing about this. What puts doubt in my mind is some of the snake oil salemen that peedle it.
And, somehow you are in the know!!!!
You have become a very bad joke. For all of the years you have been on this forum you have yet to post ONE example of you how you come to a diagnosis and your so-called treatments. You are a predator on the uninformed, innocent, and desperate.
Caveat Emptor.
Attachments
Oh polymorphisms exist but that doesn't give ANY validity to this concept. Maybe some day real efficacious treatment will be completely tailored to your genetics but that time isn't now.
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hardasnails1973
New Member
The time is now just medical community is not ready...
I have been spoken to psychiatrists about how to use genetic testing to better able to prescribe certain meds for their patients minimizing side effects. More medical professionals are starting to get out from under Big Pharma thumb thinking for themselves. You can use genetic testing to help big pharma to better find drugs suited for certain individuals.
Dr Ben Lynch, myself and others spend several hours a week combing through pubmed and other medical journals for valid information. The approach is researched based.
In the end, its a win win situation for both sides.
IT is a win-LOSE. You make some money as a con/scam artist. You are so FOS to make one ...
[ame]https://www.youtube.com/watch?v=me21QEpg760[/ame]
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hardasnails1973
New Member
Amazing how they thought HRT was bull shit 20-30 years ago now every one is jumping on the band wagon TRT and antiaging clinics are popping up all over the place...go figure LOL
In many cases, TRT is bullshit... or at least unnecessary. In many ways, these antiaging clinics are similar to alternative medicine clinics and holistic medicine clinics. And certainly no better. They exist to cosset the worried well. They run lots of expensive tests and examinations. They have patients answer all kinds of questions and fill out all kinds of questionaires. And in the end, everybody gets the same treatment anyway. When these anxious but healthy patients do get "better," it's not because of the treatment but because of the process. It helps them forget their problems. At least for a while. But by that time, they're usually onto the next disease du jour.
As the old saying goes: The art of medicine is in amusing a patient while nature affects the cure. It's as true today as when Voltaire said it. And that little maxim has sold a lot of Prozac and Valium over the years. It's also kept a lot of snake oil salesmen in business.
Note: Before someone accuses me of saying all TRT is unnecessary, and you know someone will, that's not what I'm saying at all.
CBS why are you suggesting TRT is unnecessary for all comers, lo!
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What kind of BS are you going to use now to perpetuate your scam? https://thinksteroids.com/community/posts/938220
Perhaps you should DEFINE research based Hans!
If I recall correctly were you not going to "publish your findings" from well over ten years of practicing and propagating this ruse.
If I recall correctly were you not going to "publish your findings" from well over ten years of practicing and propagating this ruse.
cvictorg
New Member
Homocysteine and MTHFR Mutations
Some people develop an elevated homocysteine level in part because of a genetic predisposition. The MTHFR gene mentioned previously produces an enzyme that helps regulate homocysteine levels in the body. If there is a genetic error (called a mutation) in the MTHFR gene, homocysteine levels may not be regulated properly. Genetic mutations in MTHFR are the most commonly known inherited risk factor for elevated homocysteine levels. We all have 2 MTHFR genes, one inherited from each parent. Some people have a genetic mutation in one or both of their MTHFR genes. People with mutations in one MTHFR gene are called “heterozygous” for the MTHFR mutation; if mutations are present in both genes, the person is said to be “homozygous” for the mutation.
The most common MTHFR mutation is called the MTHFR C677T mutation, or the “thermolabile” MTHFR mutation. Another common mutation is called MTHFR A1298C. To have any detrimental effect, mutations must be present in both copies of a person’s MTHFR genes. Having only one mutation, ie, being heterozygous, is, from a medical perspective, irrelevant. Even when 2 MTHFR mutations are present (eg, 2 C677T mutations, or one C677T mutation and one A1298C mutation), not all people will develop high homocysteine levels. Although these mutations do impair the regulation of homocysteine, adequate folate levels essentially “cancel out” this defect.
Understanding Genetics
The C677T variant is a change in the instruction manual that makes the MTHFR protein less able to deal with heat. The C677T version of the MTHFR protein is like a microwave with a glitch that causes it to sometimes spark and short-circuit if the weather gets too hot.
So, someone with the C677T variant has a MTHFR protein that doesn't work all of the time because of the glitch. And so, they have a microwave that can't always do its important job of melting butter.
But as I said before, we have two copies of each set of instructions – one from mom, and one from dad. So fortunately, most people with this version of the MTHFR gene have another MTHFR gene, or set of microwave instructions, that is just fine. The other working microwave can take over to melt the solid butter when the C677T microwave can't.
But problems can happen if both instruction manuals have the change. For example, a person with two faulty microwaves will be less able to make the important recipes with melted butter in them. Having too much solid butter lying around can also cause problems.
