Serostim vs other pharma brands

[Para_33]

In the book, stay tuned.

Estrogens reduce IGF-I bioavailability.

Curious, How come the drug combo of choice in cattle for bulking them Up is trenbolone acetate and estradiol as opposed to just straight Trenbolone ?

 

[Type-IIx]

Curious, How come the drug combo of choice in cattle for bulking them Up is trenbolone acetate and estradiol as opposed to just straight Trenbolone ?

Because estrogens augment IGF-I and do not increase IGFBP-1 in ruminants (unlike man).

 

[Type-IIx]

My biggest issue at the moment is whether to stick with serostim and just deal with the fluid retention and what *seems* to be slightly less benefits, just for the fact that I know that’s it’s 100% real and straight out of a US pharmacy. Vs switching to Genotropin/Norditropin with a higher likelihood of getting fakes at some point.

@Type-IIx whats your opinion on the number pharma grade fakes in the market? Do you think it’s over exaggerated or vice versa & not worth the risk?

Well, Jano has mentioned fake "pharma" rhGH and peptides are among the very most faked products he receives, but he's never published any stats on this (and given legal/privacy constraints, he likely cannot). He has said the following: "roughly estimating, over 90% of pharma gear is fake (as in produced illegally by UGLs), but 'only' about 70% is bunk. The remaining 20% are fake, but properly dosed with the right compound." See if he can comment more, @janoshik

 

[TjSquared]

Well, Jano has mentioned fake "pharma" rhGH and peptides are among the very most faked products he receives, but he's never published any stats on this (and given legal/privacy constraints, he likely cannot). He has said the following: "roughly estimating, over 90% of pharma gear is fake (as in produced illegally by UGLs), but 'only' about 70% is bunk. The remaining 20% are fake, but properly dosed with the right compound." See if he can comment more, @janoshik

90%.. yikes. Paying for pharma grade just to get some cheap generic inside is just as bad as getting straight up bunk stuff IMO

 

[janoshik]

Well, Jano has mentioned fake "pharma" rhGH and peptides are among the very most faked products he receives, but he's never published any stats on this (and given legal/privacy constraints, he likely cannot). He has said the following: "roughly estimating, over 90% of pharma gear is fake (as in produced illegally by UGLs), but 'only' about 70% is bunk. The remaining 20% are fake, but properly dosed with the right compound." See if he can comment more, @janoshik

I don't think I have anything to add. I can't publish stats because I have no proofs and I often am unable to identify the genuiness of the sample, but let's just say there are some indicators, such as the origin.

Only, off the top of my head I believe the bunk number to be much lower at this point.

 

[readalot]

Changes in Manufacturing Processes of Biologic Therapies Can Alter the Immunogenicity Profile of the Product

Manufacturing process changes may alter the characteristics of a protein therapeutic. In 2009, somatropin (version 1.0), a recombinant human growth hormone therapeutic, underwent a manufacturing update (version 1.1). The immunogenicity of somatropin version ...

www.ncbi.nlm.nih.gov

The somatropin AQ version 1.1 process represented a comprehensive redesign of the somatropin drug substance manufacturing process (Tables S1 and S2). Although the Escherichia coli cell line and cell banks were not changed, significant changes were made to the fermentation, harvest, purification, and bulk storage steps.

With fermentation, new automated equipment, media and nutrient feeds, and process parameter set points were used. These changes eliminated animal‐derived raw materials, increased the rHGH titer, and reduced the number of fermentations needed to produce one bulk lot from three to one. During the harvest step, new homogenization equipment in a closed system was used to eliminate open processing steps, which previously exposed the product to the environment. The purification step incorporated new chromatography resin types to allow for fewer chromatography steps. For bulk storage, implementation of a freeze‐thaw option for unformulated bulk provided greater supply‐chain flexibility by allowing long‐term storage prior to final formulation at the manufacturing site.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158213/bin/CPT-107-988-s001.pdf