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Ghoul said:
I hear "I feel nothing on Reta, this is great!", so often, it leaves me shaking my head, lol.
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Honestly, I started wondering if the whole Reta hype was just a push by YouTubers to drive affiliate sales. Personally, I saw no real benefits over Tirz.

I didn't get bloodwork done, so maybe some markers improved, but my blood glucose stayed the same, and hunger suppression only kicked in at 10mg (and it's very mild). Meanwhile, Tirz at 2.5mg had me feeling nauseous.

With Reta, my resting heart rate went up, lethargy got worse, and the only noticeable effect was reduced food noise and a lighter wallet.

Thinking of switching back to Tirz or trying something new. Not changing anything yet since I'm late in prep, but planning to switch during my push phase.

Main goals: Maintaining good insulin sensitivity, stable BG with high carbs, lower inflammation, and better satiety while reversing from a deep deficit. Any suggestions?
 
pewex said:
Honestly, I started wondering if the whole Reta hype was just a push by YouTubers to drive affiliate sales. Personally, I saw no real benefits over Tirz.

I didn't get bloodwork done, so maybe some markers improved, but my blood glucose stayed the same, and hunger suppression only kicked in at 10mg (and it's very mild). Meanwhile, Tirz at 2.5mg had me feeling nauseous.

With Reta, my resting heart rate went up, lethargy got worse, and the only noticeable effect was reduced food noise and a lighter wallet.

Thinking of switching back to Tirz or trying something new. Not changing anything yet since I'm late in prep, but planning to switch during my push phase.

Main goals: Maintaining good insulin sensitivity, stable BG with high carbs, lower inflammation, and better satiety while reversing from a deep deficit. Any suggestions?
Click to expand...

Tirz is incredibly effective. It's likely superior for glucose control. Side effects are mild compared to Sema.

Most of the fatigue people report on Sema and Tirz is probobly the initial calorie deficit, and some other effects the body adapts to, so by the time they switch to Reta those effects are behind them, not because Reta avoids causing them.

Reta is novel in a few ways, including glucagon agonism, which is new without long term data on its
impact, and its very strong GIP agonism. 8x natural GIP binding strength, Tirz has the same binding to GIP as the natural hormone. I've seen some suggestion this may be causing GIP downregulation which explains why it's not clearly better at regulating glucose than Tirz, and who knows what the long term impact will be.

Given how successful Tirz (and Sema) have been proven, including many years of maintainance dose use without loss of effectiveness, for most people, they'd seem like a better option.

Reta's lower appetite suppression may be best for short term use in a cut, not causing too much appetite suppression while providing glucose control.

If someone wants something new. amilyn/tirz combo will be probably be available from UGL soon, showing even faster weight loss but with much better muscle preservation.

I actually wonder if Reta will be canned by Eli in favor of the new amilyn/tirz combo they have in trials.
 
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phenominal34 said:
“With Reta, my resting heart rate went up, lethargy got worse, and the only noticeable effect was reduced food noise and a lighter wallet.”


First I ever heard of lethargy is worse on Reta than Tirz.
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This might not be a completely fair assessment since I started prep using Tirz before switching to Reta, so the lethargy could be from overall fatigue. However, it did begin pretty early on.

I definitely expected more from Reta, especially with all the hype around glucose control, but I haven't noticed any changes even deep in prep (which might be influenced by my use of 18 IU HGH and no insulin).

There are a lot of variables at play currently, but based on my experience and overall well being, I believe Tirz might be a better option for me moving forward. I'll keep experimenting with both compounds since I'm placing an order this group buy. Just trying to decide what to get so I can plan ahead for my rebound :)
 
pewex said:
This might not be a completely fair assessment since I started prep using Tirz before switching to Reta, so the lethargy could be from overall fatigue. However, it did begin pretty early on.

I definitely expected more from Reta, especially with all the hype around glucose control, but I haven't noticed any changes even deep in prep (which might be influenced by my use of 18 IU HGH and no insulin).

There are a lot of variables at play currently, but based on my experience and overall well being, I believe Tirz might be a better option for me moving forward. I'll keep experimenting with both compounds since I'm placing an order this group buy. Just trying to decide what to get so I can plan ahead for my rebound :)
Click to expand...

Eli Lilly may be viewing Reta as "meh", unworthy of being launched as the Zepbound successor after the initial results with their new amilyn/tirz combo.

"We think the data today is a sign that the real successor to tirzepatide is the tirzepatide-eloralintide combo, said Jefferies analyst Akash Tewari."





 
Ghoul said:
Eli Lilly may be viewing Reta as "meh", unworthy of being launched as the Zepbound successor after the initial results with their new amilyn/tirz combo.

"We think the data today is a sign that the real successor to tirzepatide is the tirzepatide-eloralintide combo, said Jefferies analyst Akash Tewari."





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Thanks for the info. I hadn't heard of that compound before, so I'll definitely keep an eye out for Amylin and grab it once it becomes available.