So, this is why having two C677T versions of the MTHFR gene can increase the chance of symptoms, like heart disease, that we mentioned before. But remember – not everyone with two C677T variants has symptoms. Some people manage just fine not being able to melt butter or having too much extra butter lying around.
And in fact, a person can deal with many of the symptoms of having two C677T variants by taking extra B vitamins. In a way, this is like using pre-melted butter, or maybe vegetable oil, to make the recipes needing melted butter. B vitamins can help the C677T version of the MTHFR protein do its job.
The second variant we mentioned, A1298C, has been studied a little bit less. It can cause problems too, although it seems that it only does when it comes along with the C677T variant. If one of the person's instruction manuals has the C677T variant, and the person's other manual has the A1298T variant, there isn't a fully working microwave to take over.
http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/81648
Hyperhomocysteinemia is an independent risk factor for coronary artery disease, acute myocardial infarction, peripheral arterial disease, stroke, and venous thromboembolism. Homocysteine is a sulfhydryl-containing amino acid formed as an intermediary during the conversion of methionine to cystathionine. Genetic or nutrition-related disturbances (eg, deficiency of vitamins B12, B6, and folic acid) may impair the transsulfuration or remethylation pathways of homocysteine metabolism and cause hyperhomocysteinemia. The enzyme MTHFR catalyzes reduction of 5,10-methylene tetrahydrofolate to 5-methyl tetrahydrofolate, the major form of folate in plasma; 5-methyl tetrahydrofolate serves as a methyl donor for remethylation of homocysteine to methionine. Patients with severe MTHFR deficiency (enzymatic activity 0%-20% of normal) develop homocysteinuria, a severe disorder with a wide range of associated clinical manifestations, including developmental delay, mental retardation, and premature vascular disease. Seven unique MTHFR mutations have been associated with homocysteinuria, all among patients who were either homozygous or compound heterozygotes for 1 or more of these mutations.
A milder deficiency of MTHFR, with approximately 50% residual enzyme activity and marked enzyme lability to heat inactivation, is associated with a cytosine to thymine mutation at nucleotide position 677 (C677->T), encoding for an alanine-223 to valine substitution (MTHFR C677T). Patients who are homozygous for the MTHFR C677T mutation may develop hyperhomocysteinemia, especially with concurrent deficiency of vitamins B12, B6 (pyridoxine), or folic acid. This mutation is quite common, with a carrier frequency of 31% to 39% (homozygote frequency 9%-17%) among the white North American population. The MTHFR C677T mutation test is a direct assay of patient leukocyte genomic DNA.
Functional Wisdom...healthy updates from Dr. Jill!: MTHFR gene mutation... What's the big deal about Methylation?
MMS: Error
Holy MTHFR! | Easy To Love But Hard to Raise
Some people develop an elevated homocysteine level in part because of a genetic predisposition. The MTHFR gene mentioned previously produces an enzyme that helps regulate homocysteine levels in the body. If there is a genetic error (called a mutation) in the MTHFR gene, homocysteine levels may not be regulated properly. Genetic mutations in MTHFR are the most commonly known inherited risk factor for elevated homocysteine levels. We all have 2 MTHFR genes, one inherited from each parent. Some people have a genetic mutation in one or both of their MTHFR genes. People with mutations in one MTHFR gene are called “heterozygous” for the MTHFR mutation; if mutations are present in both genes, the person is said to be “homozygous” for the mutation.
The most common MTHFR mutation is called the MTHFR C677T mutation, or the “thermolabile” MTHFR mutation. Another common mutation is called MTHFR A1298C. To have any detrimental effect, mutations must be present in both copies of a person’s MTHFR genes. Having only one mutation, ie, being heterozygous, is, from a medical perspective, irrelevant. Even when 2 MTHFR mutations are present (eg, 2 C677T mutations, or one C677T mutation and one A1298C mutation), not all people will develop high homocysteine levels. Although these mutations do impair the regulation of homocysteine, adequate folate levels essentially “cancel out” this defect.
Understanding Genetics
The C677T variant is a change in the instruction manual that makes the MTHFR protein less able to deal with heat. The C677T version of the MTHFR protein is like a microwave with a glitch that causes it to sometimes spark and short-circuit if the weather gets too hot.
So, someone with the C677T variant has a MTHFR protein that doesn't work all of the time because of the glitch. And so, they have a microwave that can't always do its important job of melting butter.
But as I said before, we have two copies of each set of instructions – one from mom, and one from dad. So fortunately, most people with this version of the MTHFR gene have another MTHFR gene, or set of microwave instructions, that is just fine. The other working microwave can take over to melt the solid butter when the C677T microwave can't.
But problems can happen if both instruction manuals have the change. For example, a person with two faulty microwaves will be less able to make the important recipes with melted butter in them. Having too much solid butter lying around can also cause problems.