For now, I'll probably just go with a kit of Tirz and Reta.

Not gonna lie, I'm kind of obsessed with insulin sensitivity and BG control. My levels run pretty high when I'm on a solid dose of HGH, so I'm always looking for ways to manage it without abusing insulin (though I still use it on high carb days).

Got any peptide suggestions to stack with Tirz? I'm placing an order this group buy and want to experiment with a few compounds over the next few weeks.
 
pewex said:
Thanks for the info. I hadn't heard of that compound before, so I'll definitely keep an eye out for Amylin and grab it once it becomes available.

For now, I'll probably just go with a kit of Tirz and Reta.

Not gonna lie, I'm kind of obsessed with insulin sensitivity and BG control. My levels run pretty high when I'm on a solid dose of HGH, so I'm always looking for ways to manage it without abusing insulin (though I still use it on high carb days).

Got any peptide suggestions to stack with Tirz? I'm placing an order this group buy and want to experiment with a few compounds over the next few weeks.
Click to expand...

If you're focused on glucose control, a critical part of so many aspects of health, invest in a good continuous glucose monitor like the Freestyle Libre 3 plus.

I'm not exaggerating when I say it'll change your life, in terms of diet and habits.

I wish every biomarker could be monitored in real time and logged like glucose is with this thing.

Size of a penny, completely unobtrusive, and an amazing insight into how your biology is functioning in real time.
 
I received my TR30 from Sigma German warehouse in 8 days. I was lucky to receive the package in my opinion. They omitted vital address information which I supplied to them. Company at the building address? Removed. Locker ID? Removed. Just a street address and name.

Next time when I receive the DHL tracking I will update the address myself to ensure they don't make any fuck ups.
 
xrayphoton13 said:
Yeah. I'd call it inferior for myself. I get no appetite suppression at all. Tirzepatide I'm miserable if I start to eat too much. It works way better *for me*
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The fact that you’ve tried both makes your comment hold more weight than some on here who have not and think Tirz is superior. As far as bodybuilders/weightlifters go, the feedback I’ve read makes me believe Reta is better than Tirz for most. Tirz was great for weight loss, but Reta was much better for making gains in the gym. You can eat as much or as little as you like. The glucose control is “likely” better than what you get from Tirz. And my metabolism was crazy high. I continued to get ripped even when eating excess calories.

Honestly if you haven’t tried both and don’t lift your opinion of Reta means nothing at all.
 
Ghoul said:
If you're focused on glucose control, a critical part of so many aspects of health, invest in a good continuous glucose monitor like the Freestyle Libre 3 plus.

I'm not exaggerating when I say it'll change your life, in terms of diet and habits.

I wish every biomarker could be monitored in real time and logged like glucose is with this thing.

Size of a penny, completely unobtrusive, and an amazing insight into how your biology is functioning in real time.
Click to expand...
I've heard of CGMs but never looked into them much, thought you needed a prescription and that the readings were delayed since they measure glucose IM, not directly in the blood.

Just checked and saw they're around $130/month without a prescription, so I might try it for a month or two. My diet is pretty repetitive, so it could be interesting to see how specific foods affect me and how my blood sugar correlates with how I feel.

How have you been using your CGM? Any surprising insights or changes you've made that actually improved your daily routine or blood glucose management?
 
BamaCrazy said:
The fact that you’ve tried both makes your comment hold more weight than some on here who have not and think Tirz is superior. As far as bodybuilders/weightlifters go, the feedback I’ve read makes me believe Reta is better than Tirz for most. Tirz was great for weight loss, but Reta was much better for making gains in the gym. You can eat as much or as little as you like. The glucose control is “likely” better than what you get from Tirz. And my metabolism was crazy high. I continued to get ripped even when eating excess calories.

Honestly if you haven’t tried both and don’t lift your opinion of Reta means nothing at all.
Click to expand...

Lol, you're such a passive aggressive pussy.
 
With Tirz I could not finish a meal before the nausea kicked in. I do not have that issue with Reta.

However while dieting very hard.... it would be nice to have a LITTLE more appetite suppression.

I dont want to switch to tirz though because I still need to eat alot on refeeds.

So for bodybuilding I still maintain that Reta is superior.
 
Ghoul said:
Lol, you're such a passive aggressive pussy.
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You’re a fucking retard who relies on ChatGPT to give you answers when you’ve never tried something. But always seem to have an opinion on everything. If you don’t know something shut the fuck up you idiot. We get it. You are a fat ass and love Tirz. You don’t lift weights or use steroids so Reta has very little use to you. lol

You are a sad douchebag Ghoul.
 
pewex said:
Just checked and saw they're around $130/month without a prescription, so I might try it for a month or two.
Click to expand...

shop around, you can find them cheaper than that. if you are in the US, even check Amazon. they often have subscriptions discounts that you can cancel at anytime. at least they do / did on the Dexcom Stelo.
 
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