So, this is why having two C677T versions of the MTHFR gene can increase the chance of symptoms, like heart disease, that we mentioned before. But remember – not everyone with two C677T variants has symptoms. Some people manage just fine not being able to melt butter or having too much extra butter lying around.
And in fact, a person can deal with many of the symptoms of having two C677T variants by taking extra B vitamins. In a way, this is like using pre-melted butter, or maybe vegetable oil, to make the recipes needing melted butter. B vitamins can help the C677T version of the MTHFR protein do its job.
The second variant we mentioned, A1298C, has been studied a little bit less. It can cause problems too, although it seems that it only does when it comes along with the C677T variant. If one of the person's instruction manuals has the C677T variant, and the person's other manual has the A1298T variant, there isn't a fully working microwave to take over.
http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/81648
Hyperhomocysteinemia is an independent risk factor for coronary artery disease, acute myocardial infarction, peripheral arterial disease, stroke, and venous thromboembolism. Homocysteine is a sulfhydryl-containing amino acid formed as an intermediary during the conversion of methionine to cystathionine. Genetic or nutrition-related disturbances (eg, deficiency of vitamins B12, B6, and folic acid) may impair the transsulfuration or remethylation pathways of homocysteine metabolism and cause hyperhomocysteinemia. The enzyme MTHFR catalyzes reduction of 5,10-methylene tetrahydrofolate to 5-methyl tetrahydrofolate, the major form of folate in plasma; 5-methyl tetrahydrofolate serves as a methyl donor for remethylation of homocysteine to methionine. Patients with severe MTHFR deficiency (enzymatic activity 0%-20% of normal) develop homocysteinuria, a severe disorder with a wide range of associated clinical manifestations, including developmental delay, mental retardation, and premature vascular disease. Seven unique MTHFR mutations have been associated with homocysteinuria, all among patients who were either homozygous or compound heterozygotes for 1 or more of these mutations.
A milder deficiency of MTHFR, with approximately 50% residual enzyme activity and marked enzyme lability to heat inactivation, is associated with a cytosine to thymine mutation at nucleotide position 677 (C677->T), encoding for an alanine-223 to valine substitution (MTHFR C677T). Patients who are homozygous for the MTHFR C677T mutation may develop hyperhomocysteinemia, especially with concurrent deficiency of vitamins B12, B6 (pyridoxine), or folic acid. This mutation is quite common, with a carrier frequency of 31% to 39% (homozygote frequency 9%-17%) among the white North American population. The MTHFR C677T mutation test is a direct assay of patient leukocyte genomic DNA.
Functional Wisdom...healthy updates from Dr. Jill!: MTHFR gene mutation... What's the big deal about Methylation?
MMS: Error
Holy MTHFR! | Easy To Love But Hard to Raise
23andMe has NOT provided any validation of their testing/methodology and conclusions. NONE!
What's your point?
How does this have anything to do with 23andMe?
By your apparent logic, we could set up a business on DNA testing. All we need to do is tell the FDA to trust us. That is what 23andMe is doing. Did you read the FDA letter? http://www.fda.gov/ICECI/EnforcementActions/WarningLetters/2013/ucm376296.htm
FWIW: Even here we see wackos touting the MTHFR mutation and Autism!!! These wackos desire to make SNP into much much more than what they are. And, make false claims for $$$.
Autism Cures Promised by DNA Testers Belied by Regulators
Autism Cures Promised by DNA Testers Belied by Regulators - Bloomberg
What's your point?
How does this have anything to do with 23andMe?
By your apparent logic, we could set up a business on DNA testing. All we need to do is tell the FDA to trust us. That is what 23andMe is doing. Did you read the FDA letter? http://www.fda.gov/ICECI/EnforcementActions/WarningLetters/2013/ucm376296.htm
FWIW: Even here we see wackos touting the MTHFR mutation and Autism!!! These wackos desire to make SNP into much much more than what they are. And, make false claims for $$$.
Autism Cures Promised by DNA Testers Belied by Regulators
Autism Cures Promised by DNA Testers Belied by Regulators - Bloomberg
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Why do you think 23andMe did NOT provide the requisite studies? IMO, they do NOT have the studies! In other words, for much, maybe ALL, they are one BIG scam. Their mission while noble is not being done nobly.
Body blow: How 23andMe brought down the FDA's wrath
Body blow: How 23andMe brought down the FDA's wrath | The Verge
Body blow: How 23andMe brought down the FDA's wrath
Body blow: How 23andMe brought down the FDA's wrath | The Verge
cvictorg
New Member
http://www.medscape.com/viewarticle/743620
New Evidence Favors the Folate Hypothesis for Autism
http://www.jpands.org/vol9no4/boris.pdf
Association of MTHFR Gene Variants with Autism
New Evidence Favors the Folate Hypothesis for Autism
http://www.jpands.org/vol9no4/boris.pdf
Association of MTHFR Gene Variants with Autism
